{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T11:21:02Z","timestamp":1794655262447,"version":"4.9.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020604","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020604","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GRASP-HF"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n The Global Registries and Surveys Programme\u2013Heart Failure (GRASP-HF) is a prospective, multicentre, international observational study assessing implementation of the 2021\/2023 ESC-HF guidelines. GRASP-HF is aligned with the Improving Care through Accreditation and Recognition in Heart Failure (ICARe-HF) programme, which links centre characteristics with guideline-implementation performance.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To compare baseline characteristics, guideline-directed medical therapy (GDMT) implementation, and in-hospital outcomes between GRASP-HF patients managed in centres participating or not participating in the ICARe-HF programme.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n GRASP-HF patients were stratified by ICARe-HF participation, clinical settings, acute (AHF) vs chronic HF (CHF) and ejection fraction (EF) subtypes. Hierarchical multivariable logistic regression models evaluated associations with quadruple therapy implementation and in-hospital mortality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 10 936 patients (63.3% CHF, 36.7% AHF), patients from ICARe-HF participating centres (51.3%) were older, more comorbid, but with less severe congestion. In both CHF and AHF, ICARe-HF centres demonstrated greater GDMT utilization, particularly angiotensin receptor\u2013neprilysin inhibitors and sodium\u2013glucose-cotransporter-2 inhibitors. In HFrEF, quadruple therapy was more frequently implemented (47% vs 40% in CHF; 27% vs 24% at AHF discharge) and remained associated with ICARe-HF participation after adjustment, odds ratio (OR) = 1.73, 95% confidence interval (CI): 1.17\u20132.55. Target doses remained suboptimal, particularly after AHF. Although crude in-hospital mortality was lower in ICARe-HF centres (2.3% vs 5.5%), this association was attenuated after multivariable adjustment (OR = 0.87, 95% CI: 0.48\u20131.56).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Participation in the ICARe-HF programme was associated with more comprehensive implementation of contemporary GDMT, particularly in HFrEF. The association with in-hospital mortality was attenuated after adjustment and should be considered exploratory.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ejhf\/xuag317","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:27:47Z","timestamp":1791804467000},"source":"Crossref","is-referenced-by-count":0,"title":["Baseline characteristics and utilization of medical therapies in acute hospitalized and chronic heart failure patients enrolled in GRASP-HF: differences between ICARe-HF and Non-ICARe-HF centres"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-3628","authenticated-orcid":false,"given":"Ovidiu","family":"Chioncel","sequence":"first","affiliation":[{"name":"Emergency Institute for Cardiovascular Diseases \u2018Prof. Dr. C.C. 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