{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:28:30Z","timestamp":1781335710283,"version":"3.54.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Current cardiogenic shock (CS) management primarily targets mean arterial pressure (MAP), often overlooking the impact of venous congestion on the effective perfusion gradient. Organ perfusion pressure (OPP = MAP \u2013 CVP) integrates both. We investigated OPP\u2019s prognostic value for mortality, renal function, and resource utilization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study utilized Medical Information Mart for Intensive Care (MIMIC-IV) database, a single-center, critical care database, to identify adult CS patients. Patients with other forms of shock were excluded. Primary outcomes were in-hospital and intensive care unit (ICU) mortality. Secondary outcomes included ICU length of stay (LOS), vasopressors\/inotropes duration (VID), urine output (UO) over the initial 36\u2005hours, renal replacement therapy (RRT) and invasive mechanical ventilation. Multivariable models adjusted for demographics (age, sex), comorbidities (hypertension, diabetes, heart failure, atrial fibrillation, chronic kidney disease), and shock severity (cardiac arrest, vasoactive-inotropic score, maximum lactate) across standardized 12-hour landmarks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 189 patients (mean age 65.3 \u00b1 14.2 years, 65.6% male), prevalent comorbidities included coronary artery disease (52.4%) and heart failure with reduced ejection fraction (50.8%). Acute myocardial infarction was present in 26.5% of cases. Every 5\u2005mmHg increase in 24-hour mean OPP was independently associated with reduced in hospital mortality (adjusted odds ratios [aOR] 0.79, 95% CI 0.65\u20130.96, P = .020). Higher OPP was associated with renal protection, with increased UO (+0.21\u2005mL\/kg\/hr, P &amp;lt; 0.001) and reduced odds of RRT (aOR 0.65, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CS, a higher OPP is independently associated with improved survival, renal preservation, and resource efficiency. OPP provided incremental value especially for renal outcomes. Prospective interventional trials are mandatory for validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag149","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:25:04Z","timestamp":1777724704000},"source":"Crossref","is-referenced-by-count":1,"title":["Organ perfusion pressure as a hemodynamic target in cardiogenic shock"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7010-9433","authenticated-orcid":false,"given":"Omar","family":"Khayat","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Staten Island University Hospital, Northwell Health , New Hyde Park, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahy","family":"Abofrekha","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Staten Island University Hospital, Northwell Health , New Hyde Park, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Andre","family":"Ehrenfels","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Staten Island University Hospital, Northwell Health , New Hyde Park, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Staten Island University Hospital, Northwell Health , New Hyde Park, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A","family":"Zayed","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Staten Island University Hospital, Northwell Health , New Hyde Park, NY ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Itani","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Staten Island University 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