{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:07:18Z","timestamp":1793390838971,"version":"4.5.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish government"},{"name":"ALF-agreement","award":["ALFGBG-997189"],"award-info":[{"award-number":["ALFGBG-997189"]}]},{"name":"ALF-agreement","award":["ALFGBG-1005815"],"award-info":[{"award-number":["ALFGBG-1005815"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the effect of treatment with glucagon-like peptide-1 receptor agonists (GLP1-RAs) on weight-related, metabolic, and reproductive outcomes and health economics in women with polycystic ovary syndrome (PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis, Prospero CRD42024535096<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cochrane Library, EMBASE, and Medline were searched on September 20, 2024 for studies including women with PCOS, comparing GLP1-RAs with no treatment, placebo, lifestyle intervention, combined oral contraceptives, antiandrogenic drugs, or metformin in randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9654 studies were identified, 365 read in full text and 11 RCTs were included. GLP1-RAs as an add-on showed a reduction in BMI compared to the control group, mean difference (95% CI), \u22121.38 (\u22122.39 to \u22120.38) kg\/m2 (low certainty). For LDL cholesterol and triglycerides, no difference was noted between the groups (low certainty), whereas evidence was insufficient to draw conclusion regarding glucose, insulin, hirsutism, and menstrual regularity. No studies were identified assessing quality of life, mental health, or cost-effectiveness outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GLP-1-RAs are associated with modest short-term weight loss in women with PCOS and overweight or obesity. Evidence for benefits on metabolic, reproductive, or psychological outcomes remains uncertain due to low-quality data, and no studies have evaluated cost-effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>The protocol for the systematic review was registered prospectively in Prospero, CRD42024535096.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag033","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:41:55Z","timestamp":1771072915000},"page":"S25-S39","source":"Crossref","is-referenced-by-count":18,"title":["GLP-1 receptor agonist treatment in women with polycystic ovary syndrome\u2014a systematic review and meta-analysis"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-3849","authenticated-orcid":false,"given":"Maria","family":"Forslund","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg SE-41345 ,","place":["Sweden"]},{"name":"Department of Gynecology and Reproduction, Sahlgrenska University Hospital , SE-41346 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"W\u00e4ndell","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Care Sciences and Society, Karolinska Institutet , SE-14183 Huddinge ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), SE-10233 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"\u00d6sterberg","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), SE-10233 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Dagerhamn","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), SE-10233 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Wernersson","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), SE-10233 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"K\u00e4rrman Fredriksson","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), SE-10233 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ringborg","sequence":"additional","affiliation":[{"name":"Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU), SE-10233 Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Lind\u00e9n Hirschberg","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Karolinska Institutet , SE-17176 Stockholm ,","place":["Sweden"]},{"name":"Department of Gynecology and Reproductive Medicine, Karolinska University Hospital , SE-17176 Stockholm 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