{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:43:14Z","timestamp":1780357394531,"version":"3.54.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1093\/ejo\/cjq079","type":"journal-article","created":{"date-parts":[[2011,1,15]],"date-time":"2011-01-15T01:14:58Z","timestamp":1295054098000},"page":"318-324","source":"Crossref","is-referenced-by-count":108,"title":["A systematic review of the efficacy of oral appliance design in the management of obstructive sleep apnoea"],"prefix":"10.1093","volume":"33","author":[{"given":"Anika","family":"Ahrens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colman","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"H\u00e4gg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,1,13]]},"reference":[{"key":"key\n\t\t\t\t20170614075205_bib1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1164\/ajrccm.151.5.7735600","article-title":"Snoring and sleep apnea. A population study in Australian men","volume":"151","author":"Bearpark","year":"1995","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1164\/ajrccm.157.1.9706079","article-title":"Effects of age on sleep apnea in men: I. Prevalence and severity","volume":"157","author":"Bixler","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11325-005-0003-4","article-title":"Prospective evaluation of an oral appliance in the treatment of obstructive sleep apnea syndrome","volume":"9","author":"Blanco","year":"2005","journal-title":"Sleep and Breathing"},{"key":"key\n\t\t\t\t20170614075205_bib4","volume-title":"Statistical questions in evidence based medicine","author":"Bland","year":"2004"},{"key":"key\n\t\t\t\t20170614075205_bib5","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1164\/ajrccm.162.1.9908112","article-title":"A randomized, controlled crossover trial of two oral appliances for sleep apnea treatment","volume":"162","author":"Bloch","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib6","article-title":"Surgery for obstructive sleep apnoea","author":"Bridgman","year":"2000","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"key\n\t\t\t\t20170614075205_bib7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1378\/chest.06-2038","article-title":"Dental appliance treatment for obstructive sleep apnea","volume":"132","author":"Chan","year":"2007","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170614075205_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1586\/17434440.2.6.749","article-title":"Medical devices for the diagnosis and treatment of obstructive sleep apnea","volume":"2","author":"Cistulli","year":"2005","journal-title":"Expert Review of Medical Devices"},{"key":"key\n\t\t\t\t20170614075205_bib9","first-page":"26","article-title":"Understanding obstructive sleep apnoea","volume":"99","author":"Davey","year":"2003","journal-title":"Nursing Times"},{"key":"key\n\t\t\t\t20170614075205_bib10","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/sleep\/25.5.505","article-title":"Effects of mandibular posture on obstructive sleep apnea severity and the temporomandibular joint in patients fitted with an oral appliance","volume":"25","author":"de Almeida","year":"2002","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170614075205_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2753.2006.00793.x","article-title":"An analysis of the evidence-practice continuum: is surgery for obstructive sleep apnea contraindicated?","volume":"13","author":"Elshaug","year":"2007","journal-title":"Journal of Evaluation in Clinical Practice"},{"key":"key\n\t\t\t\t20170614075205_bib12","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1378\/chest.109.6.1470","article-title":"Self-reported use of CPAP and benefits of CPAP therapy: a patient survey","volume":"109","author":"Engleman","year":"1996","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170614075205_bib13","article-title":"Lung health in Europe\u2014facts and figures","author":"European Respiratory Society and European Lung Foundation","year":"2003"},{"key":"key\n\t\t\t\t20170614075205_bib14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1378\/chest.121.3.674","article-title":"Treatment of obstructive sleep apnea: no longer just a lot of hot air","volume":"121","author":"Eveloff","year":"2002","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170614075205_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.sleep.2008.03.011","article-title":"Efficacy of two mandibular advancement appliances in the management of snoring and mild-moderate sleep apnea: a cross-over randomized study","volume":"10","author":"Gauthier","year":"2009","journal-title":"Sleep Medicine"},{"issue":"Issue 3","key":"key\n\t\t\t\t20170614075205_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001106.pub2","article-title":"Continuous positive airways pressure for obstructive sleep apnea in adults","author":"Giles","year":"2006","journal-title":"Cochrane Database Systematic Review"},{"key":"key\n\t\t\t\t20170614075205_bib17","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1164\/rccm.200203-208OC","article-title":"Oral appliance therapy improves symptoms in obstructive sleep apnea: a randomized, controlled trial","volume":"166","author":"Gotsopoulos","year":"2002","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0889-5406(97)70293-2","article-title":"Comparison of two dental devices for treatment of obstructive sleep apnea syndrome (OSA)","volume":"111","author":"Hans","year":"1997","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"key\n\t\t\t\t20170614075205_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3109\/00016489009122528","article-title":"Driving vigilance simulator test","volume":"110","author":"Haraldsson","year":"1990","journal-title":"Acta Oto-Laryngologica"},{"key":"key\n\t\t\t\t20170614075205_bib20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1164\/ajrccm.161.2.9903079","article-title":"An oral elastic mandibular advancement device for obstructive sleep apnea","volume":"161","author":"Henke","year":"2000","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/154411130401500303","article-title":"Efficacy and co-morbidity of oral appliances in the treatment of obstructive sleep apnea-hypopnea: a systematic review","volume":"15","author":"Hoekema","year":"2004","journal-title":"Critical Reviews in Oral Biology and Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11325-006-0084-8","article-title":"Review of oral appliances for treatment of sleep-disordered breathing","volume":"11","author":"Hoffstein","year":"2007","journal-title":"Sleep and Breathing"},{"key":"key\n\t\t\t\t20170614075205_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1378\/chest.125.1.127","article-title":"A community study of sleep-disordered breathing in middle-aged Chinese women in Hong Kong: prevalence and gender differences","volume":"125","author":"Ip","year":"2004","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170614075205_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/1753465808098225","article-title":"Pharmacotherapy of obstructive sleep apnea","volume":"2","author":"Jayaraman","year":"2008","journal-title":"Therapeutic Advances in Respiratory Diseases"},{"key":"key\n\t\t\t\t20170614075205_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/ejo\/24.3.251","article-title":"Mandibular advancement appliances and obstructive sleep apnoea: a randomized clinical trial","volume":"24","author":"Johnston","year":"2002","journal-title":"European Journal of Orthodontics"},{"key":"key\n\t\t\t\t20170614075205_bib26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/sleep\/29.2.240","article-title":"Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances: an update for 2005","volume":"29","author":"Kushida","year":"2006","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20170614075205_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/ejo\/20.3.293","article-title":"Effect of two types of mandibular advancement splints on snoring and obstructive sleep apnoea","volume":"20","author":"Lamont","year":"1998","journal-title":"European Journal of Orthodontics"},{"key":"key\n\t\t\t\t20170614075205_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/ejo\/cjh067","article-title":"A comparison of the Twin Block and Herbst mandibular advancement splints in the treatment of patients with obstructive sleep apnoea: a prospective study","volume":"27","author":"Lawton","year":"2005","journal-title":"European Journal of Orthodontics"},{"key":"key\n\t\t\t\t20170614075205_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004435.pub3","article-title":"Oral appliances for obstructive sleep apnoea","author":"Lim","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"key\n\t\t\t\t20170614075205_bib30","first-page":"15","article-title":"Factors related to the efficacy of an adjustable oral appliance for the treatment of obstructive sleep apnea","volume":"3","author":"Liu","year":"2000","journal-title":"Chinese Journal of Dental Research"},{"key":"key\n\t\t\t\t20170614075205_bib31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1378\/chest.113.3.707","article-title":"The effect of a mandibular advancement device on apneas and sleep in patients with obstructive sleep apnea","volume":"113","author":"Marklund","year":"1998","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170614075205_bib32","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1164\/ajrccm.163.6.2004213","article-title":"A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea","volume":"163","author":"Mehta","year":"2001","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib33","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1378\/chest.105.2.429","article-title":"Predictive factors of long-term compliance with nasal continuous positive airway pressure treatment in sleep apnea syndrome","volume":"105","author":"Meurice","year":"1994","journal-title":"Chest"},{"key":"key\n\t\t\t\t20170614075205_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2165\/00151829-200504060-00005","article-title":"Oral appliance therapy for obstructive sleep apnea","volume":"4","author":"Ng","year":"2005","journal-title":"Treatments in Respiratory Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib35","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200005113421901","article-title":"Prospective study of the association between sleep-disordered breathing and hypertension","volume":"342","author":"Peppard","year":"2000","journal-title":"New England Journal of Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2869.2008.00645.x","article-title":"Mandibular advancement appliance for obstructive sleep apnea: results of a randomized placebo controlled trial using parallel group design","volume":"17","author":"Petri","year":"2008","journal-title":"Journal of Sleep Research"},{"key":"key\n\t\t\t\t20170614075205_bib37","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1164\/rccm.200204-342OC","article-title":"Effect of vertical dimension on efficacy of oral appliance therapy in obstructive sleep apnea","volume":"166","author":"Pitsis","year":"2002","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib38","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1513\/pats.200709-155MG","article-title":"The epidemiology of adult obstructive sleep apnea","volume":"5","author":"Punjabi","year":"2008","journal-title":"Proceedings of the American Thoracic Society"},{"key":"key\n\t\t\t\t20170614075205_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ejo\/24.2.191","article-title":"A comparative study of two mandibular advancement appliances for the treatment of obstructive sleep apnoea","volume":"24","author":"Rose","year":"2002","journal-title":"European Journal of Orthodontics"},{"key":"key\n\t\t\t\t20170614075205_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1034\/j.1600-0722.2002.11178.x","article-title":"Treatment of obstructive sleep apnoea with the Karwetzky oral appliance","volume":"110","author":"Rose","year":"2002","journal-title":"European Journal of Oral Science"},{"key":"key\n\t\t\t\t20170614075205_bib41","first-page":"487","article-title":"Rules of evidence and clinical recommendations for the management of patients","volume":"9","author":"Sackett","year":"1993","journal-title":"Canadian Journal of Cardiology"},{"key":"key\n\t\t\t\t20170614075205_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm.163.1.2001008","article-title":"Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study","volume":"163","author":"Shahar","year":"2001","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002875","article-title":"Lifestyle modification for obstructive sleep apnoea","author":"Shneerson","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"key\n\t\t\t\t20170614075205_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003002.pub2","article-title":"Drug therapy for obstructive sleep apnoea in adults","author":"Smith","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"key\n\t\t\t\t20170614075205_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001004.pub2","article-title":"Surgery for obstructive sleep apnoea","author":"Sundaram","year":"2005","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"key\n\t\t\t\t20170614075205_bib46","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/00016350310007130","article-title":"Two different degrees of mandibular advancement with a dental appliance in treatment of patients with mild to moderate obstructive sleep apnea","volume":"61","author":"Tegelberg","year":"2003","journal-title":"Acta Odontologica Scandinavica"},{"key":"key\n\t\t\t\t20170614075205_bib47","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1164\/rccm.200701-114OC","article-title":"Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea","volume":"178","author":"Vanderveken","year":"2008","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11325-003-0119-3","article-title":"A prospective randomized study comparing two different degrees of mandibular advancement with a dental appliance in treatment of severe obstructive sleep apnea","volume":"7","author":"Walker-Engstr\u00f6m","year":"2003","journal-title":"Sleep and Breathing"},{"key":"key\n\t\t\t\t20170614075205_bib49","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.smrv.2006.08.001","article-title":"Continuous positive airway pressure treatment for sleep apnea in older adults","volume":"11","author":"Weaver","year":"2007","journal-title":"Sleep Medicine Reviews"},{"key":"key\n\t\t\t\t20170614075205_bib50","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1056\/NEJM199304293281704","article-title":"The occurrence of sleep disordered breathing among middle aged adults","volume":"328","author":"Young","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"key\n\t\t\t\t20170614075205_bib51","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/sleep\/20.9.705","article-title":"Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women","volume":"20","author":"Young","year":"1997","journal-title":"Sleep"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/33\/3\/318\/17713305\/cjq079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T03:22:05Z","timestamp":1503458525000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article-lookup\/doi\/10.1093\/ejo\/cjq079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,13]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,1,13]]},"published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjq079","relation":{},"ISSN":["1460-2210","0141-5387"],"issn-type":[{"value":"1460-2210","type":"electronic"},{"value":"0141-5387","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,13]]}}}