{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T19:13:10Z","timestamp":1780686790238,"version":"3.54.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["325768017"],"award-info":[{"award-number":["325768017"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["314061271 TRR205"],"award-info":[{"award-number":["314061271 TRR205"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FBCRC-1665 \u2212515637292"],"award-info":[{"award-number":["FBCRC-1665 \u2212515637292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LMU Munich funding scheme"},{"name":"International Fund Congenital Adrenal Hyperplasia","award":["2023"],"award-info":[{"award-number":["2023"]}]},{"name":"Eva Luise und Horst K\u00f6hler Stiftung & Else Kr\u00f6ner-Fresenius-Stiftung","award":["2019_KollegSE.03"],"award-info":[{"award-number":["2019_KollegSE.03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate outcomes after switching from conventional glucocorticoids (GCs) to modified-release hydrocortisone (MR-HC; Efmody) in adults with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency under real-life conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, observational cohort study at a tertiary endocrine center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty-two adults with classic CAH (25 male; 42 salt-wasting) were switched to MR-HC and followed up for at least 12 months and up to 4 visits or until termination of treatment (median 23.5 months; visit 4 not yet completed in 6\/62). Outcomes included hormonal control, metabolic parameters, and menstrual patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, 42\/62 patients had androstenedione (A4) within the reference range, 13\/62 showed elevated concentrations, and 7\/62 had suppressed concentrations. At the last available visit, 11\/13 of patients with elevated A4 normalized. Salivary 17-hydroxyprogesterone decreased significantly in the early morning (P = .025), 12 Pm (P = .036) and 4 Pm (P = .042). Median hydrocortisone-equivalent dose declined from 30\u2005mg (IQR 25-37.5) to 25\u2005mg (IQR 20-30) (P &amp;lt; .001). HOMA-IR improved (2.15-1.67; P = .023), while other metabolic parameters remained stable. Daytime blood systolic and diastolic pressure decreased by \u223c5\u2005mmHg (P = .007 and P = .003). Fludrocortisone was reduced in 12\/41 (29.3%) salt-wasting patients. Among women with menstrual disturbances (12\/42), 6\/12 normalized and 1\/12 conceived; among women with regular cycles, 3\/12 developed irregular cycles or amenorrhea. The adrenal crisis rate was 5.0 per 100 patient-years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MR-HC enabled stable biochemical control with reduced GC exposure and was associated with improvements in insulin sensitivity, blood pressure, and menstrual regularity, supporting its role as a safe and physiological treatment option in adults with CAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag087","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:30:50Z","timestamp":1779017450000},"page":"806-818","source":"Crossref","is-referenced-by-count":0,"title":["Real-world outcomes with modified-release hydrocortisone in classic congenital adrenal hyperplasia"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-8332","authenticated-orcid":false,"given":"Matthias K","family":"Auer","sequence":"first","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Bayer","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna F","family":"Nowotny","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Tschaidse","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsela","family":"Dervishi","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Christin","family":"Welp","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-4392","authenticated-orcid":false,"given":"Christian","family":"Lottspeich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-6668","authenticated-orcid":false,"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Kunz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7469-6069","authenticated-orcid":false,"given":"Nicole","family":"Reisch","sequence":"additional","affiliation":[{"name":"Medizinische Klinik and Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen, LMU M\u00fcnchen , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"issue":"10372","key":"2026060514585341800_lvag087-B1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0140-6736(22)01330-7","article-title":"Congenital adrenal hyperplasia","volume":"401","author":"Auer","year":"2023","journal-title":"Lancet"},{"issue":"3","key":"2026060514585341800_lvag087-B2","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1210\/jc.2014-3809","article-title":"A phase 2 study of Chronocort, a modified-release formulation of hydrocortisone, in the treatment of adults with classic congenital adrenal hyperplasia","volume":"100","author":"Mallappa","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"3):","key":"2026060514585341800_lvag087-B3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1111\/cen.15275","article-title":"Switching patients with congenital adrenal hyperplasia to modified-release hydrocortisone capsules: relative bioavailability and disease control","volume":"103","author":"Ross","year":"2025","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"1):","key":"2026060514585341800_lvag087-B4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/ejendo\/lvaf130","article-title":"Long-term outcomes in patients with congenital adrenal hyperplasia treated with hydrocortisone modified-release hard capsules","volume":"193","author":"Arlt","year":"2025","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"2026060514585341800_lvag087-B5","doi-asserted-by":"publisher","first-page":"e2063","DOI":"10.1210\/clinem\/dgab051","article-title":"Modified-release hydrocortisone in congenital adrenal hyperplasia","volume":"106","author":"Merke","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"issue":"12","key":"2026060514585341800_lvag087-B6","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.2337\/diacare.21.12.2191","article-title":"Correct homeostasis model assessment (HOMA) evaluation uses the computer program","volume":"21","author":"Levy","year":"1998","journal-title":"Diabetes Care"},{"key":"2026060514585341800_lvag087-B7","doi-asserted-by":"publisher","author":"Tallarida","DOI":"10.1007\/978-1-4612-4974-0_26"},{"issue":"12","key":"2026060514585341800_lvag087-B8","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1210\/jc.2012-2102","article-title":"Clinical characteristics of a cohort of 244 patients with congenital adrenal hyperplasia","volume":"97","author":"Finkielstain","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2026060514585341800_lvag087-B9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jhep.2009.05.023","article-title":"Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance","volume":"51","author":"Schwenzer","year":"2009","journal-title":"J Hepatol."},{"issue":"1","key":"2026060514585341800_lvag087-B10","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-230X-6-33","article-title":"The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population","volume":"6","author":"Bedogni","year":"2006","journal-title":"BMC Gastroenterol"},{"key":"2026060514585341800_lvag087-B11","volume-title":"Medical Eligibility Criteria for Contraceptive Use","author":"World Health Organization","year":"2010"},{"issue":"5","key":"2026060514585341800_lvag087-B12","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1210\/jc.2017-00131","article-title":"Functional hypothalamic amenorrhea: an endocrine society clinical practice guideline","volume":"102","author":"Gordon","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2026060514585341800_lvag087-B13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.25080\/Majora-92bf1922-00a","article-title":"Data structures for statistical computing in Python","volume":"445","author":"McKinney","year":"2010","journal-title":"SciPy"},{"issue":"3","key":"2026060514585341800_lvag087-B14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1109\/MCSE.2007.55","article-title":"Matplotlib: a 2D graphics environment","volume":"9","author":"Hunter","year":"2007","journal-title":"Comput Sci Eng."},{"issue":"60","key":"2026060514585341800_lvag087-B15","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"Seaborn: statistical data visualization","volume":"6","author":"Waskom","year":"2021","journal-title":"J Open Source Softw."},{"issue":"3","key":"2026060514585341800_lvag087-B16","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1210\/jcem.85.3.6441","article-title":"Predicting phenotype in steroid 21-hydroxylase deficiency? Comprehensive genotyping in 155 unrelated, well defined patients from southern Germany","volume":"85","author":"Krone","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026060514585341800_lvag087-B17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1530\/EJE-12-0161","article-title":"Frequency and causes of adrenal crises over lifetime in patients with 21-hydroxylase deficiency","volume":"167","author":"Reisch","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2026060514585341800_lvag087-B18","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/ejendo\/lvae023","article-title":"Frequency of stress dosing and adrenal crisis in paediatric and adult patients with congenital adrenal hyperplasia: a prospective study","volume":"190","author":"Tschaidse","year":"2024","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2026060514585341800_lvag087-B19","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s12020-016-1204-2","article-title":"Adrenal crises: perspectives and research directions","volume":"55","author":"Rushworth","year":"2017","journal-title":"Endocrine"},{"issue":"11","key":"2026060514585341800_lvag087-B20","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline","volume":"103","author":"Speiser","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2026060514585341800_lvag087-B21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2174\/1573398052953604","article-title":"Clinical potencies of glucocorticoids: what do we really measure?","volume":"1","author":"Dubois","year":"2005","journal-title":"Curr Respir Med Rev."},{"issue":"6","key":"2026060514585341800_lvag087-B22","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1530\/EJE-15-0064","article-title":"Hormonal circadian rhythms in patients with congenital adrenal hyperplasia: identifying optimal monitoring times and novel disease biomarkers","volume":"173","author":"Debono","year":"2015","journal-title":"Eur J Endocrinol."},{"issue":"11","key":"2026060514585341800_lvag087-B23","doi-asserted-by":"publisher","first-page":"e4509","DOI":"10.1210\/clinem\/dgab446","article-title":"Salivary profiles of 11-oxygenated androgens follow a diurnal rhythm in patients with congenital adrenal hyperplasia","volume":"106","author":"Nowotny","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2026060514585341800_lvag087-B24","doi-asserted-by":"publisher","first-page":"5110","DOI":"10.1210\/jc.2010-0917","article-title":"Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients","volume":"95","author":"Arlt","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2026060514585341800_lvag087-B25","doi-asserted-by":"publisher","first-page":"105749","DOI":"10.1016\/j.ebiom.2025.105749","article-title":"Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia","volume":"116","author":"Lawrence","year":"2025","journal-title":"EBioMedicine"},{"issue":"2","key":"2026060514585341800_lvag087-B26","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1530\/EJE-10-0877","article-title":"Cardiovascular risk, metabolic profile, and body composition in adult males with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"164","author":"Falhammar","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026060514585341800_lvag087-B27","doi-asserted-by":"publisher","first-page":"bvae211","DOI":"10.1210\/jendso\/bvae211","article-title":"Women with congenital adrenal hyperplasia have favorable pregnancy outcomes but prolonged time to conceive","volume":"9","author":"Auer","year":"2024","journal-title":"J Endocr Soc"},{"key":"2026060514585341800_lvag087-B28","doi-asserted-by":"publisher","first-page":"105540","DOI":"10.1016\/j.jsbmb.2019.105540","article-title":"Effect of androgen excess and glucocorticoid exposure on metabolic risk profiles in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"197","author":"Paizoni","year":"2020","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2026060514585341800_lvag087-B29","doi-asserted-by":"publisher","first-page":"E36","DOI":"10.1152\/ajpendo.1996.270.1.E36","article-title":"Effects of morning cortisol elevation on insulin secretion and glucose regulation in humans","volume":"270","author":"Plat","year":"1996","journal-title":"Am J Physiol Endocrinol Metab."},{"issue":"5","key":"2026060514585341800_lvag087-B30","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1172\/JCI116832","article-title":"Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans","volume":"92","author":"Dinneen","year":"1993","journal-title":"J Clin Invest."},{"issue":"3","key":"2026060514585341800_lvag087-B31","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s40618-022-01940-1","article-title":"Benefits of dual-release hydrocortisone treatment on central adiposity and health-related quality of life in secondary adrenal insufficiency","volume":"46","author":"Gasco","year":"2023","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"2026060514585341800_lvag087-B32","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1007\/s12020-024-03711-9","article-title":"Dual-release hydrocortisone improves body composition and the glucometabolic profile in patients with secondary adrenal insufficiency","volume":"84","author":"J\u00f8rgensen","year":"2024","journal-title":"Endocrine"},{"issue":"2","key":"2026060514585341800_lvag087-B33","doi-asserted-by":"publisher","first-page":"R66","DOI":"10.1530\/EC-20-0473","article-title":"The use of prednisolone versus dual-release hydrocortisone in the treatment of hypoadrenalism","volume":"10","author":"Choudhury","year":"2021","journal-title":"Endocr Connect"},{"issue":"3","key":"2026060514585341800_lvag087-B34","doi-asserted-by":"publisher","first-page":"e566","DOI":"10.1210\/clinem\/dgae822","article-title":"Extended-release hydrocortisone formulations\u2014is there a clinically meaningful benefit?","volume":"110","author":"Steintorsdottir","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"1):","key":"2026060514585341800_lvag087-B35","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s12020-025-04328-2","article-title":"Impact of dual-release hydrocortisone on disease control and metabolism in congenital adrenal hyperplasia: a retrospective cohort study","volume":"90","author":"Mazzeo","year":"2025","journal-title":"Endocrine"},{"issue":"11","key":"2026060514585341800_lvag087-B36","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.1210\/jc.2018-01862","article-title":"Cardiovascular and metabolic outcomes in congenital adrenal hyperplasia: a systematic review and meta-analysis","volume":"103","author":"Tamhane","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026060514585341800_lvag087-B37","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1210\/jc.2011-1926","article-title":"Improved cortisol exposure-time profile and outcome in patients with adrenal insufficiency: a prospective randomized trial of a novel hydrocortisone dual-release formulation","volume":"97","author":"Johannsson","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2026060514585341800_lvag087-B38","doi-asserted-by":"publisher","first-page":"lvac006","DOI":"10.1093\/ejendo\/lvac006","article-title":"Modified-release hydrocortisone is associated with lower plasma renin activity in patients with salt-wasting congenital adrenal hyperplasia","volume":"188","author":"Tschaidse","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2026060514585341800_lvag087-B39","doi-asserted-by":"publisher","first-page":"dgz055","DOI":"10.1210\/clinem\/dgz055","article-title":"Plasma renin measurements are unrelated to mineralocorticoid replacement dose in patients with primary adrenal insufficiency","volume":"105","author":"Pofi","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"2026060514585341800_lvag087-B40","doi-asserted-by":"publisher","first-page":"105921","DOI":"10.1016\/j.jsbmb.2021.105921","article-title":"11-oxygenated androgens and their relation to hypothalamus-pituitary-gonadal-axis disturbances in adults with congenital adrenal hyperplasia","volume":"212","author":"Auer","year":"2021","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"3","key":"2026060514585341800_lvag087-B41","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.ecl.2024.05.005","article-title":"Pregnancy in congenital adrenal hyperplasia","volume":"53","author":"Reisch","year":"2024","journal-title":"Endocrinol Metab Clin North Am"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvag087\/68341469\/lvag087.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/194\/6\/806\/68341469\/lvag087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/194\/6\/806\/68341469\/lvag087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:59:00Z","timestamp":1780685940000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/194\/6\/806\/8687786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvag087","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,5,19]]}}}