{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:24:50Z","timestamp":1792808690349,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovation Fund of the Federal Joint Committee in Germany","award":["01VSF19013"],"award-info":[{"award-number":["01VSF19013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Endocrine and metabolic diseases are known to be common late effects in childhood cancer survivors (CCS). We assessed the prevalence of these diseases in a large German CCS cohort, and a matched comparison population, using health claims data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The cohort study was based on record linkage between the nationwide German Childhood Cancer Registry and claims data from 13 major German statutory health insurances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The monitored insurance period covered the years 2017-2021. We assessed the frequencies of endocrine and metabolic diseases among 11 863 five-year CCS, diagnosed 1991-2021, with continuous insurance coverage and a matched comparison group of 35 589 insured persons without a history of childhood cancer. We present prevalence and prevalence ratios (PR) with corresponding 95% confidence intervals (95% CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At least one endocrine or metabolic disease was recorded in 31.3% of survivors (n = 3716) and in 16.4% of the comparison group (n = 5819, PR = 1.9; 95% CI: 1.8-2.0). The frequency of diseases was higher among females than among males in both groups. The PR was 2.4 (95% CI: 2.3-2.5) for males and 1.6 (95% CI: 1.5-1.7) for females. The frequency of at least one disease increased with increasing attained age. The disease with the highest frequency among CCS was hypothyroidism (15.85%), and the highest PR was estimated for patients with primary thyroid cancer (43.5; 95% CI: 24.2-78.1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study highlights the increased vulnerability of CCS to endocrine and metabolic diseases compared to the general population and underscores the need for risk-adapted surveillance during the whole survivorship trajectory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag010","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:42:51Z","timestamp":1768480971000},"page":"102-113","source":"Crossref","is-referenced-by-count":1,"title":["Endocrine and metabolic late effects in childhood cancer survivors in Germany: the VersKiK study"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-1105","authenticated-orcid":false,"given":"Pietro","family":"Trocchi","sequence":"first","affiliation":[{"name":"Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University , 39120 Magdeburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Swart","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University , 39120 Magdeburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Aleshchenko","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University , 39120 Magdeburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiltrud","family":"Merzenich","sequence":"additional","affiliation":[{"name":"German Childhood Cancer Registry, Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology, and Informatics, University Medical Centre of Johannes Gutenberg University Mainz , 55101 Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Ronckers","sequence":"additional","affiliation":[{"name":"German Childhood Cancer Registry, Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology, and Informatics, University Medical Centre of Johannes Gutenberg University Mainz , 55101 Mainz ,","place":["Germany"]},{"name":"Division of CAYA Cancer Survivorship Research, German Cancer Research Center , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Baust","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Hospital Bonn , 53127 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-7982","authenticated-orcid":false,"given":"Gabriele","family":"Calaminus","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Hospital Bonn , 53127 Bonn ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-2957","authenticated-orcid":false,"given":"Thorsten","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Hospital of Schleswig-Holstein, Campus L\u00fcbeck , 23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ihle","sequence":"additional","affiliation":[{"name":"PMV Research Group at the Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Cologne and University of Cologne, Faculty of Medicine , 50931 Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"K\u00fcpper-Nybelen","sequence":"additional","affiliation":[{"name":"PMV Research Group at the Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Cologne and University of Cologne, Faculty of Medicine , 50931 Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"L\u00fcpkes","sequence":"additional","affiliation":[{"name":"OFFIS\u2013Institute for Information Technology , 26121 Oldenburg 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