{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:23:00Z","timestamp":1777713780453,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>An update on the knowledge regarding the orthopedic\/orthodontic role in treating JIA-related dentofacial deformities is relevant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This systematic review aimed to assess the level of evidence regarding the management of dentofacial deformity from juvenile idiopathic arthritis (JIA) with orthodontics and\/or dentofacial orthopedics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Search methods<\/jats:title>\n                  <jats:p>The following databases were searched without time or language restrictions up to 31 January 2024 (Medline, Embase, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and Latin American and Caribbean Health Sciences Literature).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Selection criteria<\/jats:title>\n                  <jats:p>Inclusion criteria were studies dealing with JIA subjects receiving treatment with orthodontic and\/or dentofacial orthopedic functional appliances.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Data collection and analysis<\/jats:title>\n                  <jats:p>After the removal of duplicate studies, data extraction, and risk of bias assessment according to ROBINS-I guidelines were conducted. Data extraction was conducted by two independent authors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The electronic database search identified 397 eligible articles after the removal of duplicates. Following the application of the pre-defined inclusion and exclusion criteria, 11 articles were left for inclusion. Two trials were associated with a severe risk of bias, four trials were at moderate risk of bias, and the other five presented a low risk of bias. Various research groups employed and documented the effects of different types of appliances and methodologies. The study heterogeneity did not allow for meta-analyses. In addition, a lack of uniformity in treatment objectives was observed across the included studies. After treatment with dentofacial orthopedics skeletal improvement was demonstrated in 10 studies, and a decrease in orofacial signs and symptoms was reported in 7 studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Across the available literature, there is minor evidence to suggest that dentofacial orthopedics may be beneficial in the management of dentofacial deformities from JIA. There is little evidence to suggest that it can reduce orofacial signs and symptoms in patients with JIA. Based on current evidence, it is not possible to outline clinical recommendations for specific aspects of orthopedic management in growing subjects with JIA-related dentofacial deformity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registration<\/jats:title>\n                  <jats:p>PROSPERO (CRD42023390746).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjae023","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T21:41:51Z","timestamp":1718142111000},"source":"Crossref","is-referenced-by-count":3,"title":["Orthodontic and orthopedic management of dentofacial deformity from juvenile idiopathic arthritis: a systematic literature review"],"prefix":"10.1093","volume":"46","author":[{"given":"Rossana Patricia","family":"Rotolo","sequence":"first","affiliation":[{"name":"University of Campania Luigi Vanvitelli Department of Precision Medicine, , Via De Crecchio n. 6, 80138 Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akila","family":"Aiyar","sequence":"additional","affiliation":[{"name":"Aarhus University Section of Orthodontics, Department of Dentistry and Oral Health, , Vennelyst Boulevard 9, Building 1613, DK 8000 Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Perillo","sequence":"additional","affiliation":[{"name":"University of Campania Luigi Vanvitelli Multidisciplinary Department of Medical-Surgical and Dental Specialties, Orthodontic Program, , Via De Crecchio n. 6, 80138 Naples , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Klit","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus University Section of Orthodontics, Department of Dentistry and Oral Health, , Vennelyst Boulevard 9, Building 1613, DK 8000 Aarhus , Denmark"},{"name":"Aarhus University Hospital Department of Oral and Maxillofacial Surgery, , Vennelyst Boulevard 9, Building 1613, DK 8000 Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Stoustrup","sequence":"additional","affiliation":[{"name":"Aarhus University Section of Orthodontics, Department of Dentistry and Oral Health, , Vennelyst Boulevard 9, Building 1613, DK 8000 Aarhus , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"2024072915250885900_CIT0001","first-page":"1991","article-title":"Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997","volume":"25","author":"Petty","year":"1998","journal-title":"Journal of Rheumatology"},{"key":"2024072915250885900_CIT0002","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 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