{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:12:06Z","timestamp":1780665126684,"version":"3.54.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2022-138243OB-I00"],"award-info":[{"award-number":["PID2022-138243OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["MICIU\/AEI"],"award-info":[{"award-number":["MICIU\/AEI"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Spanish pharmacovigilance alerts have highlighted vitamin D overdosing. We retrospectively analysed adult serum 25(OH)D results from a Barcelona tertiary hospital (2020-2025), measured using a VDSCP-certified immunoassay. For results &amp;gt;100\u2005ng\/mL (250\u2005nmol\/L), concomitant calcium, phosphorus, albumin, alkaline phosphatase and parathyroid hormone were retrieved. Hypercalcemia was defined as albumin-corrected calcium &amp;gt;10.5\u2005mg\/dL. Among 185 604 results, annual testing increased by 54.1% and median 25(OH)D rose from 25.3 to 28.6\u2005ng\/mL. Very high results more than doubled (31 [0.14%] to 108 [0.31%]; n = 393). Calcium was available in 324\/393 results, and hypercalcemia occurred in 14\/324 (4.3%). Calcifediol was documented in 183\/201 (91.0%) hypervitaminosis D patients with available supplementation data and in 12\/14 (85.7%) hypercalcemic cases, often in short-interval dosing regimens. Rapid test growth paralleled a rightward shift and expanding high-concentration tail, supporting evidence-based requesting, clearer intermittent-dosing and supplementation instructions, and selective serum calcium surveillance when 25(OH)D is greatly elevated.<\/jats:p>","DOI":"10.1093\/ejendo\/lvag088","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:30:49Z","timestamp":1779017449000},"page":"K21-K25","source":"Crossref","is-referenced-by-count":0,"title":["Overdiagnosed and oversupplemented: the iatrogenic rise of vitamin D toxicity"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-0306","authenticated-orcid":false,"given":"Aleix B","family":"Fabregat-Bolufer","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Biomedical Diagnostic Center (CDB), Hospital Cl\u00ednic de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7192-5002","authenticated-orcid":false,"given":"Carlos","family":"Mart\u00edn-Alonso","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Biomedical Diagnostic Center (CDB), Hospital Cl\u00ednic de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-4287","authenticated-orcid":false,"given":"Alba","family":"Escol\u00e0-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Division of Medicines, Hospital Cl\u00ednic de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9074-2272","authenticated-orcid":false,"given":"Manuel","family":"Morales-Ruiz","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Genetics Department, Biomedical Diagnostic Center (CDB), Hospital Cl\u00ednic de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona-Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]},{"name":"Centre for Biomedical Research Network on Liver and Digestive Diseases (CIBERehd) , 28029 Madrid, Community of Madrid ,","place":["Spain"]},{"name":"Biomedicine Department, Faculty of Medicine and Health Sciences, Universitat de Barcelona , 08036 Barcelona, Catalonia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2026060508563255000_lvag088-B1","author":"Agencia Espa\u00f1ola de Medicamentos y Productos Sanitarios (AEMPS)"},{"key":"2026060508563255000_lvag088-B2","author":"Trejo Su\u00e1rez"},{"key":"2026060508563255000_lvag088-B3","author":"Ministerio de Sanidad (Espa\u00f1a)"},{"key":"2026060508563255000_lvag088-B4","doi-asserted-by":"publisher","first-page":"120155","DOI":"10.1016\/j.cca.2025.120155","article-title":"Redefining vitamin D status: establishing population-based indirect reference intervals through big data analysis","volume":"569","author":"Fabregat-Bolufer","year":"2025","journal-title":"Clin Chim Acta"},{"issue":"5","key":"2026060508563255000_lvag088-B5","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1093\/jalm\/jfaf084","article-title":"Data-driven reference intervals in modern laboratory medicine: new web tools to refine vitamin D status","volume":"10","author":"Barrag\u00e1n Mu\u00f1oz","year":"2025","journal-title":"J Appl Lab Med"},{"issue":"1","key":"2026060508563255000_lvag088-B6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2026060508563255000_lvag088-B7","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol 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primary care in the UK: a retrospective analysis of the health improvement network (THIN), 2005-2015","volume":"9","author":"Crowe","year":"2019","journal-title":"BMJ Open"}],"container-title":["European Journal of 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