{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:05:16Z","timestamp":1788307516027,"version":"build-2803163510"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Erich & Hanna Klessmann-Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Severe cardiomyopathies in children may often demand treatment with inclusion of mechanical circulatory support (MCS) or heart transplantation (HTx). Although these cardiomyopathies are not always hereditary, myocarditis may be regarded as a likely cause, if the clinical course is not chronic. Aims of this study were the identification of genetic profile and prevalence of myocarditis in a paediatric population with severe cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively included 106 paediatric and adolescent cardiomyopathy (CMPY) patients requiring HTx, MCS, or any in-hospital treatment. Variants from DNA sequencing were classified according to the American College of Molecular Genetics guidelines. Myocarditis was diagnosed according to the clinical protocol. We overall genotyped 106 patients; 92 (87%) receiving HTx or MCS and 14 (13%) in hospital treatment; 87 patients (82%) had dilated cardiomyopathy; and 54 (51%) carried a (likely) pathogenic (P\/LP) variant with TNNI3 as one of the leading affected genes. In 84 genotyped patients (80%), myocarditis was examined; 57 (68%) of the 84 had myocarditis, with chronic lymphocytic myocarditis in 34 (40%) cases. In 28 (49%) of 57 patients with and 14 (52%) of 27 patients without myocarditis P\/LP variants were found. In 41 cases (39%) genotyping of the parents suggests de novo P\/LP variants (34%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In severe CMPY, genetic causes and myocarditis are common. About 50% of childhood cardiomyopathies are linked to P\/LP variants. Myocarditis signatures are not necessarily specific and cannot be suggested as the only reason for early heart failure. Genotyping in severe CMPY is essential to identify the causes of myocarditis. Providing genetic counselling may support families facing challenging psychosocial situations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag214","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:47:34Z","timestamp":1782992854000},"source":"Crossref","is-referenced-by-count":1,"title":["A high proportion of children with severe cardiomyopathies show both myocarditis and genetic predispositions"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-0007","authenticated-orcid":false,"given":"Hendrik","family":"Milting","sequence":"first","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, University Hospital, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-7693","authenticated-orcid":false,"given":"Anna","family":"G\u00e4rtner","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, University Hospital, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, University Hospital, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Manuylova","sequence":"additional","affiliation":[{"name":"Cardiopathology, Institute of Pathology and Neuropathology, University Hospital T\u00fcbingen , Liebermeisterstr. 8, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-2498","authenticated-orcid":false,"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[{"name":"Cardiopathology, Institute of Pathology and Neuropathology, University Hospital T\u00fcbingen , Liebermeisterstr. 8, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Habich","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, University Hospital, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hitz","sequence":"additional","affiliation":[{"name":"Institute for Medical Genetics , University Hospital Oldenburg, Carl von Ossietzky University Oldenburg, Rahel Strauss Str. 10, 26133 Oldenburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Tiesmeier","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, University Hospital, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Valesca","family":"Laser","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, University Hospital, Erich and Hanna Klessmann-Institute for Cardiovascular Research and Development , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edzard","family":"zu Knyphausen","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, Center of Congenital Heart Diseases , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yusenko","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Human Genetics, Ruhr-University Bochum , Universit\u00e4tsstr. 150, 44780 Bochum ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoa Huu Phuc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Human Genetics, Ruhr-University Bochum , Universit\u00e4tsstr. 150, 44780 Bochum ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Foth","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, Center of Congenital Heart Diseases , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5816-863X","authenticated-orcid":false,"given":"Eugen","family":"Sandica","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, Center of Congenital Heart Diseases , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-6490","authenticated-orcid":false,"given":"Stephan","family":"Schubert","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, Center of Congenital Heart Diseases , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Laser","sequence":"additional","affiliation":[{"name":"Ruhr-University Bochum, Heart and Diabetescenter NRW, Center of Congenital Heart Diseases , Georgstr. 11, 32545 Bad Oeynhausen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"2026083021363086100_xuag214-B1","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1097\/INF.0000000000004678","article-title":"Diagnosis and management of pediatric myocarditis","volume":"44","author":"Werner","year":"2025","journal-title":"Pediatr Infect Dis J"},{"key":"2026083021363086100_xuag214-B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13690-024-01473-4","article-title":"Global burden and attributable risk factors of inflammatory cardiomyopathy and myocarditis from 1990 to 2019","volume":"83","author":"Wu","year":"2025","journal-title":"Arch Public Health"},{"key":"2026083021363086100_xuag214-B3","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017731","article-title":"Genetic causes of cardiomyopathy in children: first results from the pediatric cardiomyopathy genes study","volume":"10","author":"Ware","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026083021363086100_xuag214-B4","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1002\/ehf2.12686","article-title":"Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies","volume":"7","author":"Piriou","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2026083021363086100_xuag214-B5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022854","article-title":"Genotype and cardiac outcomes in pediatric dilated cardiomyopathy","volume":"11","author":"Khan","year":"2022","journal-title":"J Am Heart Assoc"},{"key":"2026083021363086100_xuag214-B6","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1093\/eurheartj\/ehae109","article-title":"Cardiomyopathies in children and adolescents: aetiology, management, and outcomes in the European Society of Cardiology EURObservational Research Programme Cardiomyopathy and Myocarditis Registry","volume":"45","author":"Kaski","year":"2024","journal-title":"Eur Heart J"},{"key":"2026083021363086100_xuag214-B7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00246-019-02240-x","article-title":"Identification of gene mutations in primary pediatric cardiomyopathy by whole exome sequencing","volume":"41","author":"Rojnueangnit","year":"2020","journal-title":"Pediatr Cardiol"},{"key":"2026083021363086100_xuag214-B8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s40291-022-00604-3","article-title":"Molecular diagnosis of primary cardiomyopathy in 231 unrelated pediatric cases by panel-based next-generation sequencing: a major focus on five carriers of biallelic TNNI3 pathogenic variants","volume":"26","author":"Janin","year":"2022","journal-title":"Mol Diagn Ther"},{"key":"2026083021363086100_xuag214-B9","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1161\/CIRCGEN.120.002969","article-title":"Categorized genetic analysis in childhood-onset cardiomyopathy","volume":"13","author":"Al-Hassnan","year":"2020","journal-title":"Circ Genom Precis Med"},{"key":"2026083021363086100_xuag214-B10","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.jchf.2022.06.013","article-title":"Acute myocarditis associated with desmosomal gene variants","volume":"10","author":"Ammirati","year":"2022","journal-title":"JACC Heart Fail"},{"key":"2026083021363086100_xuag214-B11","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.jacbts.2021.06.001","article-title":"Myopathic cardiac genotypes increase risk for myocarditis","volume":"6","author":"Kontorovich","year":"2021","journal-title":"JACC Basic Transl Sci"},{"key":"2026083021363086100_xuag214-B12","doi-asserted-by":"publisher","DOI":"10.1161\/circgen.121.003426","article-title":"Burden of cardiomyopathic genetic variation in lethal pediatric myocarditis","volume":"14","author":"Kontorovich","year":"2021","journal-title":"Circ Genom Precis Med"},{"key":"2026083021363086100_xuag214-B13","doi-asserted-by":"publisher","first-page":"216","DOI":"10.3390\/jcdd9070216","article-title":"Pathogenic variants in cardiomyopathy disorder genes underlie pediatric myocarditis-further impact of heterozygous immune disorder gene variants?","volume":"9","author":"Seidel","year":"2022","journal-title":"J Cardiovasc Dev Dis"},{"key":"2026083021363086100_xuag214-B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.120.003250","article-title":"Pathogenic variants associated with dilated cardiomyopathy predict outcome in pediatric myocarditis","volume":"14","author":"Seidel","year":"2021","journal-title":"Circ Genom Precis Med"},{"key":"2026083021363086100_xuag214-B15","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/ejhg.2014.211","article-title":"Compound heterozygous or homozygous truncating MYBPC3 mutations cause lethal cardiomyopathy with features of noncompaction and septal defects","volume":"23","author":"Wessels","year":"2015","journal-title":"Eur J Hum Genet"},{"key":"2026083021363086100_xuag214-B16","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1016\/s0195-668x(03)00466-4","article-title":"The 2373insG mutation in the MYBPC3 gene is a founder mutation, which accounts for nearly one-fourth of the HCM cases in The Netherlands","volume":"24","author":"Alders","year":"2003","journal-title":"Eur Heart J"},{"key":"2026083021363086100_xuag214-B17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.resuscitation.2021.07.042","article-title":"The emergency medical service has a crucial role to unravel the genetics of sudden cardiac arrest in young, out of hospital resuscitated patients: interim data from the MAP-IT study","volume":"168","author":"Tiesmeier","year":"2021","journal-title":"Resuscitation"},{"key":"2026083021363086100_xuag214-B18","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1093\/eurheartj\/ehq101","article-title":"Early identification of mutation carriers in familial hypertrophic cardiomyopathy by combined echocardiography and tissue Doppler imaging","volume":"31","author":"Gandjbakhch","year":"2010","journal-title":"Eur Heart J"},{"key":"2026083021363086100_xuag214-B19","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/jmedgenet-2012-101270","article-title":"Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing","volume":"50","author":"Lopes","year":"2013","journal-title":"J Med Genet"},{"key":"2026083021363086100_xuag214-B20","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1161\/01.CIR.0000066323.15244.54","article-title":"Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy","volume":"107","author":"Richard","year":"2003","journal-title":"Circulation"},{"key":"2026083021363086100_xuag214-B21","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"2026083021363086100_xuag214-B22","doi-asserted-by":"publisher","first-page":"9625","DOI":"10.3390\/ijms22179625","article-title":"De novo missense mutations in TNNC1 and TNNI3 causing severe infantile cardiomyopathy affect myofilament structure and function and are modulated by troponin targeting agents","volume":"22","author":"Hassoun","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026083021363086100_xuag214-B23","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ymgme.2004.04.013","article-title":"Novel troponin T mutation in familial dilated cardiomyopathy with gender-dependant severity","volume":"83","author":"Stefanelli","year":"2004","journal-title":"Mol Genet Metab"},{"key":"2026083021363086100_xuag214-B24","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.787581","article-title":"Mechanisms of arrhythmogenicity of hypertrophic cardiomyopathy-associated troponin T (TNNT2) variant I79N","volume":"9","author":"Shafaattalab","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026083021363086100_xuag214-B25","doi-asserted-by":"publisher","author":"Shafaatalab","DOI":"10.1101\/2023.06.06.542948"},{"key":"2026083021363086100_xuag214-B26","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1542\/peds.2005-2301","article-title":"Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene","volume":"117","author":"Peddy","year":"2006","journal-title":"Pediatrics"},{"key":"2026083021363086100_xuag214-B27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.yrtph.2013.09.008","article-title":"Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review","volume":"69","author":"Cohen Hubal","year":"2014","journal-title":"Regul Toxicol Pharmacol"},{"key":"2026083021363086100_xuag214-B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2025.102854","article-title":"Severe myocarditis increase in children associated with parvovirus B19 infection: MYKKE registry and German surveillance data","volume":"14","author":"Seidel","year":"2026","journal-title":"JACC Heart Fail"},{"key":"2026083021363086100_xuag214-B29","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases","volume":"34","author":"Caforio","year":"2013","journal-title":"Eur Heart J"},{"key":"2026083021363086100_xuag214-B30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1001\/jama.2024.21972","article-title":"World medical association declaration of Helsinki: ethical principles for medical research involving human participants","volume-title":"JAMA","author":"World Medical A","year":"2025"},{"key":"2026083021363086100_xuag214-B31","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/bioe.13270","article-title":"The Declaration of Helsinki in bioethics literature since the last revision in 2013","volume":"38","author":"Ehni","year":"2024","journal-title":"Bioethics"},{"key":"2026083021363086100_xuag214-B32","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"2026083021363086100_xuag214-B33","volume-title":"ACGS Best Practice Guidelines for Variant Classification in Rare Disease","author":"Durkie","year":"2024"},{"key":"2026083021363086100_xuag214-B34","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/humu.24088","article-title":"Fitting a naturally scaled point system to the ACMG\/AMP variant classification guidelines","volume":"41","author":"Tavtigian","year":"2020","journal-title":"Hum Mutat"},{"key":"2026083021363086100_xuag214-B35","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/joim.13351","article-title":"The frequency of misattributed paternity in Sweden is low and decreasing: a nationwide cohort study","volume":"291","author":"Dahlen","year":"2022","journal-title":"J Intern Med"},{"key":"2026083021363086100_xuag214-B36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/joim.13357","article-title":"Mommy\u2019s baby, daddy\u2019s maybe: misattributed paternity in a nationwide blood group database","volume":"291","author":"Larmuseau","year":"2022","journal-title":"J Intern Med"},{"key":"2026083021363086100_xuag214-B37","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.tree.2016.03.004","article-title":"Cuckolded fathers rare in human populations","volume":"31","author":"Larmuseau","year":"2016","journal-title":"Trends Ecol Evol"},{"key":"2026083021363086100_xuag214-B38"},{"key":"2026083021363086100_xuag214-B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2022.107492","article-title":"Myocarditis and endomyocardial biopsy: achieving consensus diagnosis on 100 cases","volume":"62","author":"Lu","year":"2023","journal-title":"Cardiovasc Pathol"},{"key":"2026083021363086100_xuag214-B40","author":"R-Development-Core-Team"},{"key":"2026083021363086100_xuag214-B41","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-22593-6","volume-title":"Verteilungsfreie Methoden in der Biostatistik","author":"Bortz","year":"1990"},{"key":"2026083021363086100_xuag214-B42","volume-title":"Categorial Data Analysis","author":"Agresti","year":"2007"},{"key":"2026083021363086100_xuag214-B43","volume-title":"Nonparametrics\u2014Statistical Methods Based on Ranks","author":"Lehmann","year":"1998"},{"key":"2026083021363086100_xuag214-B44","volume-title":"Analysis of Survival Data","author":"Cox","year":"1984"},{"key":"2026083021363086100_xuag214-B45","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2307\/2281868","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Soc"},{"key":"2026083021363086100_xuag214-B46","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/eurheartj\/ehad194","article-title":"2023 ESC guidelines for the management of cardiomyopathies","volume":"44","author":"Arbelo","year":"2023","journal-title":"Eur Heart J"},{"key":"2026083021363086100_xuag214-B47","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003686","article-title":"Genetic basis of childhood cardiomyopathy","volume":"15","author":"Bagnall","year":"2022","journal-title":"Circ Genom Precis Med"},{"key":"2026083021363086100_xuag214-B48","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1016\/j.jacc.2018.08.2171","article-title":"Genetic basis of severe childhood-onset cardiomyopathies","volume":"72","author":"Vasilescu","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026083021363086100_xuag214-B49","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.jacc.2025.04.068","article-title":"Sex differences in the genetic causes of dilated cardiomyopathy","volume":"86","author":"Mangino","year":"2025","journal-title":"J Am Coll Cardiol"},{"key":"2026083021363086100_xuag214-B50","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.cjca.2020.11.014","article-title":"How diabetes and heart failure modulate each other and condition management","volume":"37","author":"Randhawa","year":"2021","journal-title":"Can J Cardiol"},{"key":"2026083021363086100_xuag214-B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262010130","article-title":"Drug repositioning in doxorubicin-induced cardiotoxicity protection","volume":"26","author":"Kosic","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026083021363086100_xuag214-B52","doi-asserted-by":"publisher","first-page":"6685","DOI":"10.3390\/ijms23126685","article-title":"Compound heterozygous FKTN variants in a patient with dilated cardiomyopathy led to an aberrant alpha-dystroglycan pattern","volume":"23","author":"Gaertner","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026083021363086100_xuag214-B53","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00439-015-1627-5","article-title":"Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations","volume":"135","author":"Yaoita","year":"2016","journal-title":"Hum Genet"},{"key":"2026083021363086100_xuag214-B54","author":"NCBI"},{"key":"2026083021363086100_xuag214-B55","doi-asserted-by":"publisher","first-page":"185","DOI":"10.31083\/j.rcm2306185","article-title":"Genotype-phenotype associations with restrictive cardiomyopathy induced by pathogenic genetic mutations","volume":"23","author":"Yang","year":"2022","journal-title":"Rev Cardiovasc Med"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article-pdf\/doi\/10.1093\/ejhf\/xuag214\/68693452\/xuag214.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article-pdf\/doi\/10.1093\/ejhf\/xuag214\/68693452\/xuag214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:36:40Z","timestamp":1788140200000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article\/doi\/10.1093\/ejhf\/xuag214\/8724412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,3]]},"references-count":55,"URL":"https:\/\/doi.org\/10.1093\/ejhf\/xuag214","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,3]]},"article-number":"xuag214"}}