{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:17:22Z","timestamp":1793139442626,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"am","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Netherlands Heart Foundation CVON Double Dose","award":["2020B005"],"award-info":[{"award-number":["2020B005"]}]},{"name":"Netherlands Heart Foundation CarMa","award":["01-003-2022-0358"],"award-info":[{"award-number":["01-003-2022-0358"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Hypertrophic cardiomyopathy (HCM) is characterized by increased risk of malignant ventricular arrhythmias (MVA) and heart failure (HF). There is increasing awareness that epicardial adipose tissue (EAT) is associated with an adverse prognosis in cardiovascular disease, but its role in genotype-positive HCM patients is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>EAT volume was quantified by cardiovascular magnetic resonance in a retrospective genotype-positive HCM cohort. Patients were split into high and low EAT groups by the median. Multivariable Cox regression was used to examine the association between EAT volume and (1) MVA (sustained ventricular tachycardia, ventricular fibrillation, appropriate implantable cardioverter defibrillator shock, sudden cardiac death (SCD), or death of unknown cause), and (2) HF events (HF hospitalization, heart transplantation, or HF-related mortality).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 282 patients (48 \u00b1 14 years, 64.5% male). The high EAT group had greater maximal wall thickness (25.0 \u00b1 6.4 vs 20.8 \u00b1 4.9\u2005mm, P &amp;lt; .001), more extensive late gadolinium enhancement (6.1% [0.0\u201314.0] vs 1.0% [0.0\u20136.2], P &amp;lt; .001), and more frequent left ventricular outflow tract obstruction (42.6% vs 15.6%, P &amp;lt; .001) compared with the low EAT group. During 62 [32\u201396] months of follow-up, EAT volume was independently associated with the incidence of MVA (HR 1.04 [95%CI 1.02\u20131.06], P &amp;lt; .001) and HF events (HR 1.05 [95%CI 1.03\u20131.08], P &amp;lt; .001). EAT volume showed good discriminative ability for both MVA (C-statistic 0.79, P &amp;lt; .001) and HF events (C-statistic 0.79, P &amp;lt; .001), and appeared to perform better than the HCM SCD risk score for MVA (C-statistic comparison P = .011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EAT accumulation is associated with phenotype severity and independently associated with the incidence of MVA and HF events in genotype-positive HCM patients.<\/jats:p>\n                    <jats:p>These findings suggest that EAT should be considered a novel factor in HCM risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag179","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:46:00Z","timestamp":1779363960000},"source":"Crossref","is-referenced-by-count":1,"title":["Epicardial adipose tissue is associated with impaired outcomes in genotype-positive hypertrophic cardiomyopathy"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-248X","authenticated-orcid":false,"given":"Belend","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Centre Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J","family":"Koppelaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Thorax Centre, Erasmus Medical Centre , Room Rg-419, PO Box 2040, Rotterdam, CA 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-0431","authenticated-orcid":false,"given":"Michelle","family":"Michels","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Thorax Centre, Erasmus Medical Centre , Room Rg-419, PO Box 2040, Rotterdam, CA 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2825-8428","authenticated-orcid":false,"given":"Moniek G P J","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Centre Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-016X","authenticated-orcid":false,"given":"Stephan A C","family":"Schoonvelde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Thorax Centre, Erasmus Medical Centre , Room Rg-419, PO Box 2040, Rotterdam, CA 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M A","family":"Verhagen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Erasmus Medical Centre , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo P J","family":"Budde","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Erasmus Medical Centre , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4775-9140","authenticated-orcid":false,"given":"Rudolf A","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Thorax Centre, Erasmus Medical Centre , Room Rg-419, PO Box 2040, Rotterdam, CA 3000 ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-7019","authenticated-orcid":false,"given":"Berend Daan","family":"Westenbrink","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Groningen, University Medical Centre Groningen , Groningen ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3315-2006","authenticated-orcid":false,"given":"Alexander","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiovascular Institute, Thorax Centre, Erasmus Medical Centre , Room Rg-419, PO Box 2040, Rotterdam, CA 3000 ,","place":["The Netherlands"]},{"name":"Department of Radiology and Nuclear Medicine, Erasmus Medical Centre , Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"2026060814284818600_xuag179-B1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1161\/01.CIR.92.4.785","article-title":"Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA 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