{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T19:43:17Z","timestamp":1794512597795,"version":"4.9.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016071","name":"Goldschmidt Jacobson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hyponatremia, the most common electrolyte disorder in hospitalized patients, has been largely associated with increased risk of osteoporosis. Preclinical studies suggest that hyponatremia stimulates osteoclast activity. This study evaluated whether normalization of hyponatremia impacts osteoclast activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>In this prospective, observational study we included patients with serum sodium &amp;lt;135\u2005mmol\/L hospitalized at the University Hospital of Basel, Switzerland, between 03\/2020 and 02\/2025. Premenopausal status, steroid therapy, hypogonadism, fractures, hyperparathyroidism or anti-osteoporotic treatments were exclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sodium and markers of bone resorption (CTX) and bone formation (P1NP) were measured at baseline and after 10 (\u00b13) days and compared between patients who achieved normonatremia versus those who remained hyponatremic. A multivariable model was implemented to adjust for age, sex, BMI, comorbidities, smoking habits, vitamin D levels and volume status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-one patients (65.8% male, mean age 68.6, standard deviation 16.6 years) completed the study. Median (IQR) sodium at baseline was 130\u2005mmol\/L (127-132), with 60% of patients having mild hyponatremia. Serum-CTX at baseline in patients with persistent hyponatremia at day10 (n = 19, 46.3%) and patients reaching normonatremia (n = 22, 53.7%) were similar (median (IQR) 0.41 (0.29-0.53) vs 0.41 (0.37-0.66) ng\/mL, P = .35), whereas they differed at day 10 (0.54 (0.37-0.58) vs 0.35\u2005ng\/mL (0.26-0.45), P = .02). The multivariable linear model showed an association between normonatremia on day 10 and a decrease in CTX (\u03b2-coefficient \u2212.18, 95% CI \u22120.30 to \u22120.08, P = .002). P1NP showed no differences between patients with persistent and normalized sodium at both baseline and day10 (P &amp;gt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In hospitalized patients with hyponatremia, sodium normalization is associated with attenuated osteoclast activity. Correction of even mild hyponatremia could thus be beneficial for counteracting bone loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf242","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:23:07Z","timestamp":1763644987000},"page":"651-658","source":"Crossref","is-referenced-by-count":6,"title":["Normalization of hyponatremia in hospitalized patients decreases osteoclast activity"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-1483","authenticated-orcid":false,"given":"Laura","family":"Potasso","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel 4031 ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , Basel 4031 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-4685","authenticated-orcid":false,"given":"Julie","family":"Refardt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel 4031 ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , Basel 4031 ,","place":["Switzerland"]},{"name":"Department of Internal Medicine, Erasmus Medical Center , Rotterdam 3015 GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-7889","authenticated-orcid":false,"given":"Sophie","family":"Monnerat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel 4031 ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , Basel 4031 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0619-821X","authenticated-orcid":false,"given":"Christian","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel 4031 ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , Basel 4031 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-0965","authenticated-orcid":false,"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel 4031 ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , Basel 4031 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"7 SUPPL. 1","key":"2025120207012083600_lvaf242-B1","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1016\/j.amjmed.2006.05.005","article-title":"Incidence and prevalence of hyponatremia","volume":"119","author":"Upadhyay","year":"2006","journal-title":"Am J Med"},{"issue":"1","key":"2025120207012083600_lvaf242-B2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/ki.2015.4","article-title":"Current treatment practice and outcomes. 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