{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T21:38:23Z","timestamp":1785706703944,"version":"3.56.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"University of Adelaide Kwok Paul Lee Bequest"},{"DOI":"10.13039\/100009235","name":"Australian Society of Orthodontists\u2019 Foundation for Research and Education","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009235","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to examine the relative contributions of genetic and environmental influences on variation in dental arch form in individuals who have largely completed their craniofacial growth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and methods<\/jats:title>\n                  <jats:p>The subjects of this study comprised dental casts of 50 monozygotic twins and 24 dizygotic twins from the collection of records of twins housed at the Adelaide Dental School, Australia. The subjects were of Western European descent, with an average age of 20.93\u2005\u00b1\u20055.58 years. Dental casts were scanned using a 3D scanner to analyse the dental arch form. Landmark-based inter-arch and intra-arch measurements were performed. Structural equation modelling was employed to analyse the quantitative data using the normal assumptions of the twin model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Genetic modelling revealed that additive genetic and unique environmental factors best explained the observed variation for all occlusal traits measured, except for mandibular intercanine width. High heritability was observed for most intra-arch occlusal variables (0.61\u20130.85) including the maxillary and mandibular intercanine and intermolar widths, arch depth and perimeter. In contrast, moderate heritability was found for inter-arch occlusal variables (0.52\u20130.59) such as overjet and overbite. Sexual dimorphism was evident, with males displaying larger posterior arch width than females (P\u2005&amp;lt;\u20050.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>Our sample was limited to individuals of Western European ancestry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The predominant source of occlusal variation within this group of Australian twins of Western European descent was controlled by genetic effects, and most were highly heritable. Generally, intra-arch occlusal variables showed greater heritability compared with inter-arch occlusal variables.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjad054","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:59:04Z","timestamp":1697824744000},"page":"868-874","source":"Crossref","is-referenced-by-count":24,"title":["The genetic and environmental contributions to variation in the permanent dental arch form: a twin study"],"prefix":"10.1093","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3057-4877","authenticated-orcid":false,"given":"Ting-han","family":"Lin","sequence":"first","affiliation":[{"name":"Adelaide Dental School, The University of Adelaide , Adelaide , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8668-7744","authenticated-orcid":false,"given":"Toby","family":"Hughes","sequence":"additional","affiliation":[{"name":"Adelaide Dental School, The University of Adelaide , Adelaide , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-1079","authenticated-orcid":false,"given":"Maurice J","family":"Meade","sequence":"additional","affiliation":[{"name":"Adelaide Dental School, The University of Adelaide , Adelaide , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"2023113008164319900_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-55073-2","article-title":"Adolescent dental arch development among Southern Chinese in Hong Kong: a geometric morphometric approach","volume":"9","author":"Wen","year":"2019","journal-title":"Sci Rep"},{"key":"2023113008164319900_CIT0002","first-page":"518","article-title":"Long-term changes in arch form after orthodontic treatment and retention","volume-title":"Am J Orthod Dentofacial Orthop","author":"De la Cruz","year":"1995"},{"key":"2023113008164319900_CIT0003","first-page":"445","article-title":"Genetic influence on dental arch form in orthodontic patients","volume-title":"Angle Orthod","author":"Cassidy","year":"1998"},{"key":"2023113008164319900_CIT0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1179\/bjo.13.1.1","article-title":"On the aetiology of malocclusion. 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