{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:01:26Z","timestamp":1784030486894,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["315921"],"award-info":[{"award-number":["315921"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["321763"],"award-info":[{"award-number":["321763"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["Profit6 336449"],"award-info":[{"award-number":["Profit6 336449"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013500","name":"Finnish Diabetes Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sakari Alhopuro Foundation"},{"DOI":"10.13039\/100016332","name":"Medical Research Center Oulu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is associated with high comorbidity risk, whereas the data on mortality are inconsistent. The objective was to investigate all-cause and cause-specific mortality risks in women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cohort study utilizing 1:3 matched cases and controls. The follow-up started at the diagnosis of PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All women with ICD 8-10 codes for PCOS during January, 1, 1969 to December, 31, 2019 were identified from Finnish nationwide health-care records (N = 9839). Women with PCOS were compared to age and residential area-at-birth-matched control women who did not have a PCOS diagnosis (N = 28 238). Crude and adjusted Cox proportional hazards models were fitted, adjusting for education level and diagnosed conditions (obesity, type 2 diabetes, and hypertension; yes vs no). The results were reported as hazard ratios (HRs) with 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the median follow-up time of 12\u2005years, 2.02% (n = 199\/9839) of women with PCOS had died compared to 1.43% (n = 403\/28 238) of controls. Women with PCOS had increased overall mortality after adjusting for education level, obesity, type 2 diabetes, and hypertension (adjusted HR = 1.33 [1.12-1.59]). Mortality due to neoplasms (education adjusted HR = 1.39 [1.04-1.86]) and diseases of the circulatory system (education adjusted HR = 1.68 [1.14-2.50]) was increased. Additionally, mortality due to endocrine, nutritional, and metabolic diseases was increased in the unadjusted model (HR = 2.48 [1.03-5.98]), but not in the education-adjusted model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that women with PCOS have an increased overall mortality compared to women without PCOS. Effective strategies to reduce mortality risk in women with PCOS should be investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag080","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:42:05Z","timestamp":1779882125000},"page":"724-731","source":"Crossref","is-referenced-by-count":1,"title":["Increased mortality in polycystic ovary syndrome\u2014 a cohort study"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-7300","authenticated-orcid":false,"given":"Terhi T","family":"Piltonen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oulu University Hospital , Oulu 90220 ,","place":["Finland"]},{"name":"Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu , Oulu 90220 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,","place":["Finland"]},{"name":"Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu , Oulu 90220 ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Hurskainen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oulu University Hospital , Oulu 90220 ,","place":["Finland"]},{"name":"Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu , Oulu 90220 ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7525","authenticated-orcid":false,"given":"Mika","family":"Gissler","sequence":"additional","affiliation":[{"name":"Department of Data and Analytics, Finnish Institute for Health and Welfare , PO Box 30, Helsinki 00271 ,","place":["Finland"]},{"name":"Region Stockholm, Academic Primary Health Care Centre , Stockholm 113 65 ,","place":["Sweden"]},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm 171 76 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-9293","authenticated-orcid":false,"given":"Riikka K","family":"Arffman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oulu University Hospital , Oulu 90220 ,","place":["Finland"]},{"name":"Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu , Oulu 90220 ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-0369","authenticated-orcid":false,"given":"Meri-Maija","family":"Ollila","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu , Oulu 90220 ,","place":["Finland"]},{"name":"Department of Internal Medicine, Oulu University Hospital , Oulu 90220 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