{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T18:07:32Z","timestamp":1779991652224,"version":"3.53.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404036"],"award-info":[{"award-number":["82404036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403074"],"award-info":[{"award-number":["82403074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Sichuan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025ZNSFSC1917"],"award-info":[{"award-number":["2025ZNSFSC1917"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Sichuan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025ZNSFSC1886"],"award-info":[{"award-number":["2025ZNSFSC1886"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The prognostic importance of tumor location in pheochromocytomas and paragangliomas (PPGLs) remains controversial. This study aimed to assess whether anatomic site independently influences survival in PPGLs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, population-based cohort using SEER 17 (2000-2022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with histologically confirmed PPGLs were categorized by the primary site as adrenal gland, head and neck, thorax, or abdomen. Overall and cancer-specific survival rates were analyzed using Kaplan\u2013Meier and multivariable Cox models, including stage-stratified analyses. Propensity score matching (PSM) was performed to minimize confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1468 patients, 55.9% had adrenal, 17.6% abdominal, 13.6% head and neck, and 12.8% thoracic tumors. Survival outcomes varied by site (P = .004), with head and neck PGLs showing the most favorable prognosis. Multivariable and stage-stratified models revealed no independent impact of site in localized disease, but significant differences emerged in regional and metastatic stages: head and neck tumors demonstrated superior outcomes in regional disease, while adrenal pheochromocytomas exhibited the poorest prognosis in distant disease (HR 2.26, 95% CI 1.14-4.48). PSM analyses confirmed that survival equivalence between adrenal and head and neck tumors in early-stage disease diverged upon metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prognostic effect of anatomic site in PPGLs is stage-dependent. While location does not influence outcomes in localized disease, it becomes clinically meaningful with progression\u2014favoring head and neck tumors and disadvantaging adrenal primaries in advanced stages. Incorporating site into stage-aware risk stratification and tailoring multimodal care for high-risk thoraco-abdominal\/adrenal disease are warranted. Prospective, genotype-annotated registries should validate and refine these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag084","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:19:30Z","timestamp":1779103170000},"page":"684-693","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of anatomic site in pheochromocytomas and paragangliomas: a population-based cohort study"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8297-3888","authenticated-orcid":false,"given":"Kan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital, Sichuan University , Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hexiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital, Sichuan University , Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"Breast Center, West China Hospital, Sichuan University , Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital, Sichuan University , Sichuan 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-7045","authenticated-orcid":false,"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital, Sichuan University , Sichuan 610041 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