{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:23:32Z","timestamp":1760747012688,"version":"build-2065373602"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to assess the frequency of distoangulation of mandibular second premolars (MnP2) in individuals with complete unilateral cleft lip and palate, the angular changes of distoangulated MnP2 from the mixed to the permanent dentition, the clinical outcomes after the follow-up period and the frequency of other associated dental anomalies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The distoangulation group (DA) was composed of 37 patients (mean age 9.29, SD = 1.24 years, 15 females, 22 males) with distoangulation of MnP2. The control group (CG) was composed of 37 patients (mean age 9.9 years, SD = 1.13, 13 females, 24 males) without distoangulation of MnP2. Digital panoramic radiographs taken in the mixed dentition (T1) and early permanent dentition (T2) were analyzed in both groups. Longitudinal angular changes, the degree of root formation, second premolar depth, and the frequency of associated dental anomalies were analyzed. Intergroup comparison was performed with paired and independent t tests and \u03c7\u00b2 test (p &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The prevalence of MnP2 distoangulation in the mixed dentition was 18.5%. The DA showed a smaller initial distal angle (\u03b8 = 56.45\u00b0 \u00b1 6.72) compared to the CG (78.24\u00b0 \u00b1 6.09). The most common clinical outcome was the uprighting and spontaneous eruption of the MnP2 observed in 80.0% of the sample. MnP2 distoangulation was significantly associated with deciduous molar infraocclusion, agenesis of maxillary second premolar and ectopic eruption of maxillary first permanent molar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The frequency of MnP2 distoangulation among individuals with UCLP was 18.5%, with favorable spontaneous uprighting and eruption observed in most cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejo\/cjaf077","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:34:27Z","timestamp":1760708067000},"source":"Crossref","is-referenced-by-count":0,"title":["Distoangulation of mandibular second premolars in individuals with complete unilateral cleft lip and palate: a cohort longitudinal assessment"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1649-6007","authenticated-orcid":false,"given":"Isadora","family":"Medeiros","sequence":"first","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies (HRAC), University of Sao Paulo , Silvio Marchione, 3-20, Bauru, SP, 17012-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-4064","authenticated-orcid":false,"given":"Beatriz","family":"Quevedo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Bauru Dental School, University of S\u00e3o Paulo , Alameda Dr. Oct\u00e1vio Pinheiro Brisolla, Bauru, SP, 17012-901 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-612X","authenticated-orcid":false,"given":"Claudia Resende","family":"Leal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hospital for Rehabilitation of Craniofacial Anomalies (HRAC), University of Sao Paulo , Silvio Marchione, 3-20, Bauru, SP, 17012-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-796X","authenticated-orcid":false,"given":"Gisele da Silva","family":"Dalben","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Hospital for Rehabilitation of Craniofacial Anomalies (HRAC), University of Sao Paulo , Silvio Marchione, 3-20, Bauru, SP, 17012-900 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-1620","authenticated-orcid":false,"given":"Daniela","family":"Garib","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies (HRAC), University of Sao Paulo , Silvio Marchione, 3-20, Bauru, SP, 17012-900 ,","place":["Brazil"]},{"name":"Department of Orthodontics, Bauru Dental School, University of S\u00e3o Paulo , Alameda Dr. Oct\u00e1vio Pinheiro Brisolla, Bauru, SP, 17012-901 ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"2025101709342172900_cjaf077-B1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1597\/07-239.1","article-title":"Treatment of dental anomalies in children with complete unilateral cleft lip and palate at SickKids hospital, Toronto","volume":"46","author":"Cassolato","year":"2009","journal-title":"Cleft Palate Craniofac J"},{"key":"2025101709342172900_cjaf077-B2","doi-asserted-by":"publisher","first-page":"SUPPL1344-63","DOI":"10.1177\/00220345630420061001","article-title":"Third molar polymorphism and its significance to dental genetics","volume":"42","author":"Garn","year":"1963","journal-title":"J Dent Res"},{"key":"2025101709342172900_cjaf077-B3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1043\/0003-3219(1982)052&lt;0011:EDMOTM&gt;2.0.CO;2","article-title":"Extreme distal migration of the mandibular second bicuspid. A variant of eruption","volume":"52","author":"Matteson","year":"1982","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B4","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1600-0722.1980.tb01240.x","article-title":"Hypodontia of permanent teeth in Danish schoolchildren","volume":"88","author":"Rolling","year":"1980","journal-title":"Scand J Dent Res"},{"key":"2025101709342172900_cjaf077-B5","first-page":"107","article-title":"A survey of congenitally missing teeth, excluding third molars, in 6000 orthodontic patients","volume":"17","author":"Rose","year":"1966","journal-title":"Dent Pract Dent Rec"},{"key":"2025101709342172900_cjaf077-B6","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ajodo.2008.09.036","article-title":"Distally displaced premolars: a dental anomaly associated with palatally displaced canines","volume":"138","author":"Baccetti","year":"2010","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025101709342172900_cjaf077-B7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/ejo\/cjp156","article-title":"Dental anomalies in individuals with cleft lip and\/or palate","volume":"32","author":"Akcam","year":"2010","journal-title":"Eur J Orthod"},{"key":"2025101709342172900_cjaf077-B8","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.12659\/MSM.897957","article-title":"Radiographic study of the prevalence and distribution of hypodontia associated with unilateral and bilateral clef lip and palate in a Hungarian population","volume":"22","author":"Berniczei-Royko","year":"2016","journal-title":"Med Sci Monit"},{"key":"2025101709342172900_cjaf077-B9","first-page":"89","article-title":"Diagnosis and treatment planning for unerupted premolars","volume":"16","author":"Burch","year":"1994","journal-title":"Pediatr Dent"},{"key":"2025101709342172900_cjaf077-B10","first-page":"262","article-title":"Studies of permanent tooth anomalies in 7,886 Canadian individuals. I: impacted teeth","volume":"44","author":"Shah","year":"1978","journal-title":"Dent J"},{"key":"2025101709342172900_cjaf077-B11","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-0722.1973.tb01489.x","article-title":"The prevalence of malocclusion in Swedish schoolchildren","volume":"81","author":"Thilander","year":"1973","journal-title":"Scand J Dent Res"},{"key":"2025101709342172900_cjaf077-B12","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/ejo\/cjad038","article-title":"Mandibular second premolar distoangulation: a longitudinal follow-up from the mixed to the permanent dentition","volume":"45","author":"Quevedo","year":"2023","journal-title":"Eur J Orthod"},{"key":"2025101709342172900_cjaf077-B13","doi-asserted-by":"publisher","first-page":"796","DOI":"10.2319\/081808-435.1","article-title":"Malposition of unerupted mandibular second premolar in children with palatally displaced canines","volume":"79","author":"Shalish","year":"2009","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1067\/mod.2002.120399","article-title":"Malposition of unerupted mandibular second premolar associated with agenesis of its antimere","volume":"121","author":"Shalish","year":"2002","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025101709342172900_cjaf077-B15","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.ajodo.2023.05.029","article-title":"Mesiodistal angulation and developmental stages of unerupted mandibular second premolars in nonsyndromic oligodontia","volume":"164","author":"Arai","year":"2023","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025101709342172900_cjaf077-B16","doi-asserted-by":"publisher","first-page":"959","DOI":"10.2319\/012012-49.1","article-title":"Is missing maxillary lateral incisor in complete cleft lip and palate a product of genetics or local environment?","volume":"82","author":"Dentino","year":"2012","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000337464","article-title":"Epidemiology of oral clefts 2012: an international perspective","volume":"16","author":"Mossey","year":"2012","journal-title":"Front Oral Biol"},{"key":"2025101709342172900_cjaf077-B18","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/ipd.13252","article-title":"Association between molar-incisor hypomineralisation and dental anomalies","volume":"35","author":"Fernandes","year":"2025","journal-title":"Int J Paediatr Dent"},{"key":"2025101709342172900_cjaf077-B19","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1597\/1545-1569_2003_040_0172_daotpl_2.0.co_2","article-title":"Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate","volume":"40","author":"Lourenco Ribeiro","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"key":"2025101709342172900_cjaf077-B20","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1590\/S1678-77572005000400021","article-title":"Associated dental anomalies: case report","volume":"13","author":"Garib","year":"2005","journal-title":"J Appl Oral Sci"},{"key":"2025101709342172900_cjaf077-B21","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.2319\/052106-207","article-title":"Malposition of unerupted mandibular second premolar in children with cleft lip and palate","volume":"77","author":"Shalish","year":"2007","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B22","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1043\/0003-3219(2004)074&lt;0332:ACATRI&gt;2.0.CO;2","article-title":"Angular changes and their rates in concurrence to developmental stages of the mandibular second premolar","volume":"74","author":"Wasserstein","year":"2004","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B23","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.coms.2015.04.007","article-title":"Surgical treatment of impacted canines: what the orthodontist would like the surgeon to know","volume":"27","author":"Becker","year":"2015","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"2025101709342172900_cjaf077-B24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s40368-019-00459-z","article-title":"Ectopic eruption of the second premolar: an analysis of four different treatment approaches","volume":"21","author":"Ismail","year":"2020","journal-title":"Eur Arch Paediatr Dent"},{"key":"2025101709342172900_cjaf077-B25","first-page":"211","article-title":"A new system of dental age assessment","volume":"45","author":"Demirjian","year":"1973","journal-title":"Hum Biol"},{"key":"2025101709342172900_cjaf077-B26","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1590\/1678-775720150535","article-title":"Risk of developing palatally displaced canines in patients with early detectable dental anomalies: a retrospective cohort study","volume":"24","author":"Garib","year":"2016","journal-title":"J Appl Oral Sci"},{"key":"2025101709342172900_cjaf077-B27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1080\/00016357.2016.1273385","article-title":"Dental anomaly patterns associated with tooth agenesis","volume":"75","author":"Choi","year":"2017","journal-title":"Acta Odontol Scand"},{"key":"2025101709342172900_cjaf077-B28","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.2319\/0003-3219-079.005.1015","article-title":"Dental anomaly patterns (DAP). A new way to look at malocclusion","volume":"79","author":"Peck","year":"2009","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B29","doi-asserted-by":"publisher","first-page":"591","DOI":"10.31729\/jnma.5149","article-title":"Prevalence of dental anomalies in the patient with cleft lip and palate visiting a tertiary care hospital","volume":"58","author":"Pradhan","year":"2020","journal-title":"JNMA J Nepal Med Assoc"},{"key":"2025101709342172900_cjaf077-B30","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.archoralbio.2012.12.007","article-title":"Tooth agenesis patterns in unilateral cleft lip and palate in humans","volume":"58","author":"Bartzela","year":"2013","journal-title":"Arch Oral Biol"},{"key":"2025101709342172900_cjaf077-B31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1067\/mod.2003.3","article-title":"Panoramic radiographs: a tool for investigating skeletal pattern","volume":"123","author":"Akcam","year":"2003","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025101709342172900_cjaf077-B32","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.fsc.2014.07.002","article-title":"Cleft lip and palate","volume":"22","author":"Crockett","year":"2014","journal-title":"Facial Plast Surg Clin North Am"},{"key":"2025101709342172900_cjaf077-B33","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.jcms.2015.04.015","article-title":"A comparative cephalometric study for adult operated cleft palate and unoperated cleft palate patients","volume":"43","author":"Ye","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"2025101709342172900_cjaf077-B34","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1067\/mod.2002.119435","article-title":"The accuracy of 4 panoramic units in the projection of mesiodistal tooth angulations","volume":"121","author":"McKee","year":"2002","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2025101709342172900_cjaf077-B35","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/ejo\/24.1.43","article-title":"Accuracy of linear and angular measurements on panoramic radiographs taken at various positions in vitro","volume":"24","author":"Stramotas","year":"2002","journal-title":"Eur J Orthod"},{"key":"2025101709342172900_cjaf077-B36","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1043\/0003-3219(2001)071&lt;0442:TEOVAH&gt;2.0.CO;2","article-title":"The effect of vertical and horizontal head positioning in panoramic radiography on mesiodistal tooth angulations","volume":"71","author":"McKee","year":"2001","journal-title":"Angle Orthod"},{"key":"2025101709342172900_cjaf077-B37","first-page":"61","article-title":"Developmental changes of mandibular permanent canines and premolars in early mixed dentition","volume":"26","author":"Tsai","year":"2001","journal-title":"J Clin Pediatr Dent"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/47\/6\/cjaf077\/64736735\/cjaf077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/47\/6\/cjaf077\/64736735\/cjaf077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:34:29Z","timestamp":1760708069000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/doi\/10.1093\/ejo\/cjaf077\/8292198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,10,16]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjaf077","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,10,16]]},"article-number":"cjaf077"}}