{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:08:09Z","timestamp":1788786489161,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Circadian patterns influence cardiovascular physiology, yet have not been characterized in intracardiac pressures of ambulatory chronic heart failure patients. We aimed to assess diurnal variation via a novel remote intracardiac left atrial pressure sensor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Daily ambulatory left atrial pressure (LAP) measurements were obtained with an implantable intracardiac sensor. Patients performed morning and evening measurements during longitudinal follow-up. We compared diurnal variability in morning and evening LAP, examined its potential association with diuretic regimen, presence of atrial fibrillation, and acute decompensated heart failure (ADHF) events. Across &amp;gt;15 500 measurement days with an average follow up time of 25.5 \u00b1 18.6 months in 73 heart failure patients, median left atrial pressure was higher in the evening than in the morning [12.4 (6.8, 18.3) vs 10.7 (5.5, 17.3) mmHg; P &amp;lt; .01]. Neither higher diuretic dose, twice-daily dosing, nor atrial fibrillation modified this diurnal variation (P = .98, P = .50). Patients who suffered ADHF events demonstrated higher left atrial pressures [14.3 (9.5, 19.9) vs 10.4 (5.4, 17.3) mmHg, P &amp;lt; .01]. Higher LAP was also independently associated with increased risk of ADHF events (OR 1.40, 95% CI 1.10\u20131.78; P &amp;lt; .01). Diurnal variation was present irrespective of acute decompensated heart failure status (P = .79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Using direct ambulatory intracardiac LAP monitoring, we observed consistent diurnal variation with higher evening pressures, largely unchanged by diuretic dose or dosing schedule, atrial fibrillation, or association with ADHF events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration numbers<\/jats:title>\n                    <jats:p>NCT03775161, NCT05448833, NCT05712824, NCT06147336.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag280","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:16:39Z","timestamp":1788164199000},"source":"Crossref","is-referenced-by-count":0,"title":["Diurnal variation in left atrial pressure in ambulatory patients with chronic heart failure"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6781-3903","authenticated-orcid":false,"given":"Yuval","family":"Amir","sequence":"first","affiliation":[{"name":"Rabin Medical Center-Beilinson Hospital Internal Medicine B Department, , 39 Jabotinsky Street, Petah-Tikva 4941492 ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviv","family":"Shaul","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rabin Medical Center\u2014Beilinson Hospital , Petah-Tikva ,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oran","family":"Koren","sequence":"additional","affiliation":[{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Merav","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University , Jerusalem ,","place":["Israel"]},{"name":"Hebrew University of Jerusalem School of Computer Science and Engineering, , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyamin","family":"Ben Avraham","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rabin Medical Center\u2014Beilinson Hospital , Petah-Tikva ,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6941-1738","authenticated-orcid":false,"given":"Tuvia","family":"Ben Gal","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rabin Medical Center\u2014Beilinson Hospital , Petah-Tikva ,","place":["Israel"]},{"name":"Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Meerkin","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center Jesselson Integrated Heart Center, , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Laconelli","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow ,","place":["UK"]},{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS Department of Cardiovascular Medicine, , L.go A. Gemelli, 1, 00168 Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del Trigo","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda, Hospital Universitario Puerta de Hierro , Majadahonda, Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio J","family":"Amat-Santos","sequence":"additional","affiliation":[{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red - Enfermedades cardiovasculares (CIBERCV) , Madrid ,","place":["Spain"]},{"name":"University Clinic Hospital of Valladolid Cardiology Department, , Valladolid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Abdul-Jawad","family":"Altisent","sequence":"additional","affiliation":[{"name":"Institut Clinic Cardiovascular (ICCV), Hospital Cl\u00ednic de Barcelona, University of Barcelona , Barcelona ,","place":["Spain"]},{"name":"Insititut d\u2019Investigacions biom\u00e8diques Agust\u00ed Pi i Sunyer (IDIBAPS) , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikheil","family":"Metreveli","sequence":"additional","affiliation":[{"name":"Cardiology Department, Jerarsi Clinic , Tbilisi ,","place":["Georgia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Ayalon","sequence":"additional","affiliation":[{"name":"Cardiovascular Section, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitaramesh","family":"Emani","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center , Columbus, OH 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