{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:59:36Z","timestamp":1781168376084,"version":"3.54.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Operational Healthcare Committee","award":["VGFOUREG-967125"],"award-info":[{"award-number":["VGFOUREG-967125"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Extraction of mandibular primary second molars in patients with congenitally missing second premolars may influence oral health\u2013related quality of life (OHRQoL), yet this has not been previously investigated.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess the impact of mandibular primary second molar extraction on OHRQoL compared with an age- and gender-matched control group without dental agenesis.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective, randomized, longitudinal split-mouth study.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients were recruited from nine public dental clinics in the Skaraborg region, Sweden (2017\u20132020) with bilateral congenitally missing second mandibular premolars. Each mandibular side was randomly assigned to extraction or hemisection. At the 4-year follow-up, the intervention group underwent a clinical examination and completed the Child Perceptions Questionnaire (CPQ11\u201314) along with a treatment recall and perception questionnaire, whereas the control group underwent a clinical examination and completed the CPQ11\u201314.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study included 80 patients, divided equally between the intervention group (n = 40) and the control group (n = 40). There was no significant difference in total CPQ scores between the intervention group (mean 8.5, SD 5.6) and the control group (mean 6.9, SD 5.6; P = 0.218), nor were any differences observed between sexes. The intervention group scored significantly higher in emotional (P = 0.018) and social well-being (P = 0.045). Hemisection was recalled as more painful than conventional extraction (P &lt; 0.001). Despite 65% reported awareness of residual spaces, 82.5% were not interested in further treatment.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Extraction of mandibular primary second molars in patients with congenitally missing second premolars did not adversely affect overall OHRQoL 4 years post-treatment. Hemisection was recalled as more painful than conventional extraction. Most patients were satisfied without additional treatment, indicating good long-term acceptance of residual spaces following interceptive extraction.<\/jats:p>\n <\/jats:sec>\n \n Trial registration<\/jats:title>\n The trial was registered with https:\/\/www.researchweb.org\/is\/sverige, registration number: 967125.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ejo\/cjag048","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:46:46Z","timestamp":1779450406000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral health\u2013related quality of life after early extraction of primary second molars in children with congenitally missing second premolars: a randomized controlled trial with matched controls"],"prefix":"10.1093","volume":"48","author":[{"given":"Julia","family":"Naoumova","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg , Box 450, 405 30 Gothenburg ,","place":["Sweden"]},{"name":"Public Dental Service, University Clinic of Orthodontics, 413 90 Gothenburg , Region V\u00e4stra G\u00f6taland ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker","family":"Nawaia","sequence":"additional","affiliation":[{"name":"Public Dental Service, Clinic of Orthodontics, 541 30 Sk\u00f6vde, Region V\u00e4stra G\u00f6taland ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Krekmanova","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry, Institute of Odontology, Sahlgrenska Academy , University of Gothenburg, Box 450, 405 30 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"2026061104264261400_cjag048-B1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/ejo\/cji027","article-title":"Hypodontia in orthodontically treated children","volume":"27","author":"Fekonja","year":"2005","journal-title":"Eur J Orthod"},{"key":"2026061104264261400_cjag048-B2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-0722.1973.tb01489.x","article-title":"The prevalence of malocclusion in Swedish schoolchildren","volume":"81","author":"Thilander","year":"1973","journal-title":"Scand J Dent Res"},{"key":"2026061104264261400_cjag048-B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0722.1971.tb01986.x","article-title":"Aplasia, supernumerary teeth and fused teeth in the primary dentition. 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