{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:05:56Z","timestamp":1790971556334,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"School & Hospital of Stomatology, Wuhan University","award":["LYZX202002"],"award-info":[{"award-number":["LYZX202002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Agenesis of third molar agenesis has a higher incidence than other tooth development anomalies. Previous research identified a potential correlation between third molar agenesis and specific craniofacial morphology; however, no systematic review and meta-analysis on this topic currently exists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this systematic review and meta-analysis was to evaluate the association between third molar agenesis and craniofacial sagittal and vertical morphology.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Search methods<\/jats:title>\n                  <jats:p>An electronic search was conducted on PubMed, Embase, Web of Science, and the Cochrane Library without restrictions on publication year or language; this was supplemented by the manual retrieval of relevant literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Selection criteria<\/jats:title>\n                  <jats:p>Cross-sectional studies that compared craniofacial morphology using angular and linear measurements obtained from lateral cephalography between patients with third molar agenesis and those without were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data collection and analysis<\/jats:title>\n                  <jats:p>The quality assessment of the enrolled articles was evaluated by the Joanna Briggs Institute critical appraisal tool. Meta-analysis and sensitivity analysis were performed by Review Manager software (The Cochrane Collaborative, version 5.4, Cochrane IMS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of seven studies were included. Meta-analysis demonstrated that the ANB (mean differences (MD) = \u20130.75, 95% CI: \u20131.31 to \u20130.19, P &amp;lt; 0.01), palate length (ANS\u2013PNS, MD = \u20131.68, 95% CI: \u20132.24 to \u20131.11, P &amp;lt; 0.01), and mandibular length (Go-Pog, MD = \u20130.36, 95% CI: \u20130.59 to \u20130.13, P &amp;lt; 0.01) were smaller in patients with third molar agenesis. With regard to vertical craniofacial morphology, the mandibular plane angle (MP-FH; MD = \u20131.88, 95% CI: \u20133.45 to \u20130.31, P = 0.02), gonial angle (gonial angle; MD = \u20131.73, 95% CI: \u20132.69 to \u20130.77, P &amp;lt; 0.01) and lower face height (lower face heigh angle; MD = \u20131.36, 95% CI: \u20131.94 to \u20130.77, P &amp;lt; 0.01) were smaller in patients with third molar agenesis, indicating a flatter or brachyfacial skeletal pattern.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results of this study suggest that third molar agenesis maybe associated with a reduced maxillary length and a flatter mandible. However, these findings need to be interpreted with caution due to inconsistencies in the certainty of evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>PROSPERO (CRD42023448226).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjad081","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T11:29:40Z","timestamp":1704281380000},"source":"Crossref","is-referenced-by-count":6,"title":["The relationship between third molar agenesis and craniofacial morphology: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"46","author":[{"given":"Yushi","family":"Le","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University 430079 , China"},{"name":"Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, School and Hospital of Stomatology, Wuhan University , Wuhan 430079 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University 430079 , China"},{"name":"Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, School and Hospital of Stomatology, Wuhan University , Wuhan 430079 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University 430079 , China"},{"name":"Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, School and Hospital of Stomatology, Wuhan University , Wuhan 430079 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong , Hong Kong 999077 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University 430079 , China"},{"name":"Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, School and Hospital of Stomatology, 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