{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:50:05Z","timestamp":1777945805415,"version":"3.51.4"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,2]]},"DOI":"10.1093\/ejhf\/xuag019","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:33:56Z","timestamp":1768566836000},"page":"108-110","source":"Crossref","is-referenced-by-count":0,"title":["Possible ways of building trial-level evidence for heart failure therapies in cardiac amyloidosis"],"prefix":"10.1093","volume":"28","author":[{"given":"Alberto","family":"Aimo","sequence":"first","affiliation":[{"name":"Interdisciplinary Center for Health Sciences, Scuola Superiore Sant\u2019Anna , Piazza Martiri della Libert\u00e0 33, Pisa 56127 ,","place":["Italy"]},{"name":"Cardiology Division, Fondazione Toscana Gabriele Monasterio , via Moruzzi 1, 56124 Pisa ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-2857","authenticated-orcid":false,"given":"Daniela","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"ASST Spedali Civili di Brescia and University of Brescia , Brescia ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Fontana","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, University College London , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"2026050209114581000_xuag019-B1","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1093\/eurheartj\/ehaf667","article-title":"Transthyretin amyloid cardiomyopathy: from cause to novel treatments","volume":"47","author":"Fontana","year":"2026","journal-title":"Eur Heart J"},{"key":"2026050209114581000_xuag019-B2","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1080\/13506129.2021.1966624","article-title":"Patients with cardiac amyloidosis have a greater neurohormonal activation than those with non-amyloidotic heart failure","volume":"28","author":"Vergaro","year":"2021","journal-title":"Amyloid"},{"key":"2026050209114581000_xuag019-B3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/eurheartj\/ehaf710","article-title":"Non-amyloid specific treatment for transthyretin cardiac amyloidosis: a clinical consensus statement of the ESC Heart Failure Association","volume":"47","author":"Garcia-Pavia","year":"2026","journal-title":"Eur Heart J"},{"key":"2026050209114581000_xuag019-B4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejim.2020.05.015","article-title":"Safety and tolerability of neurohormonal antagonism in cardiac amyloidosis","volume":"80","author":"Aimo","year":"2020","journal-title":"Eur J Intern Med"},{"key":"2026050209114581000_xuag019-B5","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1056\/NEJMoa2107038","article-title":"Empagliflozin in heart failure with a preserved ejection fraction","volume":"385","author":"Anker","year":"2021","journal-title":"N Engl J Med"},{"key":"2026050209114581000_xuag019-B6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/00952990903005882","article-title":"Employing complier average causal effect analytic methods to examine effects of randomized encouragement trials","volume":"35","author":"Connell","year":"2009","journal-title":"Am J Drug Alcohol Abuse"},{"key":"2026050209114581000_xuag019-B7","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.2214\/ajr.19.21511","article-title":"Randomized clinical trial of a clinical decision support tool for improving the appropriateness scores for ordering imaging studies in primary and specialty care ambulatory clinics","volume":"213","author":"Palen","year":"2019","journal-title":"Am J Roentgenol"},{"key":"2026050209114581000_xuag019-B8","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1093\/aje\/kwv254","article-title":"Using big data to emulate a target trial when a randomized trial is not available","volume":"183","author":"Hern\u00e1n","year":"2016","journal-title":"Am J Epidemiol"},{"key":"2026050209114581000_xuag019-B9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/pds.5587","article-title":"Federated analyses of multiple data sources in drug safety studies","volume":"32","author":"Gedeborg","year":"2023","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2026050209114581000_xuag019-B10","doi-asserted-by":"publisher","first-page":"100864","DOI":"10.1016\/j.landig.2025.02.004","article-title":"Medical digital twins: enabling precision medicine and medical artificial intelligence","volume":"7","author":"Sad\u00e9e","year":"2025","journal-title":"Lancet Digit Health"},{"key":"2026050209114581000_xuag019-B11","doi-asserted-by":"publisher","first-page":"100851","DOI":"10.1016\/j.landig.2025.01.007","article-title":"Digital twins, synthetic patient data, and in-silico trials: can they empower paediatric clinical trials?","volume":"7","author":"Pammi","year":"2025","journal-title":"Lancet Digit Health"},{"key":"2026050209114581000_xuag019-B12","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1056\/NEJMoa1308789","article-title":"Thrombus aspiration during ST-segment elevation myocardial infarction","volume":"369","author":"Fr\u00f6bert","year":"2013","journal-title":"N Engl J Med"},{"key":"2026050209114581000_xuag019-B13","doi-asserted-by":"publisher","first-page":"e0277409","DOI":"10.1371\/journal.pone.0277409","article-title":"A pragmatic parallel arm randomized-controlled trial of a multi-pronged electronic health record-based clinical decision support tool protocol to reduce low-value antipsychotic prescriptions among older adults with Alzheimer's and related dementias","volume":"17","author":"Mafi","year":"2022","journal-title":"PLoS One"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article-pdf\/doi\/10.1093\/ejhf\/xuag019\/66503480\/xuag019.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/28\/1\/108\/66503480\/xuag019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/article-pdf\/28\/1\/108\/66503480\/xuag019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:11:56Z","timestamp":1777727516000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/article\/28\/1\/108\/8434490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,21]]},"published-print":{"date-parts":[[2026,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ejhf\/xuag019","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]}}}