{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:04:24Z","timestamp":1790024664658,"version":"4.0.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["#405284\/2018-7"],"award-info":[{"award-number":["#405284\/2018-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to evaluate zoledronic acid (ZOL) induced alterations in the alveolar bone, periodontal ligament, and cementum under orthodontic forces in mice of different ages, focusing on the early and late half-life of ZOL administration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Juvenile (6-week; n\u2005=\u200530) and adult (12-week; n\u2005=\u200520) mice (C57BL\/6J) were divided into five groups, with three groups receiving a single ZOL dose. A 0.35\u00a0N orthodontic force was applied 1 and 12 weeks after ZOL administration. Alveolar bone, cementum, periodontal ligament response, osteoclast activity, calcium and 1,25(OH)2D3 levels were assessed at 12\u00a0h and 12 weeks after force application.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ZOL reduced tooth displacement and osteoclast counts in the adult and juvenile (latency phase of medication) groups compared to the juvenile control group (P\u2005&amp;lt;\u2005.05). The thickness of the periodontal ligament and number of blood vessels decreased moderately in adult mice and slightly in juveniles (P\u2005&amp;lt;\u2005.05), particularly in the ZOL-treated groups. Cementum resorption and alveolar crest irregularities were observed in all the ZOL-treated groups. Juvenile mice that underwent force application 12 weeks after ZOL administration exhibited responses similar to those observed in adult mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>This study demonstrated that the periodontal ligament and alveolar bone of juvenile and adult mice respond differently to ZOL treatment. However, the mechanisms underlying these differential effects remain unclear, highlighting the need for further investigation of bone remodeling markers to better understand the impact of ZOL during both the active and latency phases in young and adult subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ZOL intake influenced the alveolar bone, periodontal ligament, cementum, blood vessel count, and tooth displacement under orthodontic force. The extent of these changes was age dependent, with distinct effects observed in juvenile and adult mice. Juvenile mice analyzed in the latency phase of medication exhibited behaviors resembling those of adult mice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjaf032","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T08:45:23Z","timestamp":1754124323000},"source":"Crossref","is-referenced-by-count":2,"title":["Age-dependent impact of Zoledronic acid on periodontal structures under orthodontic loading"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3313-2152","authenticated-orcid":false,"given":"Ana Zilda Nazar","family":"Bergamo","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo , Avenida do Caf\u00e9, s\/n. Ribeir\u00e3o Preto\/SP 14040-904 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9 Albuquerque","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School (FMRP), University of S\u00e3o Paulo , Av. Bandeirantes, 3900, Ribeir\u00e3o Preto-SP 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Corr\u00eaa Viana","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry of Piracicaba, University of Campinas , Av. Limeira, 90. Piracicaba, SP 13414-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Fernanda","family":"Duffles","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo , Avenida do Caf\u00e9, s\/n. Ribeir\u00e3o Preto\/SP 14040-904 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Zamarioli","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Anaesthesiology, Medical School (FMRP), University of S\u00e3o Paulo , Av. Bandeirantes, 3900, Ribeir\u00e3o Preto, SP 14049-900 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Consolaro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo , Avenida do Caf\u00e9, s\/n. Ribeir\u00e3o Preto\/SP 14040-904 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia P","family":"Lucisano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo , Avenida do Caf\u00e9, s\/n. Ribeir\u00e3o Preto\/SP 14040-904 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Fernando Neuppmann","family":"Feres","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, University of S\u00e3o Paulo, Department of Orthodontics and Pediatric Dentistry , Professor Lineu Prestes Avenue, 2227. University City, S\u00e3o Paulo, SP 05508-000 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo , Avenida do Caf\u00e9, s\/n. Ribeir\u00e3o Preto\/SP 14040-904 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Nelson-Filho","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Ribeir\u00e3o Preto School of Dentistry, University of S\u00e3o Paulo , Avenida do Caf\u00e9, s\/n. Ribeir\u00e3o Preto\/SP 14040-904 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"key":"2025080204451863300_CIT0001","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jocd.2014.01.005","article-title":"Bone health in children and adolescents with chronic diseases that may affect the skeleton: The 2013 ISCD pediatric official positions","volume":"17","author":"Bianchi","year":"2014","journal-title":"J Clin Densitom"},{"key":"2025080204451863300_CIT0002","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00223-022-01054-z","article-title":"Biochemical markers of musculoskeletal health and aging to be assessed in clinical trials of drugs aiming at the treatment of sarcopenia: consensus paper from an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Acad\u00e9mique de Recherche et d\u2019Exp\u00e9rimentation en Sant\u00e9 (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the epidemiology of musculoskeletal conditions and aging","volume":"112","author":"Ladang","year":"2023","journal-title":"Calcif Tissue Int"},{"key":"2025080204451863300_CIT0003","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s11914-023-00774-x","article-title":"Osteoimmunology in periodontitis and orthodontic tooth movement","volume":"21","author":"Alghamdi","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"2025080204451863300_CIT0004","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41368-021-00125-5","article-title":"Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade","volume":"13","author":"Li","year":"2021","journal-title":"Int J Oral Sci"},{"key":"2025080204451863300_CIT0005","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/ajpa.24825","article-title":"The various meanings and uses of bone \u2018remodeling\u2019 in biological anthropology: a review","volume":"182","author":"Wei","year":"2023","journal-title":"Am J Biol Anthropol."},{"key":"2025080204451863300_CIT0006","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/ejo\/cjac041","article-title":"Periodontal ligament cells derived small extracellular vesicles are involved in orthodontic tooth movement","volume":"44","author":"Zhang","year":"2022","journal-title":"Eur J Orthod"},{"key":"2025080204451863300_CIT0007","doi-asserted-by":"publisher","first-page":"116139","DOI":"10.1016\/j.bone.2021.116139","article-title":"Orthodontic tooth movement alters cementocyte ultrastructure and cellular cementum proteome signature","volume":"153","author":"Lira Dos Santos","year":"2021","journal-title":"Bone"},{"key":"2025080204451863300_CIT0008","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3390\/bioengineering10010086","article-title":"Bone morphogenetic protein 2 promotes bone formation in bone defects in which bone remodeling is suppressed by long-term and high-dose zoledronic acid","volume":"10","author":"Moon","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"2025080204451863300_CIT0009","doi-asserted-by":"publisher","first-page":"106350","DOI":"10.1016\/j.jmbbm.2023.106350","article-title":"Zoledronate reduces loading-induced microdamage in cortical ulna of ovariectomized rats","volume":"150","author":"Ning","year":"2024","journal-title":"J Mech Behav Biomed Mater"},{"key":"2025080204451863300_CIT0010","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/joor.12365","article-title":"The role of orthodontics in the regeneration of the degenerated dentition","volume":"43","author":"Melsen","year":"2016","journal-title":"J Oral Rehabil"},{"key":"2025080204451863300_CIT0011","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1177\/14653125211042891","article-title":"The consequences of living with a severe malocclusion: a review of the literature","volume":"49","author":"Leck","year":"2022","journal-title":"J Orthod"},{"key":"2025080204451863300_CIT0012","doi-asserted-by":"crossref","first-page":"961941","DOI":"10.3389\/fphar.2022.961941","article-title":"How zoledronic acid improves osteoporosis by acting on osteoclasts","volume":"13","author":"Wang","year":"2002","journal-title":"Front Pharmacol"},{"key":"2025080204451863300_CIT0013","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jormas.2020.03.004","article-title":"Bifunctional effect of Zoledronic Acid (ZA) on human mesenchymal stem cells (hMSCs) based on the concentration level","volume":"121","author":"Fliefel","year":"2020","journal-title":"J Stomatol Oral Maxillofac Surg."},{"key":"2025080204451863300_CIT0014","article-title":"Zoledronate","volume-title":"StatPearls","author":"Greear","year":"2024"},{"key":"2025080204451863300_CIT0015","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/jbmr.1543","article-title":"Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo","volume":"27","author":"Roelofs","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2025080204451863300_CIT0016","doi-asserted-by":"publisher","first-page":"103635","DOI":"10.1016\/j.jmbbm.2020.103635","article-title":"A nitrogen-containing bisphosphonate inhibits osteoblast attachment and impairs bone healing in bone-compatible scaffold","volume":"104","author":"Koyama","year":"2020","journal-title":"J Mech Behav Biomed Mater"},{"key":"2025080204451863300_CIT0017","doi-asserted-by":"publisher","first-page":"5578088","DOI":"10.1155\/2021\/5578088","article-title":"Inhibition effect of zoledronate on the osteoclast differentiation of RAW264.7 induced by titanium particles","volume":"2021","author":"Zhao","year":"2021","journal-title":"Biomed Res Int"},{"key":"2025080204451863300_CIT0018","doi-asserted-by":"publisher","first-page":"e35503","DOI":"10.7759\/cureus.35503","article-title":"An Evaluation of the effectiveness of local delivery of Zoledronic Acid in accelerating bone healing after the extraction of mandibular third molars","volume":"15","author":"Ahmed","year":"2023","journal-title":"Cureus."},{"key":"2025080204451863300_CIT0019","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13104-021-05900-5","article-title":"Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid","volume":"15","author":"Li","year":"2022","journal-title":"BMC Res Notes."},{"key":"2025080204451863300_CIT0020","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.mcna.2023.05.022","article-title":"Chronic recurrent multifocal osteomyelitis","volume":"108","author":"Rafferty","year":"2024","journal-title":"Med Clin North Am"},{"key":"2025080204451863300_CIT0021","doi-asserted-by":"publisher","first-page":"629928","DOI":"10.3389\/fbioe.2021.629928","article-title":"Zoledronic acid-loaded hybrid hyaluronic acid\/polyethylene glycol\/nano-hydroxyapatite nanoparticle: novel fabrication and safety verification","volume":"9","author":"Xu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"2025080204451863300_CIT0022","doi-asserted-by":"publisher","first-page":"1172705","DOI":"10.3389\/fphar.2023.1172705","article-title":"Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect","volume":"14","author":"Berg","year":"2023","journal-title":"Front Pharmacol"},{"key":"2025080204451863300_CIT0023","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1177\/154405910708601102","article-title":"Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates","volume":"86","author":"Kimmel","year":"2007","journal-title":"J Dent Res"},{"key":"2025080204451863300_CIT0024","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1152\/japplphysiol.00632.2007","article-title":"Development of a low-dose anti-resorptive drug regimen reveals synergistic suppression of bone formation when coupled with disuse","volume":"104","author":"Lloyd","year":"2008","journal-title":"J Appl Physiol"},{"key":"2025080204451863300_CIT0025","doi-asserted-by":"publisher","first-page":"7672","DOI":"10.1038\/s41598-021-87375-9","article-title":"The effect of high concentration of zoledronic acid on tooth induced movement and its repercussion on root, periodontal ligament, and alveolar bone tissues in rats","volume":"11","author":"de Sousa","year":"2021","journal-title":"Sci Rep"},{"key":"2025080204451863300_CIT0026","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3390\/cells13020147","article-title":"GDF15 Modulates the zoledronic-acid-induced hyperinflammatory mechanoresponse of periodontal ligament fibroblasts","volume":"13","author":"Nitzsche","year":"2024","journal-title":"Cells"},{"key":"2025080204451863300_CIT0027","doi-asserted-by":"publisher","first-page":"257","DOI":"10.15171\/joddd.2017.045","article-title":"Effect of local injection of Zolena, zoledronic acid made in Iran, on orthodontic tooth movement and root and bone resorption in rats","volume":"11","author":"Seifi","year":"2017","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"2025080204451863300_CIT0028","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1590\/S1806-83242013000300005","article-title":"Radiodensitometric and DXA analyses for the measurement of bone mineral density after systemic alendronate therapy","volume":"27","author":"Lucisano","year":"2013","journal-title":"Braz Oral Res"},{"key":"2025080204451863300_CIT0029","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1177\/0022034509346230","article-title":"CCR5 down-regulates osteoclast function in orthodontic tooth movement","volume":"88","author":"Andrade","year":"2009","journal-title":"J Dent Res"},{"key":"2025080204451863300_CIT0030","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1016\/j.jbiomech.2012.09.006","article-title":"Experimental model of tooth movement in mice: a standardized protocol for studying bone remodeling under compression and tensile strains","volume":"45","author":"Taddei","year":"2012","journal-title":"J Biomech"},{"key":"2025080204451863300_CIT0031","doi-asserted-by":"publisher","first-page":"105324","DOI":"10.1016\/j.archoralbio.2021.105324","article-title":"Probiotic Bifidobacterium animalis subsp. lactis consumption slows down orthodontic tooth movement in mice","volume":"134","author":"Duffles","year":"2022","journal-title":"Arch Oral Biol"},{"key":"2025080204451863300_CIT0032","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.csbj.2021.01.022","article-title":"QuPath: the global impact of an open source digital pathology system","volume":"19","author":"Humphries","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"2025080204451863300_CIT0033","doi-asserted-by":"publisher","first-page":"e4459","DOI":"10.21769\/BioProtoc.4459","article-title":"Automated quantification of multiple cell types in fluorescently labeled whole mouse brain sections using QuPath","volume":"12","author":"Courtney","year":"2022","journal-title":"Bio Protoc"},{"key":"2025080204451863300_CIT0034","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.5005\/jp-journals-10024-2698","article-title":"Effect of vitamin d on canine distalization and alveolar bone density using multi-slice spiral CT: a randomized controlled trial","volume":"20","author":"Varughese","year":"2019","journal-title":"J Contemp Dent Pract"},{"key":"2025080204451863300_CIT0035","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1016\/j.ajodo.2021.11.014","article-title":"Efficacy of the systemic co-administration of vitamin D3 in reversing the inhibitory effects of sodium alendronate on orthodontic tooth movement: a preliminary experimental animal study","volume":"162","author":"Moradinejad","year":"2022","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025080204451863300_CIT0036","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1007\/s10266-023-00890-1","article-title":"Correlation of salivary cytokine IL-17A and 1,25 dihydroxycholecalciferol in patients undergoing orthodontic treatment","volume":"112","author":"Sagar","year":"2024","journal-title":"Odontology"},{"key":"2025080204451863300_CIT0037","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/j.1445-5994.2007.01580.x","article-title":"Risk factors for symptomatic hypocalcaemia complicating treatment with zoledronic acid","volume":"38","author":"Chennuru","year":"2008","journal-title":"Intern Med J"},{"key":"2025080204451863300_CIT0038","doi-asserted-by":"publisher","first-page":"10409","DOI":"10.1096\/fj.201900484R","article-title":"Role of intracellular Ca2+-based mechanotransduction of human periodontal ligament fibroblasts","volume":"33","author":"Ei Hsu Hlaing","year":"2019","journal-title":"FASEB J"},{"key":"2025080204451863300_CIT0039","doi-asserted-by":"publisher","first-page":"766","DOI":"10.2319\/111312-869.1","article-title":"The effect of bone morphometric changes on orthodontic tooth movement in an osteoporotic animal model","volume":"83","author":"Hashimoto","year":"2013","journal-title":"Angle Orthod"},{"key":"2025080204451863300_CIT0040","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.sdentj.2020.03.003","article-title":"The intrasulcular application effect of bisphosphonate hydrogel toward osteoclast activity and relapse movement","volume":"33","author":"Utari","year":"2021","journal-title":"Saudi Dent J."},{"key":"2025080204451863300_CIT0041","doi-asserted-by":"publisher","first-page":"e339","DOI":"10.4317\/medoral.22883","article-title":"Effects of zoledronic acid and dexamethasone on early phases of socket healing after tooth extraction in rats: a preliminary macroscopic and microscopic quantitative study","volume":"24","author":"Mergoni","year":"2019","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"2025080204451863300_CIT0042","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/s00223-021-00890-9","article-title":"Zoledronic acid deteriorates soft and hard tissue healing of murine tooth extraction sockets in a dose-dependent manner","volume":"110","author":"Kozutsumi","year":"2022","journal-title":"Calcif Tissue Int"},{"key":"2025080204451863300_CIT0043","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/ocr.12192","article-title":"Zoledronic acid and alendronate sodium and the implications in orthodontic movement","volume":"20","author":"Franzoni","year":"2017","journal-title":"Orthod Craniofac Res"},{"key":"2025080204451863300_CIT0044","first-page":"248 (CED-IADR-2024)","article-title":"Zoledronic acid modulate inflammatory response induced by orthodontic force","volume":"103","author":"Bergamo","year":"2024","journal-title":"J Dent Res"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/47\/4\/cjaf032\/63923795\/cjaf032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/47\/4\/cjaf032\/63923795\/cjaf032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T08:45:24Z","timestamp":1754124324000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/doi\/10.1093\/ejo\/cjaf032\/8221371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,6,12]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjaf032","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8]]},"published":{"date-parts":[[2025,6,12]]},"article-number":"cjaf032"}}