{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:00:45Z","timestamp":1780362045713,"version":"3.54.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T00:00:00Z","timestamp":1566086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, the potential impact of different medications on the rate of orthodontic tooth movement and the associated root resorption has been systematically reviewed in animal studies and various effects have been shown. However, animal data cannot be extrapolated to human clinical situations directly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To systematically investigate the most up to date available evidence from controlled human studies regarding the effect of medication administration on the rate of orthodontic tooth movement and associated root resorption development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search methods<\/jats:title><jats:p>We searched eight databases (covering also grey literature) without restrictions and we performed hand searching up until October 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Controlled studies in humans assessing the effect of various medications on the rate of orthodontic tooth movement and root resorption development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Study selection was followed by data extraction and risk of bias assessment using the ROBINS-I tool for non-randomized and the Cochrane Risk of Bias Tool for randomized studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies, at various risk of bias, were finally identified. With regard to the rate of orthodontic tooth movement, local injections of prostaglandin E1 were found to exert an increasing effect, whereas systemic intake of nabumetone decreased it. Following tenoxicam administration, drinking water with fluoride or local injections of calcitriol (vitamin D metabolite), no significant effects were demonstrated. Concerning root resorption development, nabumetone administration was shown to reduce it, whereas fluoride, overall, was not observed to exert any effect. Only in individuals subjected to heavy orthodontic forces, did fluoride show a protective effect for the period of force application, but not in the longer term during retention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The aforementioned substances may show varying effects on the rate of orthodontic tooth movement and root resorption development in human subjects. Despite the observed limitations, the orthodontist should be able to identify patients taking pharmaceuticals and consider any implications related to orthodontic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration<\/jats:title><jats:p>PROSPERO (CRD42017078208).<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejo\/cjz063","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T19:17:03Z","timestamp":1563995823000},"page":"407-414","source":"Crossref","is-referenced-by-count":24,"title":["Does medication administration affect the rate of orthodontic tooth movement and root resorption development in humans? A systematic review"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-5110","authenticated-orcid":false,"given":"Eleftherios G","family":"Kaklamanos","sequence":"first","affiliation":[{"name":"Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis A","family":"Makrygiannakis","sequence":"additional","affiliation":[{"name":"Private practice limited to Orthodontics, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios E","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"Department of Dentistry, European University Cyprus, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,18]]},"reference":[{"key":"2020091108240510200_CIT0001","volume-title":"Contemporary Orthodontics","author":"Proffit","year":"2013","edition":"5th edn"},{"key":"2020091108240510200_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000351894","article-title":"Periodontal ligament and alveolar bone in health and adaptation: tooth movement","volume":"18","author":"Jiang","year":"2016","journal-title":"Frontiers of Oral Biology,"},{"key":"2020091108240510200_CIT0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000351895","article-title":"Cellular and molecular aspects of bone remodeling","volume":"18","author":"Xiao","year":"2016","journal-title":"Frontiers of Oral Biology,"},{"key":"2020091108240510200_CIT0004","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0022034516677539","article-title":"Cellular and molecular pathways leading to external root resorption","volume":"96","author":"Iglesias-Linares","year":"2017","journal-title":"Journal of Dental Research,"},{"key":"2020091108240510200_CIT0005","volume-title":"Health, United States, 2016: With Chartbook on Long-term Trends in Health","author":"National Center for Health Statistics","year":"2017"},{"key":"2020091108240510200_CIT0006","article-title":"Pharmaceutical consumption","volume-title":"Health at a Glance: Europe 2014","author":"Organisation of Economic Cooperation and Development.","year":"2014"},{"key":"2020091108240510200_CIT0007","volume-title":"World Population Ageing 2017\u2014Highlights (ST\/ESA\/SER.A\/397)","author":"United Nations, Department of Economic and Social Affairs, Population Division","year":"2017"},{"key":"2020091108240510200_CIT0008","volume-title":"Economics of Orthodontics and Patient Census","author":"American Association of Orthodontists","year":"2016"},{"key":"2020091108240510200_CIT0009","first-page":"72","article-title":"Orthodontics and its interactions with other dental disciplines","volume":"10","author":"Mavreas","year":"2009","journal-title":"Progress in Orthodontics,"},{"key":"2020091108240510200_CIT0010","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1001\/jama.2018.5690","article-title":"Trends in prescription medication use among children and adolescents-United States, 1999-2014","volume":"319","author":"Hales","year":"2018","journal-title":"JAMA,"},{"key":"2020091108240510200_CIT0011","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1001\/jamainternmed.2015.8581","article-title":"Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs 2011","volume":"176","author":"Qato","year":"2016","journal-title":"JAMA Internal Medicine,"},{"key":"2020091108240510200_CIT0012","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ejo\/cjy001","article-title":"Does common prescription medication affect the rate of orthodontic tooth movement? A systematic review","volume":"40","author":"Makrygiannakis","year":"2018","journal-title":"European Journal of Orthodontics,"},{"key":"2020091108240510200_CIT0013","doi-asserted-by":"crossref","DOI":"10.1093\/ejo\/cjy001","article-title":"Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies","author":"Makrygiannakis","year":"2018","journal-title":"European Journal of Orthodontics"},{"key":"2020091108240510200_CIT0014","article-title":"Does long-term use of pain relievers have an impact on the rate of orthodontic tooth movement? A systematic review of animal studies","author":"Makrygiannakis","year":"2018","journal-title":"European Journal of Orthodontics"},{"key":"2020091108240510200_CIT0015","first-page":"17","article-title":"Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism and elimination.","volume-title":"Goodman and Gilman\u2019s: The Pharmacological Basis of Therapeutics","author":"Buxton","year":"2011"},{"key":"2020091108240510200_CIT0016","first-page":"g7647","article-title":"Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ (Clinical research ed.),"},{"key":"2020091108240510200_CIT0017","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins","year":"2011"},{"key":"2020091108240510200_CIT0018","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"62","author":"Liberati","year":"2009","journal-title":"Journal of Clinical Epidemiology,"},{"key":"2020091108240510200_CIT0019","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: a tool for assessing risk of bias in a non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"2020091108240510200_CIT0020","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"2020091108240510200_CIT0021","doi-asserted-by":"crossref","DOI":"10.1002\/9780470743386","volume-title":"Introduction to Meta-Analysis","author":"Borenstein","year":"2009"},{"key":"2020091108240510200_CIT0022","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Controlled Clinical Trials,"},{"key":"2020091108240510200_CIT0023","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jclinepi.2010.09.011","article-title":"GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology","volume":"64","author":"Guyatt","year":"2011","journal-title":"Journal of Clinical Epidemiology,"},{"key":"2020091108240510200_CIT0024","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ajodo.2003.04.006","article-title":"Comparison of some effects of acetylsalicylic acid and rofecoxib during orthodontic tooth movement","volume":"125","author":"Sari","year":"2004","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0025","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4103\/0970-9290.152170","article-title":"Effect of Prostaglandin E1 versus corticotomy on orthodontic tooth movement: an in vivo study","volume":"6","author":"Rajasekaran","year":"2014","journal-title":"Indian Journal of Dental Research"},{"key":"2020091108240510200_CIT0026","first-page":"694","article-title":"Evaluation of the influence of local administration of vitamin D on the rate of orthodontic tooth movement","volume":"120","author":"Iosub Ciur","year":"2016","journal-title":"Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,"},{"key":"2020091108240510200_CIT0027","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0002-9416(84)90091-5","article-title":"Clinical application of prostaglandin E1 (PGE1) upon orthodontic tooth movement","volume":"85","author":"Yamasaki","year":"1984","journal-title":"American Journal of Orthodontics,"},{"key":"2020091108240510200_CIT0028","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/154405910608500813","article-title":"Clodronate inhibits PGE(2) production in compressed periodontal ligament cells","volume":"85","author":"Liu","year":"2006","journal-title":"Journal of Dental Research,"},{"key":"2020091108240510200_CIT0029","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/ejo\/cjt053","article-title":"Effects of various analgesics on the level of prostaglandin E2 during orthodontic tooth movement","volume":"36","author":"Tun\u00e7er","year":"2014","journal-title":"European Journal of Orthodontics,"},{"key":"2020091108240510200_CIT0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/0974909820050204","article-title":"The clinical application of Prostaglandin E1 on orthodontic tooth movement\u2014a clinical trial","volume":"38","author":"Patil","year":"2005","journal-title":"Journal of Indian Orthodontic Society"},{"key":"2020091108240510200_CIT0031","first-page":"162","article-title":"Acceleration of orthodontically induced tooth movement through the local application of prostaglandin (PGE1)","volume":"99","author":"Spielmann","year":"1989","journal-title":"Schweizer Monatsschrift f\u00fcr Zahnmedizin"},{"key":"2020091108240510200_CIT0032","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/01.DON.0000134212.20525.74","article-title":"Pulp-dentine complex changes and root resorption during intrusive orthodontic tooth movement in patients prescribed nabumetone","volume":"31","author":"Villa","year":"2005","journal-title":"Journal of Endodontics,"},{"key":"2020091108240510200_CIT0033","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1601-6343.2008.01432.x","article-title":"Tenoxicam controls pain without altering orthodontic movement of maxillary canines","volume":"12","author":"Arantes","year":"2009","journal-title":"Orthodontics and Craniofacial Research,"},{"key":"2020091108240510200_CIT0034","first-page":"139","article-title":"Clinical efficacy of locally injected calcitriol in orthodontic tooth movement","volume":"3","author":"Al-Hasani","year":"2011","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"2020091108240510200_CIT0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2478\/aoj-2011-0012","article-title":"The effect of fluoride on orthodontic tooth movement in humans. A two- and three-dimensional evaluation","volume":"27","author":"Karadeniz","year":"2011","journal-title":"Australian Orthodontic Journal,"},{"key":"2020091108240510200_CIT0036","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1016\/j.ajodo.2011.05.017","article-title":"Physical properties of root cementum: part 20. Effect of fluoride on orthodontically induced root resorption with light and heavy orthodontic forces for 4 weeks: a microcomputed tomography study","volume":"140","author":"Karadeniz","year":"2011","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0037","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2319\/072512-606.1","article-title":"Effect of fluoride on root resorption following heavy and light orthodontic force application for 4 weeks and 12 weeks of retention","volume":"83","author":"Karadeniz","year":"2013","journal-title":"Angle Orthodontist,"},{"key":"2020091108240510200_CIT0038","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s11914-016-0340-1","article-title":"Bone density and dental external apical root resorption","volume":"14","author":"Iglesias-Linares","year":"2016","journal-title":"Current Osteoporosis Reports,"},{"key":"2020091108240510200_CIT0039","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ejo\/cjn020","article-title":"Mechanobiology of tooth movement","volume":"30","author":"Henneman","year":"2008","journal-title":"European Journal of Orthodontics,"},{"key":"2020091108240510200_CIT0040","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/9781118916148.ch13","article-title":"The effect of drugs and diet on orthodontic tooth movement.","volume-title":"Biological Mechanisms of Tooth Movement","author":"Krishnan","year":"2015","edition":"2nd edn"},{"key":"2020091108240510200_CIT0041","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/ejo\/cjq173","article-title":"Non-steroidal and steroidal anti-inflammatory use in the context of orthodontic movement","volume":"34","author":"Knop","year":"2012","journal-title":"European Journal of Orthodontics,"},{"key":"2020091108240510200_CIT0042","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.lfs.2015.01.009","article-title":"Repercussions of NSAIDS drugs on bone tissue: the osteoblast","volume":"123","author":"Garc\u00eda-Mart\u00ednez","year":"2015","journal-title":"Life Sciences,"},{"key":"2020091108240510200_CIT0043","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annual Review of Biochemistry,"},{"key":"2020091108240510200_CIT0044","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1067\/mod.2000.105872","article-title":"Non-steroidal anti-inflammatory drugs in orthodontic tooth movement\u2014metalloproteinase activity and collagen synthesis by endothelial cells","volume":"118","author":"Kyrkanides","year":"2000","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1345\/aph.10185","article-title":"NSAID impairment of orthodontic tooth movement","volume":"35","author":"Walker","year":"2001","journal-title":"Annals of Pharmacotherapy,"},{"key":"2020091108240510200_CIT0046","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/07435800009040151","article-title":"The effect of prostaglandin E1 on human bone metabolism: evaluation by biochemical markers for bone turnover","volume":"26","author":"Takahashi","year":"2000","journal-title":"Endocrine Research,"},{"key":"2020091108240510200_CIT0047","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2174\/1574887111308010008","article-title":"Effect of non-steroidal anti-inflammatory drugs on bone turnover: an evidence-based review","volume":"8","author":"Konstantinidis","year":"2013","journal-title":"Reviews on Recent Clinical Trials,"},{"key":"2020091108240510200_CIT0048","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/187152809788681065","article-title":"Controversial effects of non-steroidal anti-inflammatory drugs on bone: a review","volume":"8","author":"Salari","year":"2009","journal-title":"Inflammation and Allergy Drug Targets,"},{"key":"2020091108240510200_CIT0049","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1210\/endo.139.2.5751","article-title":"Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research","volume":"139","author":"Aerssens","year":"1998","journal-title":"Endocrinology,"},{"key":"2020091108240510200_CIT0050","doi-asserted-by":"crossref","first-page":"606404","DOI":"10.1100\/2012\/606404","article-title":"Do nonsteroidal anti-inflammatory drugs affect bone healing? A critical analysis","volume":"2012","author":"Pountos","year":"2012","journal-title":"ScientificWorldJournal,"},{"key":"2020091108240510200_CIT0051","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1177\/154405910208100610","article-title":"Estrous-cycle-dependent variation in orthodontic tooth movement","volume":"81","author":"Haruyama","year":"2002","journal-title":"Journal of Dental Research,"},{"key":"2020091108240510200_CIT0052","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ajodo.2003.06.002","article-title":"Comparison of the effects of 1,25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement","volume":"125","author":"Kale","year":"2004","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0053","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.175.4023.768","article-title":"1, 25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture","volume":"175","author":"Raisz","year":"1972","journal-title":"Science"},{"key":"2020091108240510200_CIT0054","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0889-5406(88)90052-2","article-title":"The local use of vitamin D to increase the rate of orthodontic tooth movement","volume":"94","author":"Collins","year":"1988","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ejo\/13.3.223","article-title":"The effects of pregnancy and fluoride on orthodontic tooth movements in rats","volume":"13","author":"Hellsing","year":"1991","journal-title":"European Journal of Orthodontics,"},{"key":"2020091108240510200_CIT0056","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ajodo.2009.05.029","article-title":"Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption","volume":"139","author":"Gonzales","year":"2011","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0057","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jtemb.2016.09.004","article-title":"Fluoride affects bone repair differently in mice models with distinct bone densities","volume":"39","author":"Herrera","year":"2017","journal-title":"Journal of Trace Elements in Medicine and Biology"},{"key":"2020091108240510200_CIT0058","first-page":"293","article-title":"[Effect of fluoride on the skeletal system]","volume":"39","author":"Franke","year":"1984","journal-title":"Zeitschrift fur die Gesamte Innere Medizin und Ihre Grenzgebiete,"},{"key":"2020091108240510200_CIT0059","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1002\/jbmr.5650051381","article-title":"The effects of sodium fluoride on the resorptive activity of isolated osteoclasts","volume":"5","author":"Okuda","year":"1990","journal-title":"Journal of Bone and Mineral Research"},{"key":"2020091108240510200_CIT0060","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1002\/jbmr.5650051391","article-title":"The effect of fluoride on the resorption of dentine by osteoclasts in vitro","volume":"5","author":"Taylor","year":"1990","journal-title":"Journal of Bone and Mineral Research"},{"key":"2020091108240510200_CIT0061","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ajodo.2005.02.030","article-title":"Physical properties of root cementum: part 9. Effect of systemic fluoride intake on root resorption in rats","volume":"131","author":"Foo","year":"2007","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0062","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1016\/j.ajodo.2009.12.028","article-title":"Physical properties of root cementum: part 15. Analysis of elemental composition by using proton-induced x-ray and gamma-ray emissions in orthodontically induced root resorption craters of rat molar cementum after exposure to systemic fluoride","volume":"139","author":"Lim","year":"2011","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"},{"key":"2020091108240510200_CIT0063","doi-asserted-by":"crossref","first-page":"320.e1","DOI":"10.1016\/j.ajodo.2008.05.014","article-title":"Physical properties of root cementum: part 13. Repair of root resorption 4 and 8 weeks after the application of continuous light and heavy forces for 4 weeks: a microcomputed-tomography study","volume":"136","author":"Cheng","year":"2009","journal-title":"American Journal of Orthodontics and Dentofacial Orthopedics"}],"container-title":["European Journal of Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/42\/4\/407\/33734877\/cjz063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ejo\/article-pdf\/42\/4\/407\/33734877\/cjz063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T14:21:15Z","timestamp":1695046875000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejo\/article\/42\/4\/407\/5550992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,18]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,8,18]]},"published-print":{"date-parts":[[2020,9,11]]}},"URL":"https:\/\/doi.org\/10.1093\/ejo\/cjz063","relation":{},"ISSN":["0141-5387","1460-2210"],"issn-type":[{"value":"0141-5387","type":"print"},{"value":"1460-2210","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8,1]]},"published":{"date-parts":[[2019,8,18]]}}}