{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:00:54Z","timestamp":1791302454399,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007311","name":"German Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["DKS 2021.11"],"award-info":[{"award-number":["DKS 2021.11"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007311","name":"German Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["DKS 2024.16"],"award-info":[{"award-number":["DKS 2024.16"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007311","name":"German Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["DKS 2025.07"],"award-info":[{"award-number":["DKS 2025.07"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007311","name":"German Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["DKS 2025.16"],"award-info":[{"award-number":["DKS 2025.16"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007311","name":"German Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["101248798"],"award-info":[{"award-number":["101248798"]}],"id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research","doi-asserted-by":"publisher","award":["KFS-5992-595908-2023"],"award-info":[{"award-number":["KFS-5992-595908-2023"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CANSEARCH Foundation"},{"name":"Childhood Cancer Research Switzerland"},{"name":"Bernese Foundation for Children and Adolescents with Cancer"},{"name":"Zo\u00e94life"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map real-world management of paediatric differentiated thyroid carcinoma (DTC) across Europe and identify targets for harmonization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional, web-based survey of centres providing paediatric DTC care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting &amp; Participants<\/jats:title>\n                    <jats:p>One consolidated response per centre was requested from a clinician overseeing paediatric DTC. The instrument covered centre profile\/multidisciplinary tumour (MDT) board organization; staging and guideline use; risk stratification and dynamic response; diagnostics; surgery\/lymph node management; radioactive iodine therapy (RAIT) policy and activity selection; and thyroid-stimulating hormone targets, follow-up, shared-care\/transition. Analyses were descriptive at centre level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-two centres from 18 countries participated in the survey. Response denominators varied by item. Among responding centres, \u224875% were university or academic hospitals, \u224870% used a paediatric age cut-off of \u226418 years, and \u224860% reported having a dedicated MDT board. Staging and guideline use were heterogeneous: centres most often reported mixed or centre-specific guidance, followed by the American Thyroid Association (ATA) 2015 guideline, national guidelines, and the European Thyroid Association (ETA) 2022 guideline. Dynamic response-to-therapy categories were commonly used. For unilateral presumed low-risk disease, hemithyroidectomy was the usual initial surgery in approximately two-thirds to three-quarters of centres, whereas total thyroidectomy was less common. For low-risk patients, RAIT policy were split between de-escalation and risk-adapted use. When administered, RAIT activity was determined using weight-based, dosimetric, or fixed empirical approaches. Country-level patterns suggested clustering around ETA-leaning, ATA-leaning, and national guideline frameworks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Across Europe, centres broadly endorse risk-adapted care but diverge at key decision nodes\u2014extent of surgery, formal risk framework, and RAIT in low-risk disease\u2014reflecting guidance plurality and organizational context. Leveraging existing infrastructures offers pragmatic avenues to reduce unwarranted variation while generating paediatric-specific evidence to refine recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag091","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:08:17Z","timestamp":1778760497000},"page":"756-768","source":"Crossref","is-referenced-by-count":0,"title":["Who leads, who treats, what dose? European paediatric differentiated thyroid carcinoma practice\u2014an European Cooperative Study Group for Paediatric Rare Tumours survey"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-0503","authenticated-orcid":false,"given":"Michaela","family":"Kuhlen","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Paediatric Haematology\/Oncology, Otto-von-Guericke-University , Magdeburg-D 39120 ,","place":["Germany"]},{"name":"Paediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg , Augsburg ,","place":["Germany"]},{"name":"Bavarian Cancer Research Centre (BZKF) , Augsburg-D 86156 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-6069","authenticated-orcid":false,"given":"Jelena","family":"Roganivic","sequence":"additional","affiliation":[{"name":"Children's Hospital Zagreb, Department of Pediatric Oncology and Haematology , Zagreb 10000 ,","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Naviglio","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo,\u201d University of Trieste, Trieste ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-2912","authenticated-orcid":false,"given":"Fredrik","family":"Baecklund","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit, Karolinska University Hospital , Stockholm 171 64 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bello","sequence":"additional","affiliation":[{"name":"The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel , Petach Tikva ,","place":["Israel"]},{"name":"Gray Faculty for Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0017-6332","authenticated-orcid":false,"given":"Tal","family":"Ben-Ami","sequence":"additional","affiliation":[{"name":"Paediatric Haematology\/Oncology Unit, Kaplan Medical Centre , Rehovot 7661041 , , affiliated with Hadassah-Hebrew University Medical School, Jerusalem, Israel","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-329X","authenticated-orcid":false,"given":"Luca","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori , Milan 20133 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