{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:39:34Z","timestamp":1740141574500,"version":"3.37.3"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T00:00:00Z","timestamp":1539388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The innovative study presented by Huang and co-workers in this issue of the European Journal of Orthodontics is one of the first giving insight into the mostly disregarded world of non-coding ribonucleic acids in orthodontics. In other fields of science non-coding ribonucleic acids have been shown to play a major role in the regulation of cell metabolism as well as the aetiology of diseases such as cancer, Alzheimer\u2019s disease, and periodontitis. Their pilot study on the possible function of differentially expressed long non-coding ribonucleic acids during mechanical compression of periodontal ligament stem cells, as well as methodological approach of whole-transcriptome sequencing with bioinformatory analyses, provides ample possibilities for future basic orthodontic research, which will hopefully greatly expand our knowledge of tooth movement regulation. This field could provide new therapeutic opportunities and diagnostic and treatment aids for orthodontists as well as our patients. This commentary will discuss the implications and importance of the findings of Huang and co-workers in the context of current research in orthodontics and molecular biology.<\/jats:p>","DOI":"10.1093\/ejo\/cjy069","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T07:14:08Z","timestamp":1537341248000},"page":"343-345","source":"Crossref","is-referenced-by-count":2,"title":["The fascinating world of non-coding RNA and how it may help to unravel the mysteries of tooth movement regulation"],"prefix":"10.1093","volume":"41","author":[{"given":"Peter","family":"Proff","sequence":"first","affiliation":[{"name":"Department of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-8724","authenticated-orcid":false,"given":"Christian","family":"Kirschneck","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, University Medical Centre of Regensburg, Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,10,13]]},"reference":[{"key":"2019080802044911900_CIT0001","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ejo\/cjl001","article-title":"The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt","volume":"28","author":"Meikle","year":"2006","journal-title":"European Journal of Orthodontics"},{"key":"2019080802044911900_CIT0002","doi-asserted-by":"crossref","DOI":"10.1002\/9781118916148","volume-title":"Biological mechanisms of tooth movement","author":"Krishnan","year":"2015"},{"key":"2019080802044911900_CIT0003","article-title":"The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force","author":"Huang","year":"2018","journal-title":"European Journal of Orthodontics"},{"key":"2019080802044911900_CIT0004","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.archoralbio.2016.08.014","article-title":"The role of microRNA in periodontal tissue: a review of the literature","volume":"72","author":"Irwandi","year":"2016","journal-title":"Archives of Oral Biology"},{"key":"2019080802044911900_CIT0005","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1177\/0022034516657043","article-title":"microRNA-21 contributes to orthodontic tooth movement","volume":"95","author":"Chen","year":"2016","journal-title":"Journal of Dental Research"},{"key":"2019080802044911900_CIT0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.gene.2015.03.055","article-title":"Cyclic stretch and compression forces alter microRNA-29 expression of human periodontal ligament cells","volume":"566","author":"Chen","year":"2015","journal-title":"Gene"},{"key":"2019080802044911900_CIT0007","doi-asserted-by":"crossref","first-page":"e0194238","DOI":"10.1371\/journal.pone.0194238","article-title":"Secretory microRNA-29 expression in gingival crevicular fluid during orthodontic tooth movement","volume":"13","author":"Atsawasuwan","year":"2018","journal-title":"PLoS One"},{"key":"2019080802044911900_CIT0008","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/41\/4\/343\/29108383\/cjy069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T02:05:10Z","timestamp":1565229910000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/41\/4\/343\/5129089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,13]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,10,13]]},"published-print":{"date-parts":[[2019,8,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjy069","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"type":"print","value":"0141-5387"},{"type":"electronic","value":"1460-2210"}],"subject":[],"published-other":{"date-parts":[[2019,8]]},"published":{"date-parts":[[2018,10,13]]}}}