{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:37:59Z","timestamp":1792604279467,"version":"4.5.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Glucagon-like peptide-1 (GLP-1) receptor agonists reduce major adverse cardiovascular events among patients with diabetes, overweight and obesity. Whether these benefits extend to patients undergoing aortic valve replacement (AVR) for severe aortic stenosis (AS) remains unknown. Thus, we investigated the association between GLP-1 receptor agonist treatment and cardiovascular outcomes after AVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nationwide population-based cohort study including consecutive patients with severe AS undergoing transcatheter aortic valve implantation or surgical aortic valve replacement in Western Denmark between January 2016 and April 2022. Patients were followed until death, emigration, crossover, or end of follow-up on 12 May 2026. Propensity score-matching was performed to balance confounding. The primary outcome was a composite of all-cause mortality, heart failure hospitalization, or aortic valve reoperation. Secondary outcomes included all-cause mortality, heart failure hospitalization, and aortic valve reoperation, with analyses accounting for the competing risk of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 5259 eligible patients undergoing AVR, 292 propensity score-matched patients were included in the final analyses. During a mean follow-up of 4.8 \u00b1 2.4 years, GLP-1 receptor agonist treatment was associated with a lower risk of the primary composite outcome compared with controls [hazard ratios (HR) .69, 95% confidence intervals (CI) .50\u2013.96, P = .029]. GLP-1 receptor agonist treatment was also associated with lower risk of all-cause mortality (HR .66, 95% CI .46\u2013.95, P = .025). In competing risk analyses accounting for death, lower risks were observed for heart failure hospitalization (HR .67, 95% CI .48\u2013.93, P = .018), and aortic valve reoperation (HR .69, 95% CI .49\u2013.98, P = .037).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with GLP-1 receptor agonists was associated with lower risk of cardiovascular outcomes, including mortality, following AVR among patients with severe AS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag313","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:53:58Z","timestamp":1792065238000},"source":"Crossref","is-referenced-by-count":0,"title":["GLP-1 receptor agonist treatment and cardiovascular outcomes following aortic valve replacement: a nationwide observational study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8048-9779","authenticated-orcid":false,"given":"Lytfi","family":"Krasniqi","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , J. B. Winsl\u00f8wsvej 4, 5000 Odense ,","place":["Denmark"]},{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 1st Street Southwest, Rochester, MN 55905 ,","place":["USA"]},{"name":"Department of Clinical Research, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-5685","authenticated-orcid":false,"given":"Mohanad","family":"Hamandi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 1st Street Southwest, Rochester, MN 55905 ,","place":["USA"]},{"name":"Department of Clinical Research, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]},{"name":"Department of Cardiology, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poul Erik","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , J. 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Winsl\u00f8wsvej 4, 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0842-3644","authenticated-orcid":false,"given":"Henrik","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-3521","authenticated-orcid":false,"given":"Patricia A","family":"Pellikka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 1st Street Southwest, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-0596","authenticated-orcid":false,"given":"Barry A","family":"Borlaug","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 1st Street Southwest, Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6335-3303","authenticated-orcid":false,"given":"Oke","family":"Gerke","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]},{"name":"Department of Nuclear Medicine, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5747-6839","authenticated-orcid":false,"given":"Amal","family":"Haujir","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic , 200 1st Street Southwest, Rochester, MN 55905 ,","place":["USA"]},{"name":"Department of Clinical Research, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]},{"name":"Department of Cardiology, Odense University Hospital , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5200-9416","authenticated-orcid":false,"given":"Louise Oeksnebjerg","family":"Krasniqi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , J. B. Winsl\u00f8wsvej 4, 5000 Odense ,","place":["Denmark"]},{"name":"Department of Clinical Research, University of Southern Denmark , 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-9551","authenticated-orcid":false,"given":"Christian Juhl","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6898-2715","authenticated-orcid":false,"given":"Lars Peter","family":"Riber","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , J. B. 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