{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:16:46Z","timestamp":1780377406696,"version":"3.54.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T00:00:00Z","timestamp":1582934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyaluronic acid (HA) is a major molecular component of the articular cartilage of the temporomandibular joint (TMJ) influencing joint lubrication. Functional lateral shift of the mandible (FLSM) can lead to malocclusion. This study investigated the effects of FLSM on HA metabolism and lubrication of the TMJ in growing rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty 5-week-old male Wistar rats were divided into shift, recovery, and control groups. Rats in the shift and recovery groups were fitted with guiding plates to produce a 2-mm FLSM which were removed from the rats in the recovery group 14 days later. Animals were sacrificed at 14 and 28 days after the appliances were attached. Immunohistochemistry of HA-binding protein (HABP), hyaluronan synthase (HAS), and hyaluronoglucosaminidases (HYALs) was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The thickness of HABP-positively stained areas in the lateral regions in the bilateral condyle was reduced during the experimental period in the shift group compared with that in the control group. The proportion of HAS2-stained areas was bilaterally decreased in different regions of condylar cartilage during the experimental period in the shift group. The reduction of the HYAL2-stained area proportion in the condylar cartilage was more significant than that of HYAL1 at 14 days after appliance attachment in the shift group. HAS2 staining was not recovered in the recovery group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>This research was based on animal experiments with a limited experimental period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FLSM altered lubrication related HA metabolism in the articular cartilage of the TMJ in growing rats.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejo\/cjaa012","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T12:07:25Z","timestamp":1580126845000},"page":"658-663","source":"Crossref","is-referenced-by-count":10,"title":["Effect of functional lateral shift of the mandible on hyaluronic acid metabolism related to lubrication of temporomandibular joint in growing rats"],"prefix":"10.1093","volume":"42","author":[{"given":"Xiyuan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ippei","family":"Watari","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,29]]},"reference":[{"key":"2020120204465865700_CIT0001","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.11607\/jomi.te20","article-title":"Temporomandibular disorders: a review of etiology, clinical management, and tissue engineering strategies","volume":"28","author":"Murphy","year":"2013","journal-title":"The International Journal of Oral & Maxillofacial Implants"},{"key":"2020120204465865700_CIT0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jdsr.2013.07.004","article-title":"Growth of the mandible and biological characteristics of the mandibular condylar cartilage","volume":"49","author":"Mizoguchi","year":"2013","journal-title":"Japanese Dental Science Review"},{"key":"2020120204465865700_CIT0003","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s11914-018-0447-7","article-title":"Part I: development and physiology of the temporomandibular joint","volume":"16","author":"Stocum","year":"2018","journal-title":"Current Osteoporosis Reports"},{"key":"2020120204465865700_CIT0004","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/ejo\/cjw003","article-title":"Association between posterior crossbite, skeletal, and muscle asymmetry: a systematic review","volume":"38","author":"Iodice","year":"2016","journal-title":"European Journal of Orthodontics"},{"key":"2020120204465865700_CIT0005","doi-asserted-by":"crossref","DOI":"10.1002\/9781118853719","volume-title":"Essentials of Orthodontics: Diagnosis and Treatment","author":"Staley","year":"2011"},{"key":"2020120204465865700_CIT0006","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2319\/041012-299.1","article-title":"Three-dimensional evaluation of facial asymmetry in association with unilateral functional crossbite in the primary, early, and late mixed dentition phases","volume":"83","author":"Primozic","year":"2013","journal-title":"The Angle Orthodontist"},{"key":"2020120204465865700_CIT0007","first-page":"569","article-title":"Unilateral posterior crossbite with mandibular shift: a review","volume":"71","author":"Kennedy","year":"2005","journal-title":"Journal (Canadian Dental Association)"},{"key":"2020120204465865700_CIT0008","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2319\/080808-417.1","article-title":"Functional lateral shift of the mandible effects on the expression of ECM in rat temporomandibular cartilage","volume":"79","author":"Wattanachai","year":"2009","journal-title":"The Angle Orthodontist"},{"key":"2020120204465865700_CIT0009","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.archoralbio.2012.01.006","article-title":"Effect of functional shift of the mandible on lubrication of the temporomandibular joint","volume":"57","author":"Kure-Hattori","year":"2012","journal-title":"Archives of Oral Biology"},{"key":"2020120204465865700_CIT0010","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1177\/0022034514535807","article-title":"Lubricin is required for the structural integrity and post-natal maintenance of TMJ","volume":"93","author":"Koyama","year":"2014","journal-title":"Journal of Dental Research"},{"key":"2020120204465865700_CIT0011","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/ejo\/21.2.155","article-title":"The functional shift of the mandible in unilateral posterior crossbite and the adaptation of the temporomandibular joints: a pilot study","volume":"21","author":"Nerder","year":"1999","journal-title":"European Journal of Orthodontics"},{"key":"2020120204465865700_CIT0012","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12934-016-0517-4","article-title":"Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms","volume":"15","author":"de Oliveira","year":"2016","journal-title":"Microbial Cell Factories"},{"key":"2020120204465865700_CIT0013","doi-asserted-by":"crossref","first-page":"397","DOI":"10.17221\/1930-VETMED","article-title":"Hyaluronic acid (hyaluronan): a review","volume":"53","author":"Necas","year":"2008","journal-title":"Veterinarni Medicina"},{"key":"2020120204465865700_CIT0014","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","article-title":"Hyaluronan: a simple polysaccharide with diverse biological functions","volume":"10","author":"Dicker","year":"2014","journal-title":"Acta Biomaterialia"},{"key":"2020120204465865700_CIT0015","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1039\/b907155e","article-title":"Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces","volume":"5","author":"Chang","year":"2009","journal-title":"Soft Matter"},{"key":"2020120204465865700_CIT0016","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.4081\/ejh.2010.e50","article-title":"Expression of hyaluronan synthase 3 in deformed human temporomandibular joint discs: in vivo and in vitro studies","volume":"54","author":"Matsumoto","year":"2010","journal-title":"European Journal of Histochemistry"},{"key":"2020120204465865700_CIT0017","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00018-007-7360-z","article-title":"Hyaluronan synthesis and degradation in cartilage and bone","volume":"65","author":"Bastow","year":"2008","journal-title":"Cellular and Molecular Life Sciences"},{"key":"2020120204465865700_CIT0018","doi-asserted-by":"crossref","first-page":"25085","DOI":"10.1074\/jbc.274.35.25085","article-title":"Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties","volume":"274","author":"Itano","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"2020120204465865700_CIT0019","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fimmu.2016.00039","article-title":"Editorial: interaction between hyaluronic acid and its receptors (CD44, RHAMM) regulates the activity of inflammation and cancer","volume":"7","author":"Naor","year":"2016","journal-title":"Frontiers in Immunology"},{"key":"2020120204465865700_CIT0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3233\/BIR-1994-31302","article-title":"Viscoelasticity of hyaluronic acid with different molecular weights","volume":"31","author":"Kobayashi","year":"1994","journal-title":"Biorheology"},{"key":"2020120204465865700_CIT0021","first-page":"3","article-title":"Viscosupplementation: a new concept in the treatment of osteoarthritis","volume":"39","author":"Balazs","year":"1993","journal-title":"The Journal of Rheumatology. Supplement"},{"key":"2020120204465865700_CIT0022","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0945-053X(01)00172-X","article-title":"The six hyaluronidase-like genes in the human and mouse genomes","volume":"20","author":"Csoka","year":"2001","journal-title":"Matrix Biology: Journal of the International Society for Matrix Biology"},{"key":"2020120204465865700_CIT0023","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/joor.12443","article-title":"Hyaluronan metabolism in overloaded temporomandibular joint","volume":"43","author":"Shinohara","year":"2016","journal-title":"Journal of Oral Rehabilitation"},{"key":"2020120204465865700_CIT0024","doi-asserted-by":"crossref","first-page":"105R","DOI":"10.1093\/glycob\/cwg112","article-title":"Devising a pathway for hyaluronan catabolism: are we there yet?","volume":"13","author":"Stern","year":"2003","journal-title":"Glycobiology"},{"key":"2020120204465865700_CIT0025","first-page":"591","article-title":"Functional lateral deviation of the mandible and its positional recovery on the rat condylar cartilage during the growth period","volume":"76","author":"Sato","year":"2006","journal-title":"The Angle Orthodontist"},{"key":"2020120204465865700_CIT0026","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abr\u00e0moff","year":"2004","journal-title":"Biophotonics International"},{"key":"2020120204465865700_CIT0027","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00774-003-0421-y","article-title":"Effect of compressive forces on extracellular matrix in rat mandibular condylar cartilage","volume":"21","author":"Teramoto","year":"2003","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"2020120204465865700_CIT0028","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1002\/art.11305","article-title":"Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: involvement of reactive oxygen species","volume":"48","author":"Yamazaki","year":"2003","journal-title":"Arthritis and Rheumatism"},{"key":"2020120204465865700_CIT0029","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10616-013-9669-9","article-title":"Hyaluronic acid secretion by synoviocytes alters under cyclic compressive load in contracted collagen gels","volume":"67","author":"Uehara","year":"2015","journal-title":"Cytotechnology"},{"key":"2020120204465865700_CIT0030","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1093\/hmg\/ddn088","article-title":"A mouse model of human mucopolysaccharidosis IX exhibits osteoarthritis","volume":"17","author":"Martin","year":"2008","journal-title":"Human Molecular Genetics"},{"key":"2020120204465865700_CIT0031","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1096\/fj.08-111997","article-title":"Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?","volume":"22","author":"Jadin","year":"2008","journal-title":"FASEB Journal"},{"key":"2020120204465865700_CIT0032","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbm.a.32540","article-title":"Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli","volume":"93","author":"Tanimoto","year":"2010","journal-title":"Journal of Biomedical Materials Research. Part A"},{"key":"2020120204465865700_CIT0033","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.archoralbio.2007.07.011","article-title":"Regulation of HAS expression in human synovial lining cells of TMJ by IL-1beta","volume":"53","author":"Li","year":"2008","journal-title":"Archives of Oral Biology"},{"key":"2020120204465865700_CIT0034","first-page":"249","article-title":"Activity of temporal and masseter muscles in children with a lateral forced bite","volume":"45","author":"Ingervall","year":"1975","journal-title":"The Angle Orthodontist"},{"key":"2020120204465865700_CIT0035","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1067\/mod.2001.118626","article-title":"Changes in the masticatory cycle following treatment of posterior unilateral crossbite in children","volume":"120","author":"Throckmorton","year":"2001","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020120204465865700_CIT0036","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1067\/mod.2003.5","article-title":"Lateral functional shift of the mandible: Part I. Effects on condylar cartilage thickness and proliferation","volume":"123","author":"Fuentes","year":"2003","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020120204465865700_CIT0037","first-page":"624","article-title":"The laboratory rat: relating its age with human\u2019s","volume":"4","author":"Sengupta","year":"2013","journal-title":"International Journal of Preventive Medicine"},{"key":"2020120204465865700_CIT0038","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.archoralbio.2015.01.008","article-title":"Effect of asymmetric force on the condylar cartilage, subchondral bone and collagens in the temporomandibular joints","volume":"60","author":"Zhang","year":"2015","journal-title":"Archives of Oral Biology"},{"key":"2020120204465865700_CIT0039","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1590\/S0102-86502010000300012","article-title":"Comparison between human and rat TMJ: anatomic and histopathologic features","volume":"25","author":"Porto","year":"2010","journal-title":"Acta Cirurgica Brasileira"},{"key":"2020120204465865700_CIT0040","first-page":"391","article-title":"TMJ anatomy and animal models","volume":"3","author":"Herring","year":"2003","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/42\/6\/658\/34664871\/cjaa012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/42\/6\/658\/34664871\/cjaa012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T19:01:07Z","timestamp":1722366067000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/42\/6\/658\/5766618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,29]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,2,29]]},"published-print":{"date-parts":[[2020,12,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjaa012","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,2,29]]}}}