{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:25:29Z","timestamp":1787297129466,"version":"build-2736575974"},"reference-count":16,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/ejhf\/xuag247","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:51:17Z","timestamp":1786189877000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond sex differences: exercise training in HFpEF as treatment of a multisystem syndrome"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-962X","authenticated-orcid":false,"given":"Amina","family":"Rakisheva","sequence":"first","affiliation":[{"name":"Faculty of Medicine of the UIB , Abay ave 8A, Almaty 050000 ,","place":["Kazakhstan"]},{"name":"Boralday Regional Hospital , Azerbayev street 1a, Almaty Region 040000 ,","place":["Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-6444","authenticated-orcid":false,"given":"Birgit","family":"Assmus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Angiology and Intensive Care Medicine, Justus-Liebig-University , Giessen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026082103110991000_xuag247-B1","doi-asserted-by":"publisher","DOI":"10.1093\/ejhf\/xuag240","article-title":"Sex differences in exercise training response among HFpEF patients: pooled analysis of OptimEx-clin and ex-DHF-trials","author":"Fegers-Wustrow","year":"2026","journal-title":"Eur J Heart Fail"},{"key":"2026082103110991000_xuag247-B2","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1001\/jama.2020.26812","article-title":"Effect of high-intensity interval training, moderate continuous training, or guideline-based physical activity advice on peak oxygen consumption in patients with heart failure with preserved ejection fraction: a randomized clinical trial","volume":"325","author":"Mueller","year":"2021","journal-title":"JAMA"},{"key":"2026082103110991000_xuag247-B3","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41591-024-03342-7","article-title":"Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial","volume":"31","author":"Edelmann","year":"2025","journal-title":"Nat Med"},{"key":"2026082103110991000_xuag247-B4","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/eurjpc\/zwaf628","article-title":"Effect of structured exercise training on chronotropic incompetence in patients with heart failure with preserved ejection fraction","volume":"33","author":"Nasser","year":"2026","journal-title":"Eur J Prev Cardiol"},{"key":"2026082103110991000_xuag247-B5","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1002\/ehf2.15225","article-title":"Training-induced change of diastolic function in heart failure with preserved ejection fraction","volume":"12","author":"Gevaert","year":"2025","journal-title":"ESC Heart Fail"},{"key":"2026082103110991000_xuag247-B6","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1007\/s10741-025-10526-x","article-title":"Aerobic, resistance, and specialized exercise training in heart failure with preserved ejection fraction: a state-of-the-art review","volume":"30","author":"Mirzai","year":"2025","journal-title":"Heart Fail Rev"},{"key":"2026082103110991000_xuag247-B7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1152\/japplphysiol.00153.2025","article-title":"Sex-based differences in peak oxygen uptake among individuals with heart failure: systematic review and meta-analysis","volume":"139","author":"Skow","year":"2025","journal-title":"J Appl Physiol (1985)"},{"key":"2026082103110991000_xuag247-B8","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.2147\/PPA.S312200","article-title":"Burden and quality of life among female and male patients with heart failure in Europe: a real-world cross-sectional study","volume":"15","author":"Fonseca","year":"2021","journal-title":"Patient Prefer Adherence"},{"key":"2026082103110991000_xuag247-B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2025.112344","article-title":"Effects of exercise training on motivation in patients with heart failure with preserved ejection fraction: results from the randomized controlled Ex-DHF trial","volume":"196","author":"Sadlonova","year":"2025","journal-title":"J Psychosom Res"},{"key":"2026082103110991000_xuag247-B10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/eurjpc\/zwaf541","article-title":"Isometric exercise training in patients with heart failure with preserved ejection fraction: a randomized controlled study","volume":"33","author":"Edwards","year":"2026","journal-title":"Eur J Prev Cardiol"},{"key":"2026082103110991000_xuag247-B11","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/eurjpc\/zwaf641","article-title":"Unsupervised home-based isometric exercise training in heart failure with preserved ejection fraction: some notes of optimism and a word of caution","volume":"33","author":"Guazzi","year":"2026","journal-title":"Eur J Prev Cardiol"},{"key":"2026082103110991000_xuag247-B12","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1056\/NEJMoa1212914","article-title":"Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes","volume":"369","author":"Look AHEAD Research Group","year":"2013","journal-title":"N Engl J Med"},{"key":"2026082103110991000_xuag247-B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70371-0","article-title":"Adherence to long-term telemonitoring-supported physical activity in patients with chronic heart failure","volume":"14","author":"L\u00f6dding","year":"2024","journal-title":"Sci Rep"},{"key":"2026082103110991000_xuag247-B14","doi-asserted-by":"publisher","first-page":"e1077","DOI":"10.1016\/S2214-109X(18)30357-7","article-title":"Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1\u00b79 million participants","volume":"6","author":"Guthold","year":"2018","journal-title":"Lancet Glob Health"},{"key":"2026082103110991000_xuag247-B15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/HCR.0000000000000629","article-title":"Underutilization of cardiac rehabilitation in women: BARRIERS AND SOLUTIONS","volume":"41","author":"Khadanga","year":"2021","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"2026082103110991000_xuag247-B16","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1177\/2047487314545279","article-title":"Cardiac rehabilitation referral, attendance and mortality in women","volume":"22","author":"Colbert","year":"2015","journal-title":"Eur J Prev Cardiol"}],"container-title":["European Journal of Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article-pdf\/doi\/10.1093\/ejhf\/xuag247\/70610957\/xuag247.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article-pdf\/doi\/10.1093\/ejhf\/xuag247\/70610957\/xuag247.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:11:11Z","timestamp":1787296271000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eurjhf\/advance-article\/doi\/10.1093\/ejhf\/xuag247\/8758920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":16,"URL":"https:\/\/doi.org\/10.1093\/ejhf\/xuag247","relation":{},"ISSN":["1388-9842","1879-0844"],"issn-type":[{"value":"1388-9842","type":"print"},{"value":"1879-0844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"article-number":"xuag247"}}