{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:57:20Z","timestamp":1786118240774,"version":"build-2736575974"},"reference-count":235,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heart failure (HF) and chronic liver disease account for substantial morbidity and mortality worldwide. Both conditions share common risk factors and a bidirectional pathophysiology, and the coexistence of both conditions is expected to increase over time. Management of coexisting HF and liver disease is challenged by the under-representation of participants with liver disease in landmark HF clinical trials, impaired haemodynamics at advanced stages of liver disease, altered drug metabolism, and higher risk of adverse events than portended by either condition alone. Moreover, diagnostic pitfalls might be encountered in relation to assessing the primary aetiologies driving the disease process, estimating the degree of liver fibrosis, and differentiating primary liver disease from HF-related liver congestion particularly, given the complex interplay between sinusoidal pressure, congestion, and structural fibrosis. Cardiovascular-hepatic cross-thematic research, clinical education, and health care services could optimize management and patient outcomes. The purpose of the current review is to (i) highlight the growing epidemiology of concurrent HF-liver disease; (ii) provide diagnostic clues for liver disease and an approach for interpreting liver marker abnormalities amongst HF patients; (iii) describe the main therapeutic strategies in real-world clinical settings; and (iv) discuss current gaps in knowledge and future directions. This update on the framework of the HF-liver disease overlap phenomenon can inform clinical care policies and facilitate novel research in the field.<\/jats:p>","DOI":"10.1093\/ejhf\/xuag243","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:18:53Z","timestamp":1785323933000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation and management of heart failure patients with liver disease: European Journal of Heart Failure international expert position paper"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-0660","authenticated-orcid":false,"given":"Anzhela","family":"Soloveva","sequence":"first","affiliation":[{"name":"Hospital Therapy Department \u21162, I.M. Sechenov First Moscow State Medical University , 2-4 Bolshaya Pirogovskay, Moscow 119435 ,","place":["Russian Federation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University School of Medicine , Seongnam ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios A","family":"Apostolou","sequence":"additional","affiliation":[{"name":"Department of Medicine, National and Kapodistrian University of Athens , Athens ,","place":["Greece"]},{"name":"Medical Technology Research Group and Department of Health Policy, LSE Health, London School of Economics and Political Science , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-2514","authenticated-orcid":false,"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology and Intensive Care Medicine), Saarland University Medical Center , Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7609-6297","authenticated-orcid":false,"given":"Antonio","family":"Cannata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King\u2019s College Hospital and School of Cardiovascular Medicine and Sciences, King\u2019s College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke University Medical Center , Durham, NC 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M","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Division of Gastroenterology, Hepatology, Endocrinology and Nutritional Medicine, Saarland University Medical Center , Homburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzhan","family":"Suleimenov","sequence":"additional","affiliation":[{"name":"Almaty Regional Health Department , Almaty Region ,","place":["Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I","family":"Tarasova","sequence":"additional","affiliation":[{"name":"Peoples\u2019 Friendship University of Russia Named After Patrice Lumumba, Department of Hospital Therapy with Courses in Endocrinology, Hematology, and Clinical Laboratory Diagnostics , Moscow ,","place":["Russian Federation"]},{"name":"RUDN University Center for the Study of the Liver , Moscow ,","place":["Russian Federation"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Naung","family":"Tun","sequence":"additional","affiliation":[{"name":"Geisel School of Medicine, Dartmouth College , Hanover, NH, USA"},{"name":"Department of Medical Sciences, Bouve College of Health Sciences, Northeastern University , Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-4569","authenticated-orcid":false,"given":"Harriette G C","family":"Van Spall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Health Sciences, McMaster University, and Population Health Research Institute , Hamilton, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H L","family":"Wu","sequence":"additional","affiliation":[{"name":"Renal Research, Kolling Institute of Medical Research, Royal North Shore Hospital and The University of Sydney , Sydney 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