{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:59:00Z","timestamp":1778774340831,"version":"3.51.4"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Izmir Katip Celebi University","award":["2016 \u2013TDR-SABE-0026"],"award-info":[{"award-number":["2016 \u2013TDR-SABE-0026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Orthodontic treatment is a long process that requires patient cooperation. Risks of side effects such as caries formation, periodontal problems, and root resorption increases as well as problems in patient cooperation arises with longer treatments. Several different techniques were developed that may shorten the treatment time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the effectiveness of micro-osteoperforations (MOPs) performed during the alignment stage.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial design<\/jats:title>\n                  <jats:p>Randomized controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-eight subjects who had crowding in the mandibular arch were included in the study. The first group (4 boys and 10 girls, mean age = 17.21 \u00b1 3.76 years) was treated with MOP (MOP) and the second group (8 boys and 6 girls, mean age = 15.29 \u00b1 1.77 years) was treated without MOP (control). Cephalometric variables, periodontal parameters, Little irregularity index, alignment duration, patient satisfaction, and ease of operation were evaluated. The level of statistical significance was P \u2264 0.05.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Alignment duration was shorter (P = 0.000) in the MOP group (105.57 \u00b1 18.34 days) compared to control group (135.86 \u00b1 15.12 days). Alleviating of the crowding was more in the MOP group, compared to the control group in all time points. The pain level in the MOP group in the first appointment was higher compared to control group (P = 0.002). There was no significant difference between the groups in cephalometric parameters. Higher increases were found for gingival index (P = 0.008) and bleeding index (P = 0.039) in the control group compared to MOP group at the end of treatment<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>The study was a single-centre study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Alignment stage was shortened with MOP application. There was no difference between groups for patient satisfaction and pain level except for the first appointment. No difference was observed between the groups regarding cephalometric values. Clinically insignificant inflammation was observed in periodontal tissues for both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>This study was registered at the Clinical Trials Registry (ClinicalTrials.gov NCT03652454).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjad017","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T16:45:01Z","timestamp":1683823501000},"page":"505-516","source":"Crossref","is-referenced-by-count":5,"title":["The effect of micro-osteoperforation on the rate of tooth movement during the alignment stage in patients with mandibular crowding: a randomised controlled trial"],"prefix":"10.1093","volume":"45","author":[{"given":"Mucahid","family":"Faik Sahin","sequence":"first","affiliation":[{"name":"Private Practice , Bursa , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-0684","authenticated-orcid":false,"given":"Asli","family":"Baysal","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Izmir Katip Celebi University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2023091805145911400_CIT0001","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2319\/020308-60.1","article-title":"Effects of corticision on paradental remodeling in orthodontic tooth movement","volume":"79","author":"Kim","year":"2009","journal-title":"Angle Orthodontist"},{"key":"2023091805145911400_CIT0002","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/2196-1042-14-42","article-title":"Acceleration of tooth movement during orthodontic treatment-a frontier in orthodontics","volume":"14","author":"Nimeri","year":"2013","journal-title":"Progress in Orthodontics"},{"key":"2023091805145911400_CIT0003","first-page":"3","article-title":"The regional acceleratory phenomenon: a review","volume":"31","author":"Frost","year":"1983","journal-title":"Henry Ford Hospital Medical Journal"},{"key":"2023091805145911400_CIT0004","first-page":"9","article-title":"Rapid orthodontics with alveolar reshaping: two case reports of decrowding","volume":"21","author":"Wilcko","year":"2001","journal-title":"The International Journal of Periodontics and Restorative Dentistry"},{"key":"2023091805145911400_CIT0005","first-page":"342","article-title":"Piezocision: a minimally invasive, periodontally accelerated orthodontic tooth movement procedure","volume":"30","author":"Dibart","year":"2009","journal-title":"Compendium of Continuing Education in Dentistry"},{"key":"2023091805145911400_CIT0006","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.ajodo.2013.06.017","article-title":"Effect of micro-osteoperforations on the rate of tooth movement","volume":"144","author":"Alikhani","year":"2013","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2023091805145911400_CIT0007","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1177\/0022034510373764","article-title":"Cytokine expression and accelerated tooth movement","volume":"89","author":"Teixeira","year":"2010","journal-title":"Journal of Dental Research"},{"key":"2023091805145911400_CIT0008","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.ajodo.2013.11.019","article-title":"Surgically facilitated orthodontic treatment: a systematic review","volume":"145","author":"Hoogeveen","year":"2014","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2023091805145911400_CIT0009","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1053\/j.sodo.2015.06.002","article-title":"Micro-osteoperforations: minimally invasive accelerated tooth \u00admovement","volume":"21","author":"Alikhani","year":"2015","journal-title":"Seminars in Orthodontics"},{"key":"2023091805145911400_CIT0010","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/14653125.2018.1528746","article-title":"Comparison of rate of tooth movement and pain perception during accelerated tooth movement associated with conventional fixed appliances with micro- osteoperforations\u2014a randomised controlled trial","volume":"45","author":"Attri","year":"2018","journal-title":"Journal of Orthodontics"},{"key":"2023091805145911400_CIT0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4041\/kjod.2021.51.3.157","article-title":"The effect of different micro-osteoperforation depths on the rate of orthodontic tooth movement: a single-center, single-blind, randomized clinical trial","volume":"51","author":"Haliloglu-Ozkan","year":"2021","journal-title":"Korean Journal of Orthodontics"},{"key":"2023091805145911400_CIT0012","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejwf.2018.04.002","article-title":"The use of micro-osteoperforation concept for accelerating differential tooth movement","volume":"7","author":"Feizbakhsh","year":"2018","journal-title":"Journal of World Federation of Orthodontics"},{"key":"2023091805145911400_CIT0013","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2319\/011518-47.1","article-title":"Mini-implant supported canine retraction with microosteoperforation: a split-mouth randomized clinical trial","volume":"89","author":"Sivarajan","year":"2019","journal-title":"Angle Orthodontist"},{"key":"2023091805145911400_CIT0014","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.ajodo.2017.11.026","article-title":"Three-dimensional assessment of the effect of micro-osteoperforations on the rate of tooth movement during canine retraction in adults with Class II malocclusion: a randomized controlled clinical trial","volume":"153","author":"Alkebsi","year":"2018","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2023091805145911400_CIT0015","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2319\/110819-707.1","article-title":"Micro-osteoperforation effectiveness on tooth movement rate and impact on oral health related quality of life: a randomized clinical trial","volume":"90","author":"Fattori","year":"2020","journal-title":"Angle Orthodontist"},{"key":"2023091805145911400_CIT0016","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jobcr.2021.01.010","article-title":"Effect of micro-osteoperforations on rate of space closure by mini-implant supported maxillary anterior en-masse retraction: a randomized clinical trial","volume":"11","author":"Raghav","year":"2021","journal-title":"Journal of Oral Biology and Craniofacial Research"},{"key":"2023091805145911400_CIT0017","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/ejo\/cjz049","article-title":"Effect of micro-osteoperforation on the rate of orthodontic tooth movement\u2014a systematic review and a meta-analysis","volume":"42","author":"Shahabee","year":"2020","journal-title":"European Journal of Orthodontics"},{"key":"2023091805145911400_CIT0018","first-page":"116","article-title":"Effect of flapless cortical perforation on canine retraction rate: a randomized clinical trial","volume":"25","author":"Kundi","year":"2018","journal-title":"International Medical Journal"},{"key":"2023091805145911400_CIT0019","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ajodo.2017.05.036","article-title":"Physical properties of root cementum: part 26. Effects of microosteoperforations on orthodontic root resorption: a microcomputed tomography study","volume":"153","author":"Chan","year":"2018","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2023091805145911400_CIT0020","article-title":"Efficiency of piezotome-corticision assisted orthodontics in alleviating mandibular anterior crowding\u2014a randomized controlled clinical trial","volume-title":"Master\u2019s Theses","author":"Mehr","year":"2013"},{"key":"2023091805145911400_CIT0021","article-title":"Efficiency of piezotome-corticision assisted orthodontics in alleviating mandibular anterior crowding\u2014a randomized controlled clinical trial","volume-title":"Master\u2019s Theses","author":"Davoody","year":"2015"},{"key":"2023091805145911400_CIT0022","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/jos.JOS_112_18","article-title":"Effects of mini-implant facilitated micro-osteoperforations in alleviating mandibular anterior crowding: a randomized controlled clinical trial","volume":"8","author":"Bansal","year":"2019","journal-title":"Journal of Orthodontic Science"},{"key":"2023091805145911400_CIT0023","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/ejo\/cjw091","article-title":"Efficiency of piezotome-corticision assisted orthodontics in alleviating mandibular anterior crowding\u2014a randomized clinical trial","volume":"39","author":"Uribe","year":"2017","journal-title":"European Journal of Orthodontics"},{"key":"2023091805145911400_CIT0024","author":"Propel orthodontics products-Treatment guide"},{"key":"2023091805145911400_CIT0025","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0002-9416(75)90086-X","article-title":"The irregularity index: a quantitative score of mandibular anterior alignment","volume":"68","author":"Little","year":"1975","journal-title":"American Journal of Orthodontics"},{"key":"2023091805145911400_CIT0026","first-page":"303","article-title":"The thickness of periodontal soft tissue ultrasonic examination\u2014current possibilities and perspectives","volume":"48","author":"Bednarz","year":"2011","journal-title":"Dental and Medical Problems"},{"key":"2023091805145911400_CIT0027","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s002239900508","article-title":"Influence of inflammation-mediated osteopenia on the regional acceleratory phenomenon and the systemic acceleratory phenomenon during healing of a bone defect in the rat","volume":"63","author":"Schilling","year":"1998","journal-title":"Calcified Tissue International"},{"key":"2023091805145911400_CIT0028","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2319\/012215-49.1","article-title":"Accelerated tooth movement with piezocision and its periodontal-transversal effects in patients with Class II malocclusion","volume":"86","author":"Aksakalli","year":"2015","journal-title":"Angle Orthodontist"},{"key":"2023091805145911400_CIT0029","first-page":"247","article-title":"Biomechanics, mechanics and contemporary orthodontic appliances","volume-title":"Contemporary Orthodontics","author":"Proffit","year":"2018"},{"key":"2023091805145911400_CIT0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1053\/j.sodo.2014.06.005","article-title":"Stability of the mandibular dental arch following periodontally accelerated osteogenic orthodontics therapy: preliminary studies","volume":"20","author":"Ferguson","year":"2014","journal-title":"Seminars in Orthodontics"},{"key":"2023091805145911400_CIT0031","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1601-6343.2010.01491.x","article-title":"Orthodontic therapy and gingival recession: a systematic review","volume":"13","author":"Joss-Vassalli","year":"2010","journal-title":"Orthodontics and Craniofacial Research"},{"key":"2023091805145911400_CIT0032","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12903-018-0635-y","article-title":"Combining virtual model and cone beam computed tomography to assess periodontal changes after anterior tooth movement","volume":"18","author":"Kim","year":"2018","journal-title":"BMC Oral Health"},{"key":"2023091805145911400_CIT0033","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1600-051X.1996.tb00621.x","article-title":"Ultrasonic determination of gingival thickness: subject variation and influence of tooth type and clinical features","volume":"23","author":"Eger","year":"1996","journal-title":"Journal of Clinical Periodontology"},{"key":"2023091805145911400_CIT0034","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aanat.2014.02.010","article-title":"Assessment of gingival thickness using an ultrasonic dental system prototype: a comparison to traditional methods","volume":"199","author":"Slak","year":"2015","journal-title":"Annals of Anatomy"},{"key":"2023091805145911400_CIT0035","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ajodo.2015.09.029","article-title":"Evaluation of corticotomy-facilitated orthodontics and piezocision in rapid canine retraction","volume":"149","author":"Abbas","year":"2016","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2023091805145911400_CIT0036","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.ajodo.2012.12.014","article-title":"Sequential piezocision: a novel approach to accelerated orthodontic treatment","volume":"144","author":"Keser","year":"2013","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2023091805145911400_CIT0037","doi-asserted-by":"crossref","first-page":"170180","DOI":"10.1053\/j.sodo.2015.06.003","article-title":"Piezocision\u2122-assisted orthodontics: past, present, and future","volume":"21","author":"Dibart","year":"2015","journal-title":"Seminars in Orthodontics"},{"key":"2023091805145911400_CIT0038","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2319\/052015-343.1","article-title":"Comparison of the effects of micro-osteoperforation and corticision on the rate of orthodontic tooth movement in rats","volume":"86","author":"Tsai","year":"2015","journal-title":"Angle Orthodontist"},{"key":"2023091805145911400_CIT0039","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/00016350310003242","article-title":"Effect of a triclosan-containing dental gel on the levels of prostaglandin I2 and interleukin-1 \u03b2 in gingival crevicular fluid from adolescents with fixed orthodontic appliances","volume":"61","author":"Sk\u00f6ld-Larsson","year":"2003","journal-title":"Acta Odontologica Scandinavica"},{"key":"2023091805145911400_CIT0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/ejo\/cjm050","article-title":"Periodontal conditions in subjects following orthodontic therapy. A preliminary study","volume":"29","author":"Gomes","year":"2007","journal-title":"European Journal of Orthodontics"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/45\/5\/505\/51609633\/cjad017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/45\/5\/505\/51609633\/cjad017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T07:16:27Z","timestamp":1695021387000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/45\/5\/505\/7160237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,11]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,11]]},"published-print":{"date-parts":[[2023,9,18]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjad017","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10,1]]},"published":{"date-parts":[[2023,5,11]]}}}