{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:25:50Z","timestamp":1791563150160,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer risk in acromegaly remains debated, with studies showing both increased and similar risk compared to the background population. We conducted a nationwide cohort study examining the risk of cancer and benign colorectal lesions in acromegaly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included acromegaly patients diagnosed in Denmark (1977-2021, n = 809, median follow-up 12.2 [IQR: 5.6-21.7] years (range: 0.04-44.0) and controls matched on sex and birth year (n = 80 900). All diagnoses of acromegaly were biochemically validated. We investigated the occurrence of cancer diagnoses, benign colorectal lesions, performance of colonoscopies and mortality with time-to-event statistics and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Overall cancer risk was not clearly increased (IRR: 1.10 [0.93;1.30], P = .27), but patients with acromegaly had an increased risk of colorectal cancer (IRR: 1.78 [1.22;2.60], P &amp;lt; .01) and thyroid cancer (IRR: 3.68 [1.16;11.66], P = .03). Colorectal cancers were more often localized (IRR: 2.00 [1.21;3.30], P = .007) as compared to controls, and the use of endoscopic colorectal procedures was increased (IRR: 2.85 [2.54;3.19], P &amp;lt; .01). The incidence of benign colorectal lesions was elevated in acromegaly patients (IRR: 2.32 [1.96;2.76], P &amp;lt; .01) and dominated by tubular adenomas (43.6%) and hyperplastic polyps (33.2%). Fecal immunochemical test (FIT) screening and clinical suspicion guided the use of colonoscopies, rather than systematic colonoscopy screening. All-cause mortality was elevated in acromegaly (IRR: 1.18 [1.02; 1.36], P = .03), but cancer-specific mortality was not (IRR: 0.95 [0.72;1.25], P = .72).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Acromegaly carries an increased risk of colorectal cancer, but neither overall cancer risk nor cancer-specific mortality is increased.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag121","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:34:11Z","timestamp":1783334051000},"page":"138-151","source":"Crossref","is-referenced-by-count":2,"title":["Long-term cancer risk in acromegaly: a population-based cohort study with 44 years of follow-up"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-4387","authenticated-orcid":false,"given":"Christian","family":"Rosendal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , 9260 Gistrup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Christiansen Arlien-S\u00f8borg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , 8200 Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Skovsager","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital , 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Larsen","family":"Feltoft","sequence":"additional","affiliation":[{"name":"Department of Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte Hospital , 2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6075-0821","authenticated-orcid":false,"given":"Marianne","family":"Klose","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Henrik","family":"Bruun","sequence":"additional","affiliation":[{"name":"Research Data and Biostatistics, Aalborg University Hospital , 9000 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eigil Husted","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , 9260 Gistrup ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-7580","authenticated-orcid":false,"given":"Olaf M","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Leiden University Medical Center , 2333 Leiden ,","place":["The Netherlands"]},{"name":"Department of Endocrinology, Leiden University Medical Center , 2333 Leiden ,","place":["The Netherlands"]},{"name":"Aarhus KEA, Aarhus University Hospital , 8200 Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7408-1526","authenticated-orcid":false,"given":"Jens Otto Lunde","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , 8200 Aarhus 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