{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:35:57Z","timestamp":1788820557697,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T00:00:00Z","timestamp":1506124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,25]]},"DOI":"10.1093\/ejo\/cjx060","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T11:08:47Z","timestamp":1503659327000},"page":"273-280","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of obstructive sleep apnoea\u2013hypopnea syndrome by mandible advanced device reduced neuron apoptosis in frontal cortex of rabbits"],"prefix":"10.1093","volume":"40","author":[{"given":"Hai-yan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Orthodontics, College of Stomatology, Hebei Medical University; The Key Laboratory of Stomatology, Hebei Province, Shijiazhuang, Hebei, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Stomatology, Hebei Medical University; The Key Laboratory of Stomatology, Hebei Province, Shijiazhuang, Hebei, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Detroit Mercy, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Stomatology, Hebei Medical University; The Key Laboratory of Stomatology, Hebei Province, Shijiazhuang, Hebei, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Stomatology, Hebei Medical University; The Key Laboratory of Stomatology, Hebei Province, Shijiazhuang, Hebei, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, FengTai Hospital, Beijing, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-sheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Hebei Medical University; The Key Laboratory of Stomatology, Hebei Province, Shijiazhuang, Hebei, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, College of Stomatology, Hebei Medical University; The Key Laboratory of Stomatology, Hebei Province, Shijiazhuang, Hebei, P.R. of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,23]]},"reference":[{"key":"key\n\t\t\t\t20180525045821_CIT0001","first-page":"E298","article-title":"Clinical manifestations of sleep apnea","volume":"7","author":"Stansbury","year":"2015","journal-title":"Journal of Thoracic Disease"},{"key":"key\n\t\t\t\t20180525045821_CIT0002","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/09540260500104508","article-title":"Effect of sleep apnea on cognition and mood","volume":"17","author":"El-Ad","year":"2005","journal-title":"International Review of Psychiatry"},{"key":"key\n\t\t\t\t20180525045821_CIT0003","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1183\/09031936.04.00127603","article-title":"Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study","volume":"24","author":"Alchanatis","year":"2004","journal-title":"The European Respiratory Journal"},{"key":"key\n\t\t\t\t20180525045821_CIT0004","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.expneurol.2008.01.030","article-title":"Chronic hypobaric hypoxia induced apoptosis in CA1 region of hippocampus: a possible role of NMDAR mediated p75NTR upregulation","volume":"212","author":"Hota","year":"2008","journal-title":"Experimental Neurology"},{"key":"key\n\t\t\t\t20180525045821_CIT0005","doi-asserted-by":"crossref","first-page":"e81808","DOI":"10.1371\/journal.pone.0081808","article-title":"Intermittent hypoxia can aggravate motor neuronal loss and cognitive dysfunction in ALS mice","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180525045821_CIT0006","first-page":"117","article-title":"Influence of different degrees of chronic intermittent hypoxia on c-fos protein and apoptosis in rats","volume":"47","author":"Li","year":"2012","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"key\n\t\t\t\t20180525045821_CIT0007","first-page":"701","article-title":"Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein","volume":"34","author":"Tan","year":"2013","journal-title":"Saudi Medical Journal"},{"key":"key\n\t\t\t\t20180525045821_CIT0008","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1248\/yakushi.125.549","article-title":"Behavioral and neurochemical alterations following thiamine deficiency in rodents: relationship to functions of cholinergic neurons","volume":"125","author":"Nakagawasai","year":"2005","journal-title":"Yakugaku Zasshi"},{"key":"key\n\t\t\t\t20180525045821_CIT0009","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbr.2006.09.015","article-title":"Central nicotinic cholinergic systems: a role in the cognitive dysfunction in attention-deficit\/hyperactivity disorder","volume":"175","author":"Potter","year":"2006","journal-title":"Behavioural Brain Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0010","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.parkreldis.2015.09.017","article-title":"Interaction between basal ganglia and limbic circuits in learning and memory processes","volume":"22","author":"Calabresi","year":"2016","journal-title":"Parkinsonism and Related Disorders"},{"key":"key\n\t\t\t\t20180525045821_CIT0011","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1472-6882-12-188","article-title":"Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF\/PDGF mechanisms in the brain","volume":"12","author":"Zhao","year":"2012","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"key\n\t\t\t\t20180525045821_CIT0012","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180525045821_CIT0013","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.brainres.2008.10.029","article-title":"Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer\u2019s disease","volume":"1249","author":"Watanabe","year":"2009","journal-title":"Brain Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0014","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.freeradbiomed.2012.01.023","article-title":"Early memory deficits precede plaque deposition in APPswe\/PS1dE9 mice: involvement of oxidative stress and cholinergic dysfunction","volume":"52","author":"Zhang","year":"2012","journal-title":"Free Radical Biology and Medicine"},{"key":"key\n\t\t\t\t20180525045821_CIT0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archneur.1974.00490320001001","article-title":"Human memory and the cholinergic system. A relationship to aging","volume":"30","author":"Drachman","year":"1974","journal-title":"Archives of Neurology"},{"key":"key\n\t\t\t\t20180525045821_CIT0016","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbr.2015.03.029","article-title":"The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer\u2019s disease mouse model","volume":"287","author":"Puri","year":"2015","journal-title":"Behavioural Brain Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0017","first-page":"1","article-title":"Improvement in physical activity in persons with obstructive sleep apnea treated with continuous positive airway pressure","volume":"20","author":"Jean","year":"2016","journal-title":"Journal of Physical Activity and Health"},{"key":"key\n\t\t\t\t20180525045821_CIT0018","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.sleep.2016.06.023","article-title":"Continuous positive airway pressure treatment impact on memory processes in obstructive sleep apnea patients: a randomized sham-controlled trial","volume":"24","author":"Joyeux-Faure","year":"2016","journal-title":"Sleep Medicine"},{"key":"key\n\t\t\t\t20180525045821_CIT0019","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/thorax.55.3.224","article-title":"Randomised prospective parallel trial of therapeutic versus subtherapeutic nasal continuous positive airway pressure on simulated steering performance in patients with obstructive sleep apnoea","volume":"55","author":"Hack","year":"2000","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20180525045821_CIT0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.sleep.2008.03.011","article-title":"Efficacy of two mandibular advancement appliances in the management of snoring and mild-moderate sleep apnea: a cross-over randomized study","volume":"10","author":"Gauthier","year":"2009","journal-title":"Sleep Medicine"},{"key":"key\n\t\t\t\t20180525045821_CIT0021","doi-asserted-by":"crossref","first-page":"S223","DOI":"10.4103\/0975-7406.155915","article-title":"Mandibular advancement device for obstructive sleep apnea: an overview","volume":"7","author":"Jayesh","year":"2015","journal-title":"Journal of Pharmacy and Bioallied Sciences"},{"key":"key\n\t\t\t\t20180525045821_CIT0022","first-page":"267","article-title":"Surgical treatment of snoring & obstructive sleep apnoea","volume":"131","author":"Ephros","year":"2010","journal-title":"The Indian Journal of Medical Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0023","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.5665\/sleep.2226","article-title":"Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the Apnea Positive Pressure Long-term Efficacy Study (APPLES)","volume":"35","author":"Kushida","year":"2012","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20180525045821_CIT0024","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/ejo\/cju041","article-title":"An animal model of obstructive sleep apnoea-hypopnea syndrome corrected by mandibular advancement device","volume":"37","author":"Lu","year":"2015","journal-title":"European Journal of Orthodontics"},{"key":"key\n\t\t\t\t20180525045821_CIT0025","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/ejo\/cju042","article-title":"Effects of a mandibular advancement device on genioglossus in obstructive sleep apnoea hypopnea syndrome","volume":"37","author":"Liu","year":"2015","journal-title":"European Journal of Orthodontics"},{"key":"key\n\t\t\t\t20180525045821_CIT0026","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1152\/jappl.1987.63.4.1344","article-title":"The English bulldog: a natural model of sleep-disordered breathing","volume":"63","author":"Hendricks","year":"1987","journal-title":"Journal of Applied Physiology"},{"key":"key\n\t\t\t\t20180525045821_CIT0027","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1569-9048(03)00082-X","article-title":"Collapsible upper airway segment to study the obstructive sleep apnea\/hypopnea syndrome in rats","volume":"136","author":"Farr\u00e9","year":"2003","journal-title":"Respiratory Physiology and Neurobiology"},{"key":"key\n\t\t\t\t20180525045821_CIT0028","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specifcation","author":"Iber","year":"2007"},{"key":"key\n\t\t\t\t20180525045821_CIT0029","first-page":"126","article-title":"Overview of sleep & sleep disorders","volume":"131","author":"Chokroverty","year":"2010","journal-title":"The Indian Journal of Medical Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0030","doi-asserted-by":"crossref","first-page":"490","DOI":"10.7555\/JBR.30.20160110","article-title":"Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model","volume":"30","author":"Wei","year":"2016","journal-title":"Journal of Biomedical Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0031","article-title":"Detection and analysis of apoptosis- and autophagy-related miRNAs of vascular endothelial cells in a mouse chronic intermittent hypoxia model","author":"Liu","year":"2016","journal-title":"Life Science"},{"key":"key\n\t\t\t\t20180525045821_CIT0032","doi-asserted-by":"crossref","first-page":"8215082","DOI":"10.1155\/2016\/8215082","article-title":"Roles and mechanisms of obstructive sleep apnea-hypopnea syndrome and chronic intermittent hypoxia in atherosclerosis: evidence and prospective","volume":"2016","author":"Ma","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"key\n\t\t\t\t20180525045821_CIT0033","doi-asserted-by":"crossref","first-page":"1015390","DOI":"10.1155\/2016\/1015390","article-title":"Soluble receptor for advanced Glycation end product ameliorates chronic intermittent hypoxia induced renal injury, inflammation, and apoptosis via P38\/JNK signaling pathways","volume":"2016","author":"Wu","year":"2016","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"key\n\t\t\t\t20180525045821_CIT0034","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.expneurol.2008.12.003","article-title":"Recurrent apnea induces neuronal apoptosis in the guinea pig forebrain","volume":"216","author":"Zhang","year":"2009","journal-title":"Experimental Neurology"},{"key":"key\n\t\t\t\t20180525045821_CIT0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.nbd.2010.05.032","article-title":"Apnea produces neuronal degeneration in the pons and medulla of guinea pigs","volume":"40","author":"Zhang","year":"2010","journal-title":"Neurobiology of Disease"},{"key":"key\n\t\t\t\t20180525045821_CIT0036","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/j.semperi.2004.08.002","article-title":"Apoptosis and neurogenesis after transient hypoxia in the developing rat brain","volume":"28","author":"Daval","year":"2004","journal-title":"Seminars in Perinatology"},{"key":"key\n\t\t\t\t20180525045821_CIT0037","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1523\/JNEUROSCI.4468-06.2007","article-title":"Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation","volume":"27","author":"Abramov","year":"2007","journal-title":"The Journal of Neuroscience"},{"key":"key\n\t\t\t\t20180525045821_CIT0038","doi-asserted-by":"crossref","first-page":"9653","DOI":"10.1007\/s11357-014-9653-0","article-title":"Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system","volume":"36","author":"Haider","year":"2014","journal-title":"Age"},{"key":"key\n\t\t\t\t20180525045821_CIT0039","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuint.2006.06.002","article-title":"Hypobaric hypoxia induces oxidative stress in rat brain","volume":"49","author":"Maiti","year":"2006","journal-title":"Neurochemistry International"},{"key":"key\n\t\t\t\t20180525045821_CIT0040","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1378\/chest.15-0171","article-title":"Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA: a randomized pilot study","volume":"148","author":"Dalmases","year":"2015","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180525045821_CIT0041","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.5665\/sleep.2950","article-title":"Executive dysfunction in OSA before and after treatment: a meta-analysis","volume":"36","author":"Olaithe","year":"2013","journal-title":"Sleep"},{"key":"key\n\t\t\t\t20180525045821_CIT0042","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.smrv.2012.09.002","article-title":"Neuropsychological functioning after CPAP treatment in obstructive sleep apnea: a meta-analysis","volume":"17","author":"Kylstra","year":"2013","journal-title":"Sleep Medicine Reviews"},{"key":"key\n\t\t\t\t20180525045821_CIT0043","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1017\/S1355617710000901","article-title":"Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure","volume":"16","author":"Lau","year":"2010","journal-title":"Journal of the International Neuropsychological Society"},{"key":"key\n\t\t\t\t20180525045821_CIT0044","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.patbio.2014.05.015","article-title":"Cognitive impairment in obstructive sleep apnea","volume":"62","author":"Gagnon","year":"2014","journal-title":"Pathologie-Biologie"},{"key":"key\n\t\t\t\t20180525045821_CIT0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/thorax.57.4.283","article-title":"Are oral appliances a substitute for nasal positive airway pressure","volume":"57","author":"Millman","year":"2002","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20180525045821_CIT0046","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-444-63274-6.00014-X","article-title":"Affective brain areas and sleep-disordered breathing","volume":"209","author":"Harper","year":"2014","journal-title":"Progress in Brain Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0047","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.mehy.2013.06.024","article-title":"The cholinergic system may play a role in the pathophysiology of residual excessive sleepiness in patients with obstructive sleep apnea","volume":"81","author":"Otuyama","year":"2013","journal-title":"Medical Hypotheses"},{"key":"key\n\t\t\t\t20180525045821_CIT0048","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1021\/cn500319m","article-title":"Interpreting chemical neurotransmission in vivo: techniques, time scales, and theories","volume":"6","author":"Sarter","year":"2015","journal-title":"ACS Chemical Neuroscience"},{"key":"key\n\t\t\t\t20180525045821_CIT0049","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11010-013-1615-9","article-title":"Evaluation of acetylcholinesterase and adenosine deaminase activities in brain and erythrocytes and proinflammatory cytokine levels in rats submitted to neonatal hypoxia-ischemia model","volume":"378","author":"Pimentel","year":"2013","journal-title":"Molecular and Cellular Biochemistry"},{"key":"key\n\t\t\t\t20180525045821_CIT0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainres.2008.06.081","article-title":"Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia","volume":"1230","author":"Udayabanu","year":"2008","journal-title":"Brain Research"},{"key":"key\n\t\t\t\t20180525045821_CIT0051","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.33549\/physiolres.932374","article-title":"Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis","volume":"61","author":"Rauchov\u00e1","year":"2012","journal-title":"Physiological Research"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/40\/3\/273\/24841848\/cjx060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T07:39:40Z","timestamp":1692949180000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/40\/3\/273\/4191336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,23]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9,23]]},"published-print":{"date-parts":[[2018,5,25]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjx060","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,6]]},"published":{"date-parts":[[2017,9,23]]}}}