{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:22:42Z","timestamp":1756995762330,"version":"3.37.3"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["287953"],"award-info":[{"award-number":["287953"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in vivo.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>The maxillary right first molars of male Wistar rats (n = 21) were moved mesially for 14 days, with submucosal injection of two dosages of irisin (0.1 or 1 \u03bcg) or phosphate-buffered saline (control) every third day. OTM was recorded by feeler gauge and micro-computed tomography (\u03bcCT). Alveolar bone and root volume were analysed using \u03bcCT, and plasma irisin levels by ELISA. Histological characteristics of PDL tissues were examined, and the expression of collagen type I, periostin, osteocalcin (OCN), von Willebrand factor (vWF) and fibronectin type III domain-containing protein 5 (FNDC5) in PDL was evaluated by immunofluorescence staining.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Repeated 1 \u03bcg irisin injections suppressed OTM on days 6, 9, and 12. No significant differences were observed in OTM in the 0.1 \u03bcg irisin group, or in bone morphometric parameters, root volume or plasma irisin, compared to control. Resorption lacunae and hyalinization were found at the PDL-bone interface on the compression side in the control, whereas they were scarce after irisin administration. The expression of collagen type I, periostin, OCN, vWF, and FNDC5 in PDL was enhanced by irisin administration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>The feeler gauge method may overestimate OTM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Submucosal irisin injection reduced OTM by enhancing osteogenic potential of PDL, and this effect was more significant on the compression side.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjad021","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:53:30Z","timestamp":1684623210000},"page":"842-853","source":"Crossref","is-referenced-by-count":3,"title":["Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal 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Parreiras","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Oral Research Laboratory, Faculty of Dentistry, University of Oslo , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unni","family":"Syversen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU) , Trondheim , Norway"},{"name":"Department of Endocrinology, Clinic of Medicine, St. Olavs University Hospital , 7030 Trondheim , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne Elin","family":"Reseland","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, Faculty of Dentistry, University of Oslo , Oslo , 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