{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T18:08:19Z","timestamp":1779473299681,"version":"3.53.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To compare the diagnostic accuracy of CBCT images acquired with different imaging protocols for detecting tooth ankylosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty extracted permanent teeth (20 single-rooted, 10 three-rooted) were prepared; ankylosis was simulated in 20 by selectively removing Teflon from roots previously coated to mimic the periodontal ligament. Samples were embedded in stone plaster and imaged using 4 protocols on 2 CBCT units. CBCT images were primarily evaluated by a blinded radiologist (present\/absent). Micro-CT was performed on 20% of specimens to verify the model. Agreement and accuracy metrics (Fleiss\/Cohen \u03ba, sensitivity, specificity, PPV, NPV) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Protocol 2 (0.25 mm voxel) showed the most favorable performance (\u03ba = 0.113; sensitivity 71.4%; PPV 52.6%; NPV 60%). Protocol 3 (0.35\u2005mm voxel) performed worst (\u03ba = \u22120.104; sensitivity 53.8%; PPV 43.8%; NPV 45.5%). Except for Protocol 3, sensitivity was high (\u226571.4%) while specificity remained low (35.7%\u201342.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations<\/jats:title>\n                    <jats:p>The study has its own limits. Different imaging protocols using in clinical practice to detect ankylosis can be investigated as well to provide different approaches assessing ankylosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CBCT demonstrated high sensitivity but low specificity for ankylosis detection, indicating a propensity for false positives. Smaller voxel sizes (0.25\u20130.30\u2005mm) improved detection, whereas 0.35\u2005mm was least reliable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejo\/cjag043","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:21:08Z","timestamp":1779103268000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of imaging protocols for detecting tooth ankylosis using different CBCT devices: an\n                    <i>in vitro<\/i>\n                    study"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7399-1074","authenticated-orcid":false,"given":"\u015eelale","family":"\u00d6zel","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Alt\u0131nba\u015f University , Zuhuratbaba mah. \u0130ncirli cd. 11\/A Bak\u0131rk\u00f6y, \u0130stanbul 34158 ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-0393","authenticated-orcid":false,"given":"Taha Emre","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Recep Tayyip Erdogan University , \u0130slampa\u015fa, Menderes Blv. no:612, Rize Merkez 53020 ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-5928","authenticated-orcid":false,"given":"Samed","family":"\u015eat\u0131r","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Karamanoglu Mehmetbey University , \u00dcniversite, Karaman Merkez 70200 ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"2026052213565571400_cjag043-B1","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ajodo.2013.03.015","article-title":"Establishing the diagnostic criteria for eruption disorders based on genetic and clinical data","volume":"144","author":"Rhoads","year":"2013","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2026052213565571400_cjag043-B2","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40510-025-00570-6","article-title":"Permanent first molar eruption failure in children: leading signs for early diagnosis","volume":"26","author":"Grippaudo","year":"2025","journal-title":"Prog Orthod"},{"key":"2026052213565571400_cjag043-B3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/ocr.12160","article-title":"In silico and functional evaluation of PTH 1R mutations found in patients with primary failure of eruption (PFE)","volume":"20","author":"Hendricks","year":"2017","journal-title":"Orthod Craniofac Res"},{"key":"2026052213565571400_cjag043-B4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40510-021-00387-z","article-title":"Validating clinical characteristics of primary failure of eruption (PFE) associated with PTH1R variants","volume":"22","author":"Grippaudo","year":"2021","journal-title":"Prog Orthod"},{"key":"2026052213565571400_cjag043-B5","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4103\/jiaomr.jiaomr_148_25","article-title":"Identification of a novel PTH1R mutation in primary failure of eruption: a case report and therapeutic perspectives","volume":"37","author":"Darjee","year":"2025","journal-title":"J Indian Academy Oral Med Radio"},{"key":"2026052213565571400_cjag043-B6","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jobcr.2023.01.001","article-title":"Primary failure of eruption: from molecular diagnosis to therapeutic management","volume":"13","author":"Wagner","year":"2023","journal-title":"J Oral Biol Craniofac Res"},{"key":"2026052213565571400_cjag043-B7","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jdsr.2022.08.002","article-title":"Primary failure of tooth eruption: etiology and management","volume":"58","author":"Yamaguchi","year":"2022","journal-title":"Jpn Dent Sci Rev"},{"key":"2026052213565571400_cjag043-B8","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1177\/0022034520934732","article-title":"Role of PTH1R signaling in Prx1 + mesenchymal progenitors during eruption","volume":"99","author":"Cui","year":"2020","journal-title":"J Dent Res"},{"key":"2026052213565571400_cjag043-B9","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/edt.12520","article-title":"Risk of ankylosis of 400 avulsed and replanted human teeth in relation to length of dry storage: a re-evaluation of a long-term clinical study","volume":"36","author":"Lauridsen","year":"2020","journal-title":"Dent Traumatol"},{"key":"2026052213565571400_cjag043-B10","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/aej.12416","article-title":"The accuracy of periapical radiography and cone beam computed tomographycin measuring periodontal ligament space: ex vivo comparative micro-CT study","volume":"46","author":"Tayman","year":"2020","journal-title":"Aust Endod J"},{"key":"2026052213565571400_cjag043-B11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/odi.13249","article-title":"A threedimensional analysis of primary failure of eruption in humans and mice","volume":"26","author":"Tokavanich","year":"2020","journal-title":"Oral Dis"},{"key":"2026052213565571400_cjag043-B12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/ejo\/cjx063","article-title":"Diagnosis of tooth ankylosis using panoramic views, cone beam computed tomography, and histological data: a retrospective observational case series study","volume":"40","author":"Ducommun","year":"2018","journal-title":"Eur J Orthod"},{"key":"2026052213565571400_cjag043-B13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.oooo.2022.08.007","article-title":"Is the efficacy of cone beam computed tomography in the diagnosis of tooth ankylosis influenced by dose reduction protocols?","volume":"135","author":"Martins","year":"2023","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2026052213565571400_cjag043-B14","doi-asserted-by":"publisher","first-page":"61","DOI":"10.5624\/isd.20220186","article-title":"A novel method of objectively detecting tooth ankylosis using cone-beam computed tomography: a laboratory study","volume":"53","author":"Martins","year":"2023","journal-title":"Imaging Sci Dent"},{"key":"2026052213565571400_cjag043-B15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.5624\/isd.2018.48.2.79","article-title":"Comparison of conventional imaging techniques and CBCT for periodontal evaluation: a systematic review","volume":"48","author":"Choi","year":"2018","journal-title":"Imaging Sci Dent"},{"key":"2026052213565571400_cjag043-B16","doi-asserted-by":"publisher","DOI":"10.58600\/eurjther2763","article-title":"Comparison of play dough and bread dough with ballistic gel as soft tissue simulator: an ex-vivo study with sheep\u2019s head as the gold standard","author":"\u00c7imen","year":"2025","journal-title":"Eur J Ther"},{"key":"2026052213565571400_cjag043-B17","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-16641-0","volume-title":"Micro-computed Tomography (Micro-CT) in Medicine and Engineering","author":"Orhan","year":"2020"},{"key":"2026052213565571400_cjag043-B18","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.oooo.2020.08.030","article-title":"Pixel gray measurement for the diagnosis of dental ankylosis in cone beam computed tomography images","volume":"131","author":"Rege","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"2026052213565571400_cjag043-B19","doi-asserted-by":"publisher","first-page":"e64963","DOI":"10.2196\/64963","article-title":"Comparing diagnostic accuracy of clinical professionals and large language models: systematic review and meta-analysis","volume":"13","author":"Shan","year":"2025","journal-title":"JMIR Med Inform"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/48\/3\/cjag043\/68370448\/cjag043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/48\/3\/cjag043\/68370448\/cjag043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T17:57:03Z","timestamp":1779472623000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/doi\/10.1093\/ejo\/cjag043\/8690901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjag043","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,4,3]]},"article-number":"cjag043"}}