{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:11:18Z","timestamp":1779300678800,"version":"3.51.4"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[1998,9,1]]},"DOI":"10.1093\/emboj\/17.17.5151","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:44:48Z","timestamp":1027709088000},"page":"5151-5160","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Chromatin immunoselection defines a TAL\u20101 target gene"],"prefix":"10.1038","volume":"17","author":[{"given":"Sylvia","family":"Cohen\u2010Kaminsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le\u00efla","family":"Maouche\u2010Chr\u00e9tien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Vitelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Antoinette","family":"Vinit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayugi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Peschle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul\u2010Henri","family":"Rom\u00e9o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1998,9,1]]},"reference":[{"key":"BFEMBJ7591210_CR1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/384270a0","volume":"384","author":"AD Agulnick","year":"1996","unstructured":"Agulnick AD, Taira M, Breen JJ, Tanaka T, Dawid IB and Westphal H (1996) Functional and physical interaction of Ldb1, a novel LIM domain binding factor, with the LIM homeodomain protein Lhx1\/Xlim 1. Nature, 384, 270\u2013272.","journal-title":"Nature"},{"key":"BFEMBJ7591210_CR2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0021-9258(17)42195-8","volume":"269","author":"WC Aird","year":"1994","unstructured":"Aird WC, Parvin JD, Sharp PA and Rosenberg RD (1994) The interaction of GATA\u2010binding proteins and basal transcription factors with GATA box\u2010containing core promoters. A model of tissue\u2010specific gene expression. J Biol Chem, 269, 883\u2013889.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591210_CR3","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Sch\u00e4ffer AA, Zhang J, Zhang Z, Miller W and Lipman DJ (1997) Gapped BLAST and PSI\u2010BLAST: a new generation of protein database search programs. Nucleic Acids Res, 25, 3389\u20133402.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7591210_CR4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1182\/blood.V79.5.1327.1327","volume":"79","author":"PD Aplan","year":"1992","unstructured":"Aplan PD, Lombardi DP, Reaman GH, Sather HN, Hammond GD and Kirsch IR (1992a) Involvement of the putative hematopoietic transcription factor SCL in T\u2010cell acute lymphoblastic leukemia. Blood, 79, 1327\u20131333.","journal-title":"Blood"},{"key":"BFEMBJ7591210_CR5","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1002\/j.1460-2075.1992.tb05500.x","volume":"11","author":"PD Aplan","year":"1992","unstructured":"Aplan PD, Nakahara K, Orkin SH and Kirsch IR (1992b) The SCL gene product: a positive regulator of erythroid differentiation. EMBO J, 11, 4073\u20134081.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR6","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1093\/emboj\/16.9.2408","volume":"16","author":"PD Aplan","year":"1997","unstructured":"Aplan PD, Jones CA, Chervinsky DS, Zhao X, Ellsworth MK, Wu C, McGuire EA and Gross KW (1997) An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T\u2010cell malignancies in transgenic mice. EMBO J, 16, 2408\u20132419.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR7","first-page":"341","volume":"4","author":"R Baer","year":"1993","unstructured":"Baer R (1993) TAL1, TAL2 and LYL1: a family of basic helix\u2013loop\u2013helix proteins implicated in T cell acute leukaemia. Semin Cancer Biol, 4, 341\u2013347.","journal-title":"Semin Cancer Biol"},{"key":"BFEMBJ7591210_CR8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1182\/blood.V86.2.666.bloodjournal862666","volume":"86","author":"RO Bash","year":"1995","unstructured":"Bash RO, Hall S, Timmons CF, Crist WM, Amylon M, Smith RG and Baer R (1995) Does activation of the TAL1 gene occur in a majority of patients with T\u2010cell acute lymphoblastic leukemia? A pediatric oncology group study. Blood, 86, 666\u2013676.","journal-title":"Blood"},{"key":"BFEMBJ7591210_CR9","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.86.6.2031","volume":"86","author":"CG Begley","year":"1989","unstructured":"Begley CG et al. (1989) Chromosomal translocation in a human leukemic stem\u2010cell line disrupts the T\u2010cell antigen receptor \u03b4\u2010chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci USA, 86, 2031\u20132035.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/gcc.2870010303","volume":"1","author":"O Bernard","year":"1990","unstructured":"Bernard O, Guglielmi P, Jonveaux P, Cherif D, Gisselbrecht S, Mauchauffe M, Berger R, Larsen CJ and Mathieu\u2010Mahul D (1990) Two distinct mechanisms for the SCL gene activation in the t (1;14) translocation of T\u2010cell leukemias. Genes Chromosom Cancer, 1, 194\u2013208.","journal-title":"Genes Chromosom Cancer"},{"key":"BFEMBJ7591210_CR11","first-page":"7621","volume":"14","author":"J Bigler","year":"1994","unstructured":"Bigler J and Eisenman RN (1994) Isolation of a thyroid hormone\u2010responsive gene by immunoprecipitation of thyroid hormone receptor\u2010DNA complexes. Mol Cell Biol, 14, 7621\u20137632.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591210_CR12","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1002\/j.1460-2075.1995.tb00258.x","volume":"14","author":"J Bigler","year":"1995","unstructured":"Bigler J and Eisenman RN (1995) Novel location and function of a thyroid hormone response element. EMBO J, 14, 5710\u20135723.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR13","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1073\/pnas.88.10.4367","volume":"88","author":"T Boehm","year":"1991","unstructured":"Boehm T, Foroni L, Kaneko Y, Perutz MP and Rabbitts TH (1991) The rhombotin family of cysteine\u2010rich LIM\u2010domain oncogenes: Distinct members are involved in T\u2010cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci USA, 88, 4367\u20134371.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR14","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1242\/dev.122.12.3839","volume":"122","author":"K Briegel","year":"1996","unstructured":"Briegel K, Bartunek P, Stengl G, Lim K\u2010C, Beug H, Engel JD and Zenke M (1996) Regulation and function of transcription factor GATA\u20101 during red blood cell differentiation. Development, 122, 3839\u20133850.","journal-title":"Development"},{"key":"BFEMBJ7591210_CR15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/j.1460-2075.1990.tb08126.x","volume":"9","author":"Q Chen","year":"1990","unstructured":"Chen Q et al. (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix\u2013loop\u2013helix protein. EMBO J, 9, 415\u2013424.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR16","doi-asserted-by":"crossref","first-page":"14450","DOI":"10.1073\/pnas.94.26.14450","volume":"94","author":"M Cohen\u2010Salmon","year":"1997","unstructured":"Cohen\u2010Salmon M, El\u2010Amraoui A, Leibovici M and Petit C (1997) Otogelin: A glycoprotein specific to the acellular membranes of the inner ear. Proc Natl Acad Sci USA, 94, 14450\u201314455.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1182\/blood.V86.1.164.bloodjournal861164","volume":"86","author":"G Condorelli","year":"1995","unstructured":"Condorelli G, Vitelli L, Valtieri M, Marta I, Montesoro E, Lulli V, Baer R and Peschle C (1995) Coordinate expression and developmental role of Id2 protein and TAL1\/E2A heterodimer in erythroid progenitor differentiation. Blood, 86, 164\u2013175.","journal-title":"Blood"},{"key":"BFEMBJ7591210_CR18","first-page":"5113","volume":"56","author":"GL Condorelli","year":"1996","unstructured":"Condorelli GL, Facchiano F, Valtieri M, Proietti E, Vitelli L, Lulli V, Huebner K, Peschle C and Croce CM (1996) T\u2010cell\u2010directed TAL\u20101 expression induces T\u2010cell malignancies in transgenic mice. Cancer Res, 56, 5113\u20135119.","journal-title":"Cancer Res"},{"key":"BFEMBJ7591210_CR19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1101\/gad.10.4.447","volume":"10","author":"L Desbarats","year":"1996","unstructured":"Desbarats L, Gaubatz S and Eilers M (1996) Discrimination between different E\u2010box\u2010binding proteins at an endogenous target gene of c\u2010myc. Genes Dev, 10, 447\u2013460.","journal-title":"Genes Dev"},{"key":"BFEMBJ7591210_CR20","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1093\/emboj\/16.18.5654","volume":"16","author":"S Deveaux","year":"1997","unstructured":"Deveaux S, Cohen\u2010Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I, Orkin SH, Rom\u00e9o P\u2010H and Mignotte V (1997) p45 NF\u2010E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J, 16, 5654\u20135661.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR21","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1073\/pnas.86.13.5039","volume":"86","author":"LR Finger","year":"1989","unstructured":"Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC and Croce CM (1989) Involvement of the TCL5 gene on human chromosome 1 in T\u2010cell leukemia and melanoma. Proc Natl Acad Sci USA, 86, 5039\u20135043.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR22","first-page":"3838","volume":"10","author":"J Frampton","year":"1990","unstructured":"Frampton J, Walker M, Plumb M and Harrison PR (1990) Synergy between the NF\u2010E1 erythroid\u2010specific transcription factor and the CACCC factor in the erythroid\u2010specific promoter of the human porphobilinogen deaminase gene. Mol Cell Biol, 10, 3838\u20133842.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591210_CR23","first-page":"1167","volume":"116","author":"AP Gould","year":"1992","unstructured":"Gould AP and White RAH (1992) Connectin, a target of homeotic gene control in Drosophila Development, 116, 1167\u20131174.","journal-title":"Drosophila Development"},{"key":"BFEMBJ7591210_CR24","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/348308a0","volume":"348","author":"AP Gould","year":"1990","unstructured":"Gould AP, Brookman JJ, Strutt DI and White RAH (1990) Targets of homeotic gene control in Drosophila. Nature, 348, 308\u2013312.","journal-title":"Nature"},{"key":"BFEMBJ7591210_CR25","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1002\/j.1460-2075.1992.tb05416.x","volume":"11","author":"Y Graba","year":"1992","unstructured":"Graba Y, Aragnol D, Laurenti P, Garzino V, Charmot D, Berenger H and Pradel J (1992) Homeotic control in Drosophila: the scabrous gene is an in vivo target of Ultrabithorax proteins. EMBO J, 11, 3375\u20133384.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR26","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1002\/j.1460-2075.1996.tb00808.x","volume":"15","author":"C Grandori","year":"1996","unstructured":"Grandori C, Mac J, Si\u00ebbelt F, Ayer DE and Eisenmann RN (1996) Myc\u2013Max heterodimers activate a DEAD box gene and interact with multiple E box\u2010related sites in vivo. EMBO J, 15, 4344\u20134357.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/383575a0","volume":"383","author":"T Green","year":"1996","unstructured":"Green T (1996) Master regulator unmasked. Nature, 383, 575\u2013576.","journal-title":"Nature"},{"key":"BFEMBJ7591210_CR28","first-page":"653","volume":"7","author":"AR Green","year":"1992","unstructured":"Green AR, Lints T, Visvader J, Harvey R and Begley CG (1992) SCL is coexpressed with GATA\u20101 in hemopoietic cells but is also expressed in developing brain. Oncogene, 7, 653\u2013660.","journal-title":"Oncogene"},{"key":"BFEMBJ7591210_CR29","first-page":"3037","volume":"11","author":"H\u2010L Hsu","year":"1991","unstructured":"Hsu H\u2010L, Cheng J\u2010T, Chen Q and Baer R (1991) Enhancer\u2010binding activity of the tal\u20101 oncoprotein in association with the E47\/E12 helix\u2013loop\u2013helix proteins. Mol Cell Biol, 11, 3037\u20133042.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591210_CR30","first-page":"1256","volume":"14","author":"H\u2010L Hsu","year":"1994","unstructured":"Hsu H\u2010L, Huang LH, Tsou Tsan J, Funk W, Wright WE, Hu J\u2010S, Kingston RE and Baer R (1994a) Preferred sequences for DNA recognition by the TAL1 helix\u2013loop\u2013helix proteins. Mol Cell Biol, 14, 1256\u20131265.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591210_CR31","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1073\/pnas.91.8.3181","volume":"91","author":"HL Hsu","year":"1994","unstructured":"Hsu HL, Wadman I and Baer R (1994b) Formation of in vivo complexes between the TAL\u20101 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci USA, 91, 3181\u20133185.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR32","doi-asserted-by":"crossref","first-page":"5947","DOI":"10.1073\/pnas.91.13.5947","volume":"91","author":"H\u2010L Hsu","year":"1994","unstructured":"Hsu H\u2010L, Wadman I, Tsou Tsan J and Baer R (1994c) Positive and negative transcriptional control by the TAL1 helix\u2013loop\u2013helix protein. Proc Natl Acad Sci USA, 91, 5947\u20135951.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR33","doi-asserted-by":"crossref","first-page":"11693","DOI":"10.1073\/pnas.93.21.11693","volume":"93","author":"LW Jurata","year":"1996","unstructured":"Jurata LW, Kenny DA and Gill GN (1996) Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development. Proc Natl Acad Sci USA, 93, 11693\u201311698.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR34","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V83.5.1200.1200","volume":"83","author":"AR Kallianpur","year":"1994","unstructured":"Kallianpur AR, Jordan JE and Brandt SJ (1994) The SCL\/TAL\u20101 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood, 83, 1200\u20131208.","journal-title":"Blood"},{"key":"BFEMBJ7591210_CR35","first-page":"473","volume":"13","author":"G Keller","year":"1993","unstructured":"Keller G, Kennedy M, Papayannopoulou T and Wiles MV (1993) Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol, 13, 473\u2013486.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591210_CR36","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1002\/j.1460-2075.1996.tb00900.x","volume":"15","author":"MA Kelliher","year":"1996","unstructured":"Kelliher MA, Seldin DC and Leder P (1996) Tal\u20101 induces T cell acute lymphoblastic leukemia accelerated by casein kinase II\u03b1. EMBO J, 15, 5160\u20135166.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR37","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/j.1460-2075.1996.tb00439.x","volume":"15","author":"RC Larson","year":"1996","unstructured":"Larson RC, Lavenir I, Larson TA, Baer R, Warren AJ, Wadman I, Nottage K and Rabbitts TH (1996) Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J, 15, 1021\u20131027.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR38","first-page":"668","volume":"13","author":"V Lemarchandel","year":"1993","unstructured":"Lemarchandel V, Ghysdael J, Mignotte V, Rahuel C and Rom\u00e9o P\u2010H (1993) GATA and Ets cis\u2010acting sequences mediate megakaryocyte\u2010specific expression. Mol Cell Biol, 13, 668\u2013676.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591210_CR39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/dbio.1996.8454","volume":"182","author":"C Lemercier","year":"1997","unstructured":"Lemercier C, To RQ, Swanson BJ, Lyons GE and Konieczny SF (1997) Mist1: a novel basic helix\u2013loop\u2013helix transcription factor exhibits a developmentally regulated expression pattern. Dev Biol, 182, 101\u2013113.","journal-title":"Dev Biol"},{"key":"BFEMBJ7591210_CR40","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/emboj\/17.5.1412","volume":"17","author":"C Lemercier","year":"1998","unstructured":"Lemercier C, To RQ, Carrasco RA and Konieczny SF (1998) The basic helix\u2013loop\u2013helix transcription factor Mist1 functions as a transcriptional repressor of MyoD. EMBO J, 17, 1412\u20131422.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR41","first-page":"718","volume":"16","author":"FM Lemoine","year":"1988","unstructured":"Lemoine FM, Humphries RK, Abraham SDM and Krystal G (1988) Partial characterization of a novel stromal cell\u2010derived pre\u2010B\u2010cell growth factor active on normal and immortalized pre\u2010B cells. Exp Hematol, 16, 718\u2013726.","journal-title":"Exp Hematol"},{"key":"BFEMBJ7591210_CR42","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0092-8674(89)90434-0","volume":"58","author":"C Murre","year":"1989","unstructured":"Murre C et al. (1989) Interactions between heterologous helix\u2013loop\u2013helix proteins generate complexes that bind specifically to a common DNA sequence. Cell, 58, 537\u2013544.","journal-title":"Cell"},{"key":"BFEMBJ7591210_CR43","first-page":"131","volume":"11","author":"AM Murrell","year":"1995","unstructured":"Murrell AM, Bockamp E\u2010O, G\u00f6ttgens B, Chan YS, Cross MA, Heyworth CM and Green AR (1995) Discordant regulation of SCL\/TAL\u20101 mRNA and protein during erythroid differentiation. Oncogene, 11, 131\u2013139.","journal-title":"Oncogene"},{"key":"BFEMBJ7591210_CR44","doi-asserted-by":"crossref","first-page":"31463","DOI":"10.1074\/jbc.271.49.31463","volume":"271","author":"AL Nielsen","year":"1996","unstructured":"Nielsen AL, N\u00f8rby PL, Pedersen FS and J\u00f8rgensen P (1996) E\u2010box sequence and context\u2010dependent TAL1\/SCL modulaton of basic helix\u2013loop\u2013helix protein\u2010mediated transcriptional activation. J Biol Chem, 271, 31463\u201331469.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591210_CR45","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1073\/pnas.92.21.9585","volume":"92","author":"H Osada","year":"1995","unstructured":"Osada H, Grutz G, Axelson H, Forster A and Rabbitts TH (1995) Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc\u2010finger protein GATA1. Proc Natl Acad Sci USA, 92, 9585\u20139589.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR46","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/349257a0","volume":"349","author":"L Pevny","year":"1991","unstructured":"Pevny L, Simon MC, Robertson E, Klein WH, Tsai S\u2010F, D'Agati V, Orkin SH and Costantini F (1991) Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA\u20101. Nature, 349, 257\u2013260.","journal-title":"Nature"},{"key":"BFEMBJ7591210_CR47","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1074\/jbc.271.14.7978","volume":"271","author":"DE Phelps","year":"1996","unstructured":"Phelps DE and Dressler GR (1996) Identification of novel Pax\u20102 binding sites by chromatin precipitation. J Biol Chem, 271, 7978\u20137985.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591210_CR48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80076-8","volume":"86","author":"C Porcher","year":"1996","unstructured":"Porcher C, Swat W, Rockwell K, Fujiwara Y, Alt FW and Orkin SH (1996) The T cell leukemia oncoprotein SCL\/tal\u20101 is essential for development of all hematopoietic lineages. Cell, 86, 47\u201357.","journal-title":"Cell"},{"key":"BFEMBJ7591210_CR49","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1182\/blood.V85.3.675.bloodjournal853675","volume":"85","author":"K Pulford","year":"1995","unstructured":"Pulford K, Lecointe N, Leroy\u2010Viard K, Jones M, Mathieu\u2010Mahul D and Mason DY (1995) Expression of TAL\u20101 proteins in human tissues. Blood, 85, 675\u2013684.","journal-title":"Blood"},{"key":"BFEMBJ7591210_CR50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/372143a0","volume":"372","author":"TH Rabbitts","year":"1994","unstructured":"Rabbitts TH (1994) Chromosomal translocations in human cancer. Nature, 372, 143\u2013149.","journal-title":"Nature"},{"key":"BFEMBJ7591210_CR51","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1002\/j.1460-2075.1992.tb05502.x","volume":"11","author":"C Rahuel","year":"1992","unstructured":"Rahuel C, Vinit M\u2010A, Lemarchandel V, Cartron J\u2010P and Rom\u00e9o P\u2010H (1992) Erythroid\u2010specific activity of the glycophorin B promoter requires GATA\u20101 mediated displacement of a repressor. EMBO J, 11, 4095\u20134102.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR52","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/j.1460-2075.1995.tb07058.x","volume":"14","author":"N Raich","year":"1995","unstructured":"Raich N, Clegg CH, Grofti J, Rom\u00e9o P\u2010H and Stamatoyannopoulos G (1995) GATA1 and YY1 are developmental repressors of the human epsilon\u2010globin gene. EMBO J, 14, 801\u2013809.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR53","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1073\/pnas.92.15.7075","volume":"92","author":"L Robb","year":"1995","unstructured":"Robb L, Lyons I, Li R, Hartley L, K\u00f6ntgen F, Harvey RP, Metcalf D and Begley CG (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci USA, 92, 7075\u20137079.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR54","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1002\/j.1460-2075.1996.tb00787.x","volume":"15","author":"L Robb","year":"1996","unstructured":"Robb L, Elwood NJ, Elefanty AG, Kontgen F, Li R, Barnet LD and Begley CG (1996) The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J, 15, 4123\u20134129.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR55","first-page":"1887","volume":"6","author":"B Royer\u2010Pokora","year":"1991","unstructured":"Royer\u2010Pokora B, Loos U and Ludwig W\u2010D (1991) TTG\u20102, a new gene encoding a cysteine\u2010rich protein with the LIM motif, is overexpressed in acute T\u2010cell leukaemia with the t (11;14) (p13;q11). Oncogene, 6, 1887\u20131893.","journal-title":"Oncogene"},{"key":"BFEMBJ7591210_CR56","volume-title":"Molecular Cloning. A Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning. A Laboratory Manual, Second Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.","edition":"Second"},{"key":"BFEMBJ7591210_CR57","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","volume":"17","author":"E Schreiber","year":"1989","unstructured":"Schreiber E, Matthias P, M\u00fcller MM and Schaffner W (1989) Rapid detection of octamer binding proteins with \u2018mini extracts\u2019, prepared from a small number of cells. Nucleic Acids Res, 17, 6419.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7591210_CR58","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1182\/blood.V87.10.4025.bloodjournal87104025","volume":"87","author":"RA Shivdasani","year":"1996","unstructured":"Shivdasani RA and Orkin SH (1996) The transcriptional control of hematopoiesis. Blood, 87, 4025\u20134039.","journal-title":"Blood"},{"key":"BFEMBJ7591210_CR59","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/373432a0","volume":"373","author":"RA Shivdasani","year":"1995","unstructured":"Shivdasani RA, Mayer EL and Orkin SH (1995) Absence of blood formation in mice lacking the T\u2010cell leukaemia oncoprotein tal\u20101\/SCL. Nature, 373, 432\u2013434.","journal-title":"Nature"},{"key":"BFEMBJ7591210_CR60","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0592-92","volume":"1","author":"MC Simon","year":"1992","unstructured":"Simon MC, Pevny L, Wiles MV, Keller G, Costantini F and Orkin SH (1992) Rescue of erythroid development in gene targeted GATA\u20101 mouse embryonic stem cells. Nature Genet, 1, 92\u201397.","journal-title":"Nature Genet"},{"key":"BFEMBJ7591210_CR61","doi-asserted-by":"crossref","first-page":"8617","DOI":"10.1073\/pnas.91.18.8617","volume":"91","author":"VE Valge\u2010Archer","year":"1994","unstructured":"Valge\u2010Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R and Rabbitts TH (1994) The LIM protein RBTN2 and the basic helix\u2013loop\u2013helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci USA, 91, 8617\u20138621.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR62","first-page":"187","volume":"6","author":"J Visvader","year":"1991","unstructured":"Visvader J, Begley CG and Adams JM (1991) Differential expression of the LYL, SCL and E2A helix\u2013loop\u2013helix genes within the hemopoietic system. Oncogene, 6, 187\u2013194.","journal-title":"Oncogene"},{"key":"BFEMBJ7591210_CR63","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1073\/pnas.94.25.13707","volume":"94","author":"JE Visvader","year":"1997","unstructured":"Visvader JE, Mao X, Fujiwara Y, Hahm K and Orkin SH (1997) The LIM\u2010domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci USA, 94, 13707\u201313712.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591210_CR64","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1101\/gad.12.4.473","volume":"12","author":"JE Visvader","year":"1998","unstructured":"Visvader JE, Fujiwara Y and Orkin SH (1998) Unsuspected role for the T\u2010cell leukemia protein SCL\/tal\u20101 in vascular development. Genes Dev, 12, 473\u2013479.","journal-title":"Genes Dev"},{"key":"BFEMBJ7591210_CR65","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/j.1460-2075.1990.tb08176.x","volume":"9","author":"J Voorberg","year":"1990","unstructured":"Voorberg J, Fontijn R, van Mourik J and Pannekoek H (1990) Domains involved in multimer assembly of von Willebrand factor (vWF): multimerization is independent of dimerization. EMBO J, 9, 797\u2013803.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR66","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1002\/j.1460-2075.1994.tb06809.x","volume":"13","author":"I Wadman","year":"1994","unstructured":"Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH and Baer R (1994) Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J, 13, 4831\u20134839.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR67","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1093\/emboj\/16.11.3145","volume":"16","author":"IA Wadman","year":"1997","unstructured":"Wadman IA, Osada H, Gr\u00fctz GG, Agulnick AD, Westphal H, Forster A and Rabbitts TH (1997) The LIM\u2010only protein Lmo2 is a bridging molecule assembling an erythroid, DNA\u2010binding complex which includes the TAL1, E47, GATA\u20101 and Ldb1\/NLI proteins. EMBO J, 16, 3145\u20133157.","journal-title":"EMBO J"},{"key":"BFEMBJ7591210_CR68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0092-8674(94)90571-1","volume":"78","author":"AJ Warren","year":"1994","unstructured":"Warren AJ, Colledge WH, Carlton MBL, Evans MJ, Smith AJH and Rabbitts TH (1994) The oncogenic cysteine\u2010rich LIM domain protein Rbtn2 is essential for erythroid development. Cell, 78, 45\u201358.","journal-title":"Cell"},{"key":"BFEMBJ7591210_CR69","first-page":"99","volume":"23","author":"MJ Weiss","year":"1995","unstructured":"Weiss MJ and Orkin SH (1995) GATA transcription factors: key regulators of hematopoiesis. Exp Hematol, 23, 99\u2013107.","journal-title":"Exp Hematol"},{"key":"BFEMBJ7591210_CR70","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2443.1997.1080305.x","volume":"2","author":"M Yamamoto","year":"1997","unstructured":"Yamamoto M, Takahashi S, Onodera K, Muraosa Y and Engel JD (1997) Upstream and downstream of erythroid transcription factor GATA\u20101. Genes Cells, 2, 107\u2013115.","journal-title":"Genes Cells"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2F17.17.5151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/17.17.5151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/17.17.5151\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/17.17.5151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/17.17.5151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:59:19Z","timestamp":1779299959000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/17.17.5151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":70,"journal-issue":{"issue":"17","published-print":{"date-parts":[[1998,9,1]]}},"alternative-id":["BFEMBJ7591210"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/17.17.5151","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9,1]]},"assertion":[{"value":"12 December 1997","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 1998","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 1998","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 1998","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}