{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:04:23Z","timestamp":1784574263271,"version":"3.55.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100008426","name":"Friedrich-Baur-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Adrenal: Central Relay in Health and Disease"},{"name":"German Cushing\u2019s Registry CUSTODES"},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","award":["2012_A103"],"award-info":[{"award-number":["2012_A103"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","award":["2015_A228"],"award-info":[{"award-number":["2015_A228"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius Stiftung","doi-asserted-by":"publisher","award":["2024_EKEA.153"],"award-info":[{"award-number":["2024_EKEA.153"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>MicroRNAs (miRNAs) have been identified to regulate gene expression in adrenal disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of specific miRNAs on cortisol biosynthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seven candidate miRNAs were transfected as mimics into steroidogenically active adrenocortical cell lines (NCI-H295R, HAC15, and CU-ACC1). Steroids were measured by liquid chromatography tandem mass spectrometry (LC-MS\/MS) and ELISA. Quantitative polymerase chain reaction was performed in all cell lines with additionally microarray analysis in HAC15 cells. Adrenal RNA-sequencing data from patients with Cushing's syndrome (CS, n = 10) and normal controls (n = 8) were analyzed to compare differentially expressed genes (DEGs) and enrichments. miRNA inhibitors were further used for validation<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>miR-486-5p and miR-144-3p mimics reduced cortisol levels by \u223c60%-70% in NCI-H295R and HAC15 cells, and LC-MS\/MS confirmed reduced steroidogenic metabolites. Both miR-486-5p and miR-144-3p mimics significantly inhibited CYP17A1 and CYP11B2 mRNA levels in NCI-H295R and HAC15 cells. Microarray analysis revealed the DEGs induced by miR-486-5p or miR-144-3p both predominantly enriched in \u201cMetabolic Pathways,\u201d consistent with enrichment in the CS adrenal dataset. Common metabolic genes (co-DEGs) between patient samples and miRNA mimic\u2013treated cells exhibited complementary expression patterns. Cotransfection of the corresponding inhibitors attenuated cortisol suppression and metabolic gene changes. Protein\u2013protein interaction analysis further clustered the miR-486-5p- and miR-144-3p-associated co-DEGs into lipid metabolism\u2013related biological process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>miR-486-5p and miR-144-3p suppress cortisol production in the human adrenocortical cell models of NCI-H295R and its derived HAC15 subclone and are associated with lipid metabolism\u2013related networks, providing new insights into the molecular regulation of cortisol biosynthesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag122","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:36:13Z","timestamp":1783424173000},"page":"152-164","source":"Crossref","is-referenced-by-count":0,"title":["miR-486-5p and miR-144-3p as candidate regulators of cortisol biosynthesis: functional and transcriptomic evidence in adrenocortical cells"],"prefix":"10.1093","volume":"195","author":[{"given":"Xiaohui","family":"Xia","sequence":"first","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU-Klinikum, Ludwig-Maximilians-University , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , W\u00fcrzburg 97080 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University , Suzhou 215000 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LMU-Klinikum, Ludwig-Maximilians-University , Munich 80336 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-5533","authenticated-orcid":false,"given":"Silviu","family":"Sbiera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , W\u00fcrzburg 97080 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-7435","authenticated-orcid":false,"given":"Anna","family":"Riester","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, LMU-Klinikum, Ludwig-Maximilians-University , Munich 80336 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