{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:28:24Z","timestamp":1786368504619,"version":"build-2736575974"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Low bone mineral density (BMD) has been reported in individuals with complete androgen insensitivity syndrome (CAIS), but data on bone health, particularly on morphometric fractures, remain limited and heterogeneous. This study aimed to comprehensively assess bone health in a large monocentric cohort of adult women with CAIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study including 46 adults with CAIS (age 34 \u00b1 8.7\u2005years), 41 gonadectomized and 5 with gonads (age 34.6 \u00b1 8.4 and 29.6 \u00b1 7.5\u2005years, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bone health was assessed through dual-energy X-ray absorptiometry, vertebral morphometry and bone turnover markers. Hormonal levels and additional risk factors (eg, celiac disease, calcium and vitamin D intake) were evaluated. Among gonadectomized patients, all but 4 were receiving hormonal replacement therapy (HRT): 16 transdermal estradiol, 17 oral estradiol, and 4 testosterone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Lumbar spine BMD resulted impaired (mean Z-score = \u22121.78 \u00b1 1) in both groups, with Z-score &amp;lt;\u22122 in 47.8% of the cohort. Femoral BMD was less affected (total hip \u22120.6 \u00b1 1, femoral neck \u22120.77 \u00b1 1), particularly in those with gonads. Fragility fractures rate was 8.7% (median age = 39\u2005years). Bone turnover markers resulted increased compared with age-matched controls. No significant differences were found among HRT regimes. To enhance statistical power, retrospective BMD data from 27 additional individuals with CAIS were included. The expanded sub-analysis on 73 women confirmed no significant differences in BMD across HRT regimes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Young adults with CAIS show impaired lumbar BMD and a notable prevalence of fragility fractures, with similar findings across gonadectomy status and HRT regimen. Treatment should be optimized considering hormonal levels and BMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvag136","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:57:24Z","timestamp":1786017444000},"page":"229-236","source":"Crossref","is-referenced-by-count":0,"title":["Bone health in complete androgen insensitivity syndrome: a comprehensive assessment in a large adult cohort"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-1530","authenticated-orcid":false,"given":"Eriselda","family":"Profka","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan , 20122 Milan ,","place":["Italy"]},{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan 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Cristina","family":"Meriggiola","sequence":"additional","affiliation":[{"name":"Division of Gynecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna , 40138 Bologna ,","place":["Italy"]},{"name":"Department of Medical and Surgical Sciences (DIMEC), University of Bologna , 40138 Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Balzo","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Restelli","sequence":"additional","affiliation":[{"name":"Gynecology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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