{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:15:52Z","timestamp":1791875752101,"version":"4.3.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270400"],"award-info":[{"award-number":["82270400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570457"],"award-info":[{"award-number":["82570457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010731"],"award-info":[{"award-number":["2023A1515010731"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM2024110210"],"award-info":[{"award-number":["SZSM2024110210"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The natural history of hepatic involvement in tricuspid regurgitation (TR) remains undercharacterized. We aimed to assess the incidence and risk of liver-related outcomes associated with TR severity and to identify the predictors and survival impact of cirrhosis in patients with \u2265moderate TR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2004 to 2022, adults with documented TR severity were retrospectively included. Liver-related outcomes including cirrhosis, hepatocellular carcinoma (HCC), and liver-related death were followed longitudinally.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 41 950 patients without prevalent liver disease, 7226 (17.3%) had \u2265moderate TR. The median follow-up was 6.4 years. Incidence rates of cirrhosis, HCC and liver-related death in patients with \u2265moderate TR were 4.54 [95% confidence interval (CI), 3.89\u20135.29], 1.25 (95% CI, 0.92\u20131.68), and 1.33 (95% CI, 0.99\u20131.77) per 1000 person-years, respectively. Compared with no\/trace TR, both moderate and severe TR were associated with an increased risk of cirrhosis, while risks of HCC and liver-related death did not differ statistically across TR severity groups. Among patients with \u2265moderate TR, independent predictors of cirrhosis were heart failure with preserved ejection fraction, right ventricular dysfunction, and cholestatic liver injury. Ventricular TR [hazard ratio (HR): 2.33, 95% CI, 1.22\u20134.43, P = .009] and lead-associated TR (HR: 2.66, 95% CI, 1.16\u20136.09, P = .02) were associated with a higher risk of cirrhosis than atrial TR. Incident cirrhosis increased all-cause and cardiovascular death risks in patients with \u2265moderate TR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Significant TR is associated with incident cirrhosis, with risk varying by aetiology. The development of cirrhosis portends a worse survival, supporting more comprehensive hepatic evaluation during TR management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag057","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:41:51Z","timestamp":1773924111000},"source":"Crossref","is-referenced-by-count":2,"title":["Liver-related outcomes in patients with tricuspid regurgitation"],"prefix":"10.1093","author":[{"given":"Jingnan","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, The University of Hong Kong-Shenzhen Hospital , 1 Haiyuan 1 Rd, Shenzhen 518009 ,","place":["China"]},{"name":"Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital , Pok Fu Lam Rd, Hong Kong SAR 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