{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:55:07Z","timestamp":1789012507894,"version":"build-2803163510"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1999,1,4]],"date-time":"1999-01-04T00:00:00Z","timestamp":915408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1999,1,4]],"date-time":"1999-01-04T00:00:00Z","timestamp":915408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[1999,1,4]]},"DOI":"10.1093\/emboj\/18.1.145","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:47:12Z","timestamp":1027709232000},"page":"145-155","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS\u2013MAPK pathway and RAP1"],"prefix":"10.1038","volume":"18","author":[{"given":"Satoshi","family":"Ishimaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidesaburo","family":"Hanafusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Gaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1999,1,4]]},"reference":[{"key":"BFEMBJ7591452_CR1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/dev.122.4.1137","volume":"122","author":"JD Allard","year":"1996","unstructured":"Allard JD, Chang HC, Herbst R, McNeill H and Simon MA (1996) The SH2\u2010containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf. Development, 122, 1137\u20131146.","journal-title":"Development"},{"key":"BFEMBJ7591452_CR2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/0092-8674(94)90271-2","volume":"78","author":"A Aronheim","year":"1994","unstructured":"Aronheim A, Engelberg D, Li N, al\u2010Alawi N, Schlessinger J and Karin M (1994) Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell, 78, 949\u2013961.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0092-8674(91)90262-W","volume":"64","author":"K Basler","year":"1991","unstructured":"Basler K, Christen B and Hafen E (1991) Ligand\u2010independent activation of the Sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell, 64, 1069\u20131081.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR4","doi-asserted-by":"crossref","first-page":"10588","DOI":"10.1016\/S0021-9258(19)50057-6","volume":"267","author":"R Birge","year":"1992","unstructured":"Birge R, Fajardo J, Mayer BJ and Hanafusa H (1992) Tyrosine phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyse Crk\u2010phosphotyrosine\u2010dependent interactions in vitro. J Biol Chem, 267, 10588\u201310595.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591452_CR5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2443.1996.00258.x","volume":"1","author":"RB Birge","year":"1996","unstructured":"Birge RB, Knudsen BS, Besser D and Hanafusa H (1996) SH2 and SH3\u2010containing adaptor proteins: redundant or independent mediators of intracellular signal transduction. Genes Cells, 1, 595\u2013613.","journal-title":"Genes Cells"},{"key":"BFEMBJ7591452_CR6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand AH and Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development, 118, 401\u2013415.","journal-title":"Development"},{"key":"BFEMBJ7591452_CR7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(94)90362-X","volume":"76","author":"D Brunner","year":"1994","unstructured":"Brunner D, Oellers N, Szabad J, Biggs WH, Zipursky SL and Hafen E (1994) A gain\u2010of\u2010function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell, 76, 875\u2013888.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.7716514","volume":"268","author":"EA Clark","year":"1995","unstructured":"Clark EA and Brugge JS (1995) Integrins and signal transduction pathways: the road taken. Science, 268, 233\u2013239.","journal-title":"Science"},{"key":"BFEMBJ7591452_CR9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/genetics\/137.2.531","volume":"137","author":"R Clifford","year":"1994","unstructured":"Clifford R and Sch\u00fcpbach T (1994) Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein. Genetics, 137, 531\u2013550.","journal-title":"Genetics"},{"key":"BFEMBJ7591452_CR10","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1101\/gad.6.12a.2327","volume":"6","author":"B Dickson","year":"1992","unstructured":"Dickson B, Sprenger F and Hafen E (1992a) Prepattern in the developing Drosophila eye revealed by an activated torso\u2013sevenless chimeric receptor. Genes Dev, 6, 2327\u20132339.","journal-title":"Genes Dev"},{"key":"BFEMBJ7591452_CR11","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/360600a0","volume":"360","author":"B Dickson","year":"1992","unstructured":"Dickson B, Sprenger F, Morrison D and Hafen E (1992b) Raf functions downstream of Ras1 in the Sevenless signal transduction pathway. Nature, 360, 600\u2013603.","journal-title":"Nature"},{"key":"BFEMBJ7591452_CR12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1242\/dev.119.3.855","volume":"119","author":"MC Ellis","year":"1993","unstructured":"Ellis MC, O'Neill EM and Rubin GM (1993) Expression of Drosophila glass protein and evidence for negative regulation of its activity in non\u2010neuronal cells by another DNA\u2010binding protein. Development, 119, 855\u2013865.","journal-title":"Development"},{"key":"BFEMBJ7591452_CR13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/355559a0","volume":"355","author":"ME Fortini","year":"1992","unstructured":"Fortini ME, Simon MA and Rubin GM (1992) Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation. Nature, 355, 559\u2013561.","journal-title":"Nature"},{"key":"BFEMBJ7591452_CR14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0092-8674(00)81385-9","volume":"87","author":"M Freeman","year":"1996","unstructured":"Freeman M (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell, 87, 651\u2013660.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR15","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1242\/dev.124.18.3535","volume":"124","author":"L Gabay","year":"1997","unstructured":"Gabay L, Seger R and Shilo BZ (1997) MAP kinase in situ activation atlas during Drosophila embryogenesis. Development, 124, 3535\u20133541.","journal-title":"Development"},{"key":"BFEMBJ7591452_CR16","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0092-8674(92)90073-L","volume":"68","author":"U Gaul","year":"1992","unstructured":"Gaul U, Mardon G and Rubin GM (1992) A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase. Cell, 68, 1007\u20131019.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR17","doi-asserted-by":"crossref","first-page":"6746","DOI":"10.1128\/MCB.15.12.6746","volume":"15","author":"T Gotoh","year":"1995","unstructured":"Gotoh T et al. (1995) Identification of Rap1 as a target for the Crk SH3 domain\u2010binding guanine nucleotide\u2010releasing factor C3G. Mol Cell Biol, 15, 6746\u20136753.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591452_CR18","doi-asserted-by":"crossref","first-page":"18602","DOI":"10.1074\/jbc.272.30.18602","volume":"272","author":"T Gotoh","year":"1997","unstructured":"Gotoh T, Niino Y, Tokuda M, Hatase O, Nakamura S, Matsuda M and Hattori S (1997) Activation of R\u2010Ras by Ras\u2010guanine nucleotide\u2010releasing factor. J Biol Chem, 272, 18602\u201318607.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591452_CR19","first-page":"1443","volume":"7","author":"H Greulich","year":"1996","unstructured":"Greulich H and Hanafusa H (1996) A role for Ras in v\u2010Crk transformation. Cell Growth Differ, 7, 1443\u20131451.","journal-title":"Cell Growth Differ"},{"key":"BFEMBJ7591452_CR20","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0092-8674(91)90066-8","volume":"67","author":"IK Hariharan","year":"1991","unstructured":"Hariharan IK, Carthew RW and Rubin GM (1991) The Drosophila roughened mutation: activation of a rap homolog disrupts eye development and interferes with cell determination. Cell, 67, 717\u2013722.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR21","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/0092-8674(95)90150-7","volume":"83","author":"BA Hay","year":"1995","unstructured":"Hay BA, Wassarman DA and Rubin GM (1995) Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell, 83, 1253\u20131262.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR22","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0092-8674(00)81273-8","volume":"85","author":"R Herbst","year":"1996","unstructured":"Herbst R, Carroll PM, Allard JD, Schilling J, Raabe T and Simon MA (1996) Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during Sevenless signaling. Cell, 85, 899\u2013909.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0955-0674(98)80143-9","volume":"10","author":"YT Ip","year":"1998","unstructured":"Ip YT and Davis RJ (1998) Signal transduction by the c\u2010Jun N\u2010terminal kinase (JNK)\u2014from inflammation to development. Curr Opin Cell Biol, 10, 205\u2013219.","journal-title":"Curr Opin Cell Biol"},{"key":"BFEMBJ7591452_CR24","first-page":"2641","volume":"11","author":"S Jones","year":"1991","unstructured":"Jones S, Vignais ML and Broach JR (1991) The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras. Mol Cell Biol, 11, 2641\u20132646.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591452_CR25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0092-8674(84)90534-8","volume":"38","author":"RE Karess","year":"1984","unstructured":"Karess RE and Rubin GM (1984) Analysis of P transposable element functions in Drosophila. Cell, 38, 135\u2013146.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.125.1.1","volume":"125","author":"FD Karim","year":"1998","unstructured":"Karim FD and Rubin GM (1998) Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues. Development, 125, 1\u20139.","journal-title":"Development"},{"key":"BFEMBJ7591452_CR27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/genetics\/143.1.315","volume":"143","author":"FD Karim","year":"1996","unstructured":"Karim FD, Chang HC, Therrien M, Wassarman DA, Laverty T and Rubin GM (1996) A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics, 143, 315\u2013329.","journal-title":"Genetics"},{"key":"BFEMBJ7591452_CR28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1101\/gad.4.5.712","volume":"4","author":"BE Kimmel","year":"1990","unstructured":"Kimmel BE, Heberlein U and Rubin GM (1990) The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes Dev, 4, 712\u2013727.","journal-title":"Genes Dev"},{"key":"BFEMBJ7591452_CR29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0092-8674(89)90985-9","volume":"56","author":"H Kitayama","year":"1989","unstructured":"Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y and Noda M (1989) A ras\u2010related gene with transformation suppressor activity. Cell, 56, 77\u201384.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR30","doi-asserted-by":"crossref","first-page":"32781","DOI":"10.1016\/S0021-9258(20)30059-4","volume":"269","author":"BS Knudsen","year":"1994","unstructured":"Knudsen BS, Feller SM and Hanafusa H (1994) Four proline\u2010rich sequences of the guanine\u2010nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. J Biol Chem, 269, 32781\u201332787.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591452_CR31","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1002\/j.1460-2075.1995.tb07213.x","volume":"14","author":"BS Knudsen","year":"1995","unstructured":"Knudsen BS, Zheng J, Feller SM, Mayer JP, Burrell SK, Cowburn D and Hanafusa H (1995) Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins. EMBO J, 14, 2191\u20132198.","journal-title":"EMBO J"},{"key":"BFEMBJ7591452_CR32","first-page":"1345","volume":"13","author":"CC Lai","year":"1993","unstructured":"Lai CC, Boguski M, Broek D and Powers S (1993) Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins. Mol Cell Biol, 13, 1345\u20131352.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591452_CR33","doi-asserted-by":"crossref","first-page":"4810","DOI":"10.1128\/MCB.15.9.4810","volume":"15","author":"K\u2010MV Lai","year":"1995","unstructured":"Lai K\u2010MV, Olivier JP, Gish GD, Henkemeyer M, McGlade J and Pawson T (1995) A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase. Mol Cell Biol, 15, 4810\u20134818.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591452_CR34","doi-asserted-by":"crossref","first-page":"12515","DOI":"10.1073\/pnas.94.23.12515","volume":"94","author":"Q Li","year":"1997","unstructured":"Li Q, Hariharan IK, Chen F, Huang Y and Fischer JA (1997) Genetic interactions with Rap1 and Ras1 reveal a second function for the Fat facets deubiquitinating enzyme in Drosophila eye development. Proc Natl Acad Sci USA, 94, 12515\u201312520.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591452_CR35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1101\/gad.7.4.621","volume":"7","author":"X Lu","year":"1993","unstructured":"Lu X, Chou TB, Williams NG, Roberts T and Perrimon N (1993) Control of cell fate determination by p21ras\/Ras1, an essential component of torso signaling in Drosophila. Genes Dev, 7, 621\u2013632.","journal-title":"Genes Dev"},{"key":"BFEMBJ7591452_CR36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0168-9525(97)01355-3","volume":"14","author":"MA Marra","year":"1998","unstructured":"Marra MA, Hillier L and Waterston RH (1998) Expressed sequence tags\u2014ESTablishing bridges between genomes. Trends Genet, 14, 4\u20137.","journal-title":"Trends Genet"},{"key":"BFEMBJ7591452_CR37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0959-437X(94)90095-7","volume":"4","author":"CJ Marshall","year":"1994","unstructured":"Marshall CJ (1994) MAPK kinase kinase kinase, MAPK kinase kinase and MAPK kinase. Curr Opin Genet Dev, 4, 82\u201389.","journal-title":"Curr Opin Genet Dev"},{"key":"BFEMBJ7591452_CR38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","volume":"80","author":"CJ Marshall","year":"1995","unstructured":"Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal\u2010regulated kinase activation. Cell, 80, 179\u2013185.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR39","first-page":"3482","volume":"12","author":"M Matsuda","year":"1992","unstructured":"Matsuda M, Tanaka S, Nagata S, Kojima A, Kurata T and Shibuya M (1992) Two species of human CRK cDNA encode proteins with distinct biological activities. Mol Cell Biol, 12, 3482\u20133489.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591452_CR40","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/332272a0","volume":"332","author":"BJ Mayer","year":"1988","unstructured":"Mayer BJ, Hamaguchi M and Hanafusa H (1988) A novel viral oncogene with structural similarity to phospholipase C. Nature, 332, 272\u2013275.","journal-title":"Nature"},{"key":"BFEMBJ7591452_CR41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)80126-9","volume":"86","author":"GLG Miklos","year":"1996","unstructured":"Miklos GLG and Rubin GM (1996) The role of the genome project in determing gene function: insights from model organisms. Cell, 86, 521\u2013529.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR42","first-page":"F85","volume":"1333","author":"A Minden","year":"1997","unstructured":"Minden A and Karin M (1997) Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta, 1333, F85\u2013F104.","journal-title":"Biochim Biophys Acta"},{"key":"BFEMBJ7591452_CR43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1242\/jcs.110.3.389","volume":"110","author":"M Nievers","year":"1997","unstructured":"Nievers M, Birge R, Greulich H, Verkleij A, Hanafusa H and Henegouwen P (1997) v\u2010Crk\u2010induced cell transformation: changes in focal adhesion composition and signaling. J Cell Sci, 110, 389\u2013399.","journal-title":"J Cell Sci"},{"key":"BFEMBJ7591452_CR44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0168-9525(97)01320-6","volume":"14","author":"S Noselli","year":"1998","unstructured":"Noselli S (1998) JNK signaling and morphogenesis in Drosophila. Trends Genet, 14, 33\u201338.","journal-title":"Trends Genet"},{"key":"BFEMBJ7591452_CR45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(93)90170-U","volume":"73","author":"JP Olivier","year":"1993","unstructured":"Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E and Pawson T (1993) A Drosophila SH2\u2013SH3 adaptor protein implicated in coupling the Sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. Cell, 73, 179\u2013191.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR46","doi-asserted-by":"crossref","first-page":"8512","DOI":"10.1073\/pnas.91.18.8512","volume":"91","author":"LA Quilliam","year":"1994","unstructured":"Quilliam LA, Huff SY, Rabun KM, Wei W, Park W, Broek D and Der CJ (1994) Membrane\u2010targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity. Proc Natl Acad Sci USA, 91, 8512\u20138516.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591452_CR47","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81274-X","volume":"85","author":"T Raabe","year":"1996","unstructured":"Raabe T, Riesgo\u2010Escovar J, Liu X, Bausenwein BS, Deak P, Mar\u00f6y P and Hafen E (1996) DOS, a novel pleckstrin homology domain\u2010containing protein required for signal transduction between Sevenless and Ras1 in Drosophila. Cell, 85, 911\u2013920.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0092-8674(94)90104-X","volume":"76","author":"MD Resh","year":"1994","unstructured":"Resh MD (1994) Myristylation and palmitylation of Src family members: the fats of the matter. Cell, 76, 411\u2013413.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/neu.480220503","volume":"22","author":"S Robinow","year":"1991","unstructured":"Robinow S and White K (1991) Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J Neurobiol, 22, 443\u2013461.","journal-title":"J Neurobiol"},{"key":"BFEMBJ7591452_CR50","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1083\/jcb.115.3.587","volume":"115","author":"MB Roth","year":"1991","unstructured":"Roth MB, Zahler AM and Stolk JA (1991) A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J Cell Biol, 115, 587\u2013596.","journal-title":"J Cell Biol"},{"key":"BFEMBJ7591452_CR51","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1002\/j.1460-2075.1994.tb06684.x","volume":"13","author":"R Sakai","year":"1994","unstructured":"Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Mano H, Yazaki Y and Hirai H (1994) A novel signaling molecule, p130, forms stable complexes in vivo with v\u2010Crk and v\u2010Src in a tyrosine phosphorylation\u2010dependent manner. EMBO J, 13, 3748\u20133756.","journal-title":"EMBO J"},{"key":"BFEMBJ7591452_CR52","volume-title":"Molecular Cloning: A Laboratory Manual","author":"J Sambrook","year":"1989","unstructured":"Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"BFEMBJ7591452_CR53","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","volume":"74","author":"F Sanger","year":"1977","unstructured":"Sanger F, Nicklen S and Coulson AR (1977) DNA sequencing with chain\u2010terminating inhibitors. Proc Natl Acad Sci USA, 74, 5463\u20135467.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591452_CR54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0092-8674(93)90169-Q","volume":"73","author":"MA Simon","year":"1993","unstructured":"Simon MA, Dodson GS and Rubin GM (1993) An SH3\u2013SH2\u2013SH3 protein is required for p21Ras1 activation and binds to Sevenless and Sos proteins in vitro. Cell, 73, 169\u2013177.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR55","first-page":"2777","volume":"14","author":"Z Songyang","year":"1994","unstructured":"Songyang Z et al. (1994) Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps\/fes, GRB2, SHC, Syk, and Vav. Mol Cell Biol, 14, 2777\u20132785.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591452_CR56","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/372783a0","volume":"372","author":"K Staehling\u2010Hampton","year":"1994","unstructured":"Staehling\u2010Hampton K, Hoffmann FM, Baylies MK, Rushton E and Bate M (1994) dpp induces mesodermal gene expression in Drosophila. Nature, 372, 783\u2013786.","journal-title":"Nature"},{"key":"BFEMBJ7591452_CR57","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0092-8674(92)90191-E","volume":"68","author":"JW Tamkun","year":"1992","unstructured":"Tamkun JW, Deuring R, Scott MP, Kissinger M, Pattatucci AM, Kaufman TC and Kennison JA (1992) brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2\/SWI2. Cell, 68, 561\u2013572.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR58","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1074\/jbc.273.3.1281","volume":"273","author":"S Tanaka","year":"1998","unstructured":"Tanaka S and Hanafusa H (1998) Guanine\u2010nucleotide exchange protein C3G activates JNK1 by a Ras\u2010independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. J Biol Chem, 273, 1281\u20131284.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591452_CR59","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1073\/pnas.91.8.3443","volume":"91","author":"S Tanaka","year":"1994","unstructured":"Tanaka S et al. (1994) C3G, a guanine nucleotide\u2010releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2\/ASH proteins. Proc Natl Acad Sci USA, 91, 3443\u20133447.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591452_CR60","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1073\/pnas.94.6.2356","volume":"94","author":"S Tanaka","year":"1997","unstructured":"Tanaka S, Ouchi T and Hanafusa H (1997) Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v\u2010Crk through the guanine nucleotide exchange protein C3G. Proc Natl Acad Sci USA, 94, 2356\u20132361.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591452_CR61","doi-asserted-by":"crossref","first-page":"20677","DOI":"10.1074\/jbc.270.35.20677","volume":"270","author":"K Teng","year":"1995","unstructured":"Teng K, Lander H, Fajardo JE, Hanafusa H, Hempstead BL and Birge RB (1995) v\u2010Crk modulation of growth factor\u2010induced PC12 cell differentiation involves the Src homology 2 domain of v\u2010Crk and sustained activation of the Ras\/mitogen\u2010activated protein kinase pathway. J Biol Chem, 270, 20677\u201320685.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591452_CR62","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0092-8674(95)90204-X","volume":"83","author":"M Therrien","year":"1995","unstructured":"Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA and Rubin GM (1995) KSR, a novel protein kinase required for RAS signal transduction. Cell, 83, 879\u2013888.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0012-1606(87)90448-9","volume":"120","author":"A Tomlinson","year":"1987","unstructured":"Tomlinson A and Ready DF (1987) Neuronal differentiation in the Drosophila ommatidium. Dev Biol, 120, 264\u2013275.","journal-title":"Dev Biol"},{"key":"BFEMBJ7591452_CR64","first-page":"160","volume":"52","author":"S van der Meer","year":"1977","unstructured":"van der Meer S (1977) Optical clean and permanent whole mount preparation for phase contrast microscopy of cuticular structures of insect larvae. Drosophila Inf Serv, 52, 160\u2013161.","journal-title":"Drosophila Inf Serv"},{"key":"BFEMBJ7591452_CR65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)80184-1","volume":"89","author":"MR Vossler","year":"1997","unstructured":"Vossler MR, Yao H, York RD, Pan MG, Rim CS and Stork PJ (1997) cAMP activates MAP kinase and Elk\u20101 through a B\u2010Raf\u2010 and Rap1\u2010dependent pathway. Cell, 89, 73\u201382.","journal-title":"Cell"},{"key":"BFEMBJ7591452_CR66","first-page":"1","volume":"5","author":"DA Wassarman","year":"1997","unstructured":"Wassarman DA and Therrien M (1997) RAS1\u2010mediated photoreceptor development in Drosophila. Adv Dev Biol, 5, 1\u201341.","journal-title":"Adv Dev Biol"},{"key":"BFEMBJ7591452_CR67","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/33451","volume":"392","author":"RD York","year":"1998","unstructured":"York RD, Yao H, Dilon T, Ellig CL, Eckert SP, McCleskey EW and Stork PJ (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature, 392, 622\u2013626.","journal-title":"Nature"},{"key":"BFEMBJ7591452_CR68","first-page":"3407","volume":"12","author":"Y Yoshida","year":"1992","unstructured":"Yoshida Y, Kawata M, Miura Y, Musha T, Sasaki T, Kikuchi A and Takai Y (1992) Microinjection of smg\/rap1\/Krev\u20101 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Mol Cell Biol, 12, 3407\u20133414.","journal-title":"Mol Cell Biol"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2F18.1.145","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/18.1.145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/18.1.145\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/18.1.145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/18.1.145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:06:42Z","timestamp":1779300402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/18.1.145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,4]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1,4]]}},"alternative-id":["BFEMBJ7591452"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/18.1.145","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1,4]]},"assertion":[{"value":"28 July 1998","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 1998","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 1998","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 1999","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}