{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:25:41Z","timestamp":1793053541580,"version":"4.5.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health and Welfare of the Republic of Korea","award":["RS-2025-02233101"],"award-info":[{"award-number":["RS-2025-02233101"]}]},{"name":"Patient-Centered Clinical Research Coordinating Center"},{"name":"PACEN"},{"name":"Ministry of Health and Welfare of the Republic of Korea","award":["RS-2024-00397426"],"award-info":[{"award-number":["RS-2024-00397426"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Catecholamine excess in pheochromocytoma may contribute to elevated serum cortisol concentration. However, the clinical characteristics and cardiometabolic effects of concurrent non-suppressed cortisol concentration remain unclear<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective multicenter cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Among 806 patients with pheochromocytoma from 5 tertiary centers, 389 who underwent a 1-mg overnight dexamethasone suppression test (ODST) were included. Non-suppressed cortisol was defined as a post-ODST cortisol concentration &amp;gt;1.8 \u03bcg\/dL. Clinical and tumor characteristics were compared between patients with and without non-suppressed cortisol. Correlations between post-ODST cortisol concentration and catecholamine concentrations were analyzed. Logistic regression analyses identified factors associated with type 2 diabetes mellitus (T2DM) and hypertension (HTN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Non-suppressed cortisol was identified in 144 patients (37.0%). Despite comparable body mass index (BMI) (22.9 vs. 23.6\u2005kg\/m2, P = .050), patients with non-suppressed cortisol had more frequent HTN (61.1% vs. 46.1%, P = .004) and T2DM (31.3% vs. 17.1%, P = .001), larger tumors (4.0 vs. 3.6\u2005cm, P = .021), and more frequent bilaterality (9.7% vs. 4.1%, P = .026). Post-ODST cortisol concentration was positively correlated with plasma metanephrine (r = 0.148, P = .011) and normetanephrine (r = 0.141, P = .016). Non-suppressed cortisol was independently associated with T2DM (odds ratio [OR] = 2.072; 95% confidence interval [CI] = 1.137-3.777; P = .017) and HTN (OR = 1.905; 95% CI = 1.079-3.361; P = .026).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Larger tumor size, bilaterality, and higher plasma metanephrine and normetanephrine levels were associated with non-suppressed post-ODST cortisol. Post-ODST cortisol &amp;gt;1.8 \u03bcg\/dL in patients with pheochromocytoma was independently linked to a higher prevalence of T2DM and HTN, suggesting an additive cardiometabolic burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag093","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:23:34Z","timestamp":1779103414000},"page":"769-777","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics and cardiometabolic association of non-suppressed cortisol after dexamethasone suppression test in patients with pheochromocytoma"],"prefix":"10.1093","volume":"194","author":[{"given":"Min Jeong","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Korea University Medical Center Guro Hospital , Seoul 08308 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Ram","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University Medical School , Gwangju 61186 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Hee","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine , Incheon 22232 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University College of Medicine , Daejeon 34134 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Shin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine , 101 Dae-hak ro, Seoul 03080 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Yeun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine , Seoul 01830 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9074-8087","authenticated-orcid":false,"given":"Jeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Eunpyeong St.Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul 03312 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eu Jeong","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul National University College of 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