{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:51:26Z","timestamp":1785855086361,"version":"3.56.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020643","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIHR\/Wellcome Trust Imperial Clinical Research Facility"},{"DOI":"10.13039\/501100013342","name":"NIHR\/Imperial Biomedical Research Centre","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a protocol for chronic kisspeptin administration that persistently stimulates gonadotropin secretion. We evaluated the effects of acute and chronic subcutaneous kisspeptin-10 administration on reproductive hormones in healthy men to (1) characterize the acute dose\u2013\u2013response relationship to subcutaneous kisspeptin-10 infusion, (2) assess the effects of continuous kisspeptin-10 infusion over 5 days, and (3) daily intermittent administration (8 h on, 16 h off) for 12 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized, single-blinded, placebo-controlled study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Overall, 15 healthy men were recruited (study 1: n = 7, study 2: n = 4; study 3: n = 7); 12 men served as controls. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were assessed during an acute 8 h dose\u2013response subcutaneous kisspeptin-10 infusions (1.25\u201310.0\u2005nmol\/kg\/h). Thereafter, we evaluated chronic subcutaneous administration, including continuous kisspeptin-10 infusion at 180\u2005nmol\/h for 5 days, and daily 8 h infusions at 150\u2005nmol\/h for 12 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(1) Acute subcutaneous kisspeptin-10 infusions dose-dependently increased LH, FSH, and testosterone vs vehicle (P &amp;lt; .0001). (2) Although testosterone concentrations remained elevated after 5 days of continuous kisspeptin-10, gonadotropin concentrations were similar to vehicle. (3) Daily 8\u2005h subcutaneous infusions over 12 days sustained increases in gonadotropins (mean LH increase: vehicle \u22120.16 \u00b1 0.19; day 1: +1.68 \u00b1 0.25; day 12: +1.14 \u00b1 0.33, P = .003 vs vehicle). Following 12 days, gonadotropin rises were still detected after kisspeptin-10 bolus (1\u2005nmol\/kg) indicating that the kisspeptin receptor remained functional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate that chronic subcutaneous kisspeptin administration sustains gonadotropin and testosterone secretion in healthy men for 12 days. These data can inform development of chronic kisspeptin administration protocols for the treatment of reproductive disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag134","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T11:34:20Z","timestamp":1785670460000},"page":"206-216","source":"Crossref","is-referenced-by-count":0,"title":["Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men"],"prefix":"10.1093","volume":"195","author":[{"given":"Arthur C","family":"Yeung","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United 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,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovanna","family":"Tsoutsouki","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhi W","family":"Nyunt","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Young","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaran H","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Daniels","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aureliane C S","family":"Pierret","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard G","family":"Mills","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N","family":"Comninos","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-5256","authenticated-orcid":false,"given":"Ali","family":"Abbara","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-4316","authenticated-orcid":false,"given":"Waljit S","family":"Dhillo","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital , London W12 0NN ,","place":["United Kingdom"]},{"name":"Department of Endocrinology, Imperial College Healthcare NHS Trust , London W6 8RF ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"2","key":"2026080410031311300_lvag134-B1","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/humupd\/dmn058","article-title":"The role of kisspeptin in the control of gonadotrophin secretion","volume":"15","author":"Roseweir","year":"2009","journal-title":"Hum Reprod Update"},{"issue":"19","key":"2026080410031311300_lvag134-B2","doi-asserted-by":"publisher","first-page":"10972","DOI":"10.1073\/pnas.1834399100","article-title":"Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor 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