{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:47:07Z","timestamp":1791888427046,"version":"4.3.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Over the past 40 years, randomized trials have become the mainstay of evidence-based orthodontics.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n This paper represents the content of the Sheldon Friel lecture presented in 2026 at the Congress of the European Orthodontic Society. I outline the value of randomized trials and revisit the findings of some of the main studies I have completed. We must also consider the development of patient-relevant outcomes and core outcome sets. While we recognize the value of trials, we must also recognize that evidence-based care is undermined by claims from the orthodontic fringe.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Tension currently exists between the evidence-based orthodontic approach and the low-quality evidence provided by the orthodontic fringe. This paper provides an overview of these two views. The solution to this dilemma lies in carrying out high-level research and making the findings relevant and understandable to our patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ejo\/cjag071","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:02:43Z","timestamp":1791885763000},"source":"Crossref","is-referenced-by-count":0,"title":["Sheldon Friel lecture 2026. Trials, quackery and social media: was it all a waste of time"],"prefix":"10.1093","volume":"48","author":[{"given":"Kevin","family":"OBrien","sequence":"first","affiliation":[{"name":"Faculty of Biology, Medicine and Health, University of Manchester , Oxford Road, Manchester M19 5PL ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"2026101306023514500_cjag071-B1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1093\/ejo\/12.4.380","article-title":"A clinical trial of aligning archwires","volume":"12","author":"O'Brien","year":"1990","journal-title":"Eur J Orthod"},{"key":"2026101306023514500_cjag071-B2","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.ajodo.2007.10.042","article-title":"Early treatment for class II division 1 malocclusion with the twin-block appliance: a multi-center, randomized, controlled trial","volume":"135","author":"O'Brien","year":"2009","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2026101306023514500_cjag071-B3","doi-asserted-by":"publisher","first-page":"cjaf083","DOI":"10.1093\/ejo\/cjaf083","article-title":"A systematic review considering the risk of bias in orthodontic RCTs over 55 years","volume":"47","author":"Petr\u00e9n","year":"2025","journal-title":"Eur J Orthod"},{"key":"2026101306023514500_cjag071-B4"},{"key":"2026101306023514500_cjag071-B5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ajodo.2014.03.020","article-title":"Et al effectiveness of 3 methods of anchorage reinforcement for maximum anchorage in adolescents: a 3-arm multicenter randomized clinical trial","volume":"146","author":"Sandler","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2026101306023514500_cjag071-B6","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1111\/idj.12294","article-title":"A new definition for oral health developed by the FDI World Dental Federation opens the door to a universal definition of oral health","volume":"66","author":"Glick","year":"2016","journal-title":"Int Dent J"},{"key":"2026101306023514500_cjag071-B7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ajodo.2014.05.022","article-title":"Do orthodontic research outcomes reflect patient values? A systematic review of randomized controlled trials involving children","volume":"146","author":"Tsichlaki","year":"2014","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"2026101306023514500_cjag071-B8","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.ajodo.2020.05.010","article-title":"Development of a core outcome set for use in routine orthodontic clinical trials","volume":"158","author":"Tsichlaki","year":"2020","journal-title":"Am J Orthod Dentofacial Orthop"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/48\/6\/cjag071\/71900210\/cjag071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejo\/article-pdf\/48\/6\/cjag071\/71900210\/cjag071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:02:44Z","timestamp":1791885764000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/doi\/10.1093\/ejo\/cjag071\/8913473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjag071","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,12]]},"published":{"date-parts":[[2026,10,6]]},"article-number":"cjag071"}}