{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:56:30Z","timestamp":1781110590127,"version":"3.54.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01702"],"award-info":[{"award-number":["PI20\/01702"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019179","name":"Obra Social \u2018La Caixa Foundation\u2019","doi-asserted-by":"publisher","award":["ID100010434"],"award-info":[{"award-number":["ID100010434"]}],"id":[{"id":"10.13039\/501100019179","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria FIS","award":["PI17\/01690"],"award-info":[{"award-number":["PI17\/01690"]}]},{"name":"Instituto Salud Carlos III"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Arrhythmia-induced cardiomyopathy develops unpredictably in a subset of patients with atrial fibrillation, with marked interindividual variability in severity and recurrence risk. Whether genetic susceptibility contributes to this heterogeneity remains uncertain. We aimed to determine the prevalence and clinical impact of deleterious variants in cardiomyopathy-associated genes among patients with arrhythmia-induced cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective, multicentre study, patients with arrhythmia-induced cardiomyopathy underwent genetic testing targeting cardiomyopathy-associated genes. Individuals carrying pathogenic or likely pathogenic variants were classified as genotype-positive. Baseline characteristics, clinical severity and follow-up outcomes were compared between genotype-positive and genotype-negative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 100 patients (mean age 59.9 \u00b1 11.1 years, 18% women, baseline left ventricular ejection fraction 28.2 \u00b1 7.3%), 16 (16%) were genotype-positive, with TTN truncating variants accounting for 75% of variants. Compared with genotype-negative individuals, genotype-positive patients more frequently had a family history of cardiomyopathy (31.2% vs 4.8%, P = .005) and sudden death (25% vs 6%, P = .034), presented with more severe disease -including lower ejection fraction (24.6% vs 28.8%, P = .034) and higher incidence of cardiogenic shock (25% vs 3.6%, P = .012)- and exhibited a higher risk of recurrence (18.8% vs 2.4%, P = .028).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Arrhythmia-induced cardiomyopathy patients exhibit a substantial prevalence of deleterious variants in cardiomyopathy-associated genes, particularly TTN truncating variants. Genotype-positive individuals represent a high-risk subgroup with greater familial burden, more severe clinical presentation and increased recurrence risk. Genetic testing may identify at-risk patients, refine prognostic stratification and guide therapy and follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag181","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:45:38Z","timestamp":1779450338000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic determinants of severity and recurrence in arrhythmia-induced cardiomyopathy"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-5907","authenticated-orcid":false,"given":"Coloma","family":"Tiron","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitari Dr. Josep Trueta , Avinguda de Fran\u00e7a s\/n, 17007 Girona ,","place":["Spain"]},{"name":"Girona Biomedical Research Institute (IDIBGI) , Parc Hospitalari Mart\u00ed i Juli\u00e0, Edifici M2, Carrer del Dr Castany s\/n, 17190 Salt (Girona) ,","place":["Spain"]},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Calle de Melchor Fern\u00e1ndez Almagro, 3, Fuencarral-El Pardo, 28029 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Soriano-Amores","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Calle de Melchor Fern\u00e1ndez Almagro, 3, Fuencarral-El Pardo, 28029 Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Sant Pau (IR Sant Pau), Universitat Aut\u00f2noma de Barcelona , Barcelona \u00a0","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Ramos-Polo","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) , Calle de Melchor Fern\u00e1ndez Almagro, 3, Fuencarral-El 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