{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:58:37Z","timestamp":1785851917070,"version":"3.56.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundry Innovation and Research 1, Ireland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Congestion signals heart failure (HF) progression and drives decompensation. Reliable management strategies remain poorly developed. We evaluated 12 months of congestion-guided clinical management following implantation of an inferior vena cava (IVC) sensor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Data were combined from two prospective studies (FUTURE-HF and FUTURE-HFII) (N =65, mean age 65.7 \u00b1 9.5 years; 75.4% NYHA III; 90.8% heart failure with reduced ejection fraction. Patients recorded daily IVC parameters. Adjudicated safety outcomes, sensor-derived IVC area measurement versus CT imaging, medication adjustments, and clinical outcomes at 12 months were analysed.<\/jats:p>\n                    <jats:p>No adjudicated device or procedure-related serious adverse events occurred. Excellent correlation was observed between sensor-derived and CT-derived IVC area (n = 44; R2 = 0.97; mean relative error &amp;lt;5%). Patient adherence was 93%, and a sustained, significant reduction in IVC area was observed (8.1%, P &amp;lt; .005), correlated with clinical improvements (P &amp;lt; .001), despite no significant change in body weight. Improvements were observed in the New York Heart Association (NYHA) functional class (Class III: 74.5% improved to 40.0%; P &amp;lt; .01) and N-terminal pro-B-type natriuretic peptide (median 1697 reduced to 998\u2005ng\/L; P &amp;lt; .001). HF events (HFEs) were lower post-implant (0.31\/year, 1.67\/year pre-implant; 84.5% relative reduction; rate ratio: 0.18; 95% CI: 0.08\u20130.29). Medication adjustments (n = 415) included diuretic titration (57%) and increased use of guideline directed medical therapy from baseline to 12-months (28%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Congestion management through ambulatory IVC monitoring demonstrated excellent safety, sustained accuracy, and high levels of patient adherence at 12-months after sensor implantation. This was associated with improved HF congestion status and a lower observed rate of HFEs, supporting investigation of congestion-guided management using IVC monitoring in a pivotal randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag080","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:27:54Z","timestamp":1773664074000},"source":"Crossref","is-referenced-by-count":2,"title":["Long-term safety and performance of an implantable IVC sensor for congestion-guided management in heart failure: 12-month results from the FUTURE-HF trial portfolio"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-2228","authenticated-orcid":false,"given":"Kevin","family":"Damman","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Center Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2301-3587","authenticated-orcid":false,"given":"Nir","family":"Uriel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center , NewYork, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep R","family":"Mehra","sequence":"additional","affiliation":[{"name":"Center for Advanced Heart Disease, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Testani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Duke University Medical Center , Division of Cardiology, Department of Medicine, Durham, NC ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunjan","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Heart Failure, Austin Heart Hospital , Austin, TX ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-2909","authenticated-orcid":false,"given":"Rami","family":"Kahwash","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trejeeve","family":"Martyn","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute, Cleveland Clinic , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-6546","authenticated-orcid":false,"given":"Scott","family":"Feitell","sequence":"additional","affiliation":[{"name":"Rochester Regional Health, Sands-Constellation Heart Institute , Rochester, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Khabeishvili","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Clinic Healthicore , Tbilisi ,","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-8165","authenticated-orcid":false,"given":"Petr","family":"Neuzil","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Na Homolce Hospital , Prague ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Sayer","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center , NewYork, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irakli","family":"Gogorishvili","sequence":"additional","affiliation":[{"name":"Tbilisi Heart and Vascular Clinic, Ilia State University , Tbilisi ,","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Critoph","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals Dorset NHS Foundation Trust , Bournemouth ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Galway , Galway ,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Loke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Southampton NHS Foundation Trust , Southampton ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy S","family":"Gardner","sequence":"additional","affiliation":[{"name":"Scottish National Advanced Heart Failure Service, Golden Jubilee National Hospital , Clydebank ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ondrej","family":"Toman","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, University Hospital Brno , Brno ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Flett","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5522-9318","authenticated-orcid":false,"given":"Jasper J","family":"Brugts","sequence":"additional","affiliation":[{"name":"Erasmus MC University Medical Centre, Cardiovascular Institute , Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Vazir","sequence":"additional","affiliation":[{"name":"Royal Brompton Hospital, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Buxo","sequence":"additional","affiliation":[{"name":"Foundry Innovation & 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