{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:22:33Z","timestamp":1791145353364,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1999,6,15]],"date-time":"1999-06-15T00:00:00Z","timestamp":929404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1999,6,15]],"date-time":"1999-06-15T00:00:00Z","timestamp":929404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[1999,6,15]]},"DOI":"10.1093\/emboj\/18.12.3491","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:44:48Z","timestamp":1027709088000},"page":"3491-3501","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":374,"title":["Xeroderma pigmentosum variant (XP\u2010V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity"],"prefix":"10.1038","volume":"18","author":[{"given":"Chikahide","family":"Masutani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marito","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Kusumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Nogimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1999,6,15]]},"reference":[{"key":"BFEMBJ7591767_CR1","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1074\/jbc.272.8.4647","volume":"272","author":"RA Bambara","year":"1997","unstructured":"Bambara RA, Murante RS and Henricksen LA (1997) Enzymes and reactions at the eukaryotic DNA replication fork. J Biol Chem, 272, 4647\u20134650.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591767_CR2","first-page":"245","volume-title":"The Genetic Basis of Human Cancer","author":"D Bootsma","year":"1998","unstructured":"Bootsma D, Kraemer KH, Cleaver J and Hoeijmakers JHJ (1998) Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. In Vogelstein,B. and Kinzler,K.W. (eds), The Genetic Basis of Human Cancer. McGraw\u2010Hill Book Co., New York, NY, pp. 245\u2013274."},{"key":"BFEMBJ7591767_CR3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein\u2010dye binding. Anal Biochem, 72, 248\u2013254.","journal-title":"Anal Biochem"},{"key":"BFEMBJ7591767_CR4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s004120050300","volume":"107","author":"PM Burgers","year":"1998","unstructured":"Burgers PM (1998) Eukaryotic DNA polymerases in DNA replication and DNA repair. Chromosoma, 107, 218\u2013227.","journal-title":"Chromosoma"},{"key":"BFEMBJ7591767_CR5","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1074\/jbc.271.16.9637","volume":"271","author":"MP Carty","year":"1996","unstructured":"Carty MP, Lawrence CW and Dixon K (1996) Complete replication of plasmid DNA containing a single UV\u2010induced lesion in human cell extracts. J Biol Chem, 271, 9637\u20139647.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591767_CR6","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1074\/jbc.272.21.13945","volume":"272","author":"M Cordeiro\u2010Stone","year":"1997","unstructured":"Cordeiro\u2010Stone M, Zaritskaya LS, Price LK and Kaufmann WK (1997) Replication fork bypass of a pyrimidine dimer blocking leading strand DNA synthesis. J Biol Chem, 272, 13945\u201313954.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591767_CR7","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/MCB.19.3.2206","volume":"19","author":"AM Cordonnier","year":"1999","unstructured":"Cordonnier AM, Lehmann AR and Fuchs RP (1999) Impaired translesion synthesis in xeroderma pigmentosum variant extracts. Mol Cell Biol, 19, 2206\u20132211.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591767_CR8","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1074\/jbc.272.4.2559","volume":"272","author":"E Efrati","year":"1997","unstructured":"Efrati E, Tocco G, Eritja R, Wilson SH and Goodman MF (1997) Abasic translesion synthesis by DNA polymerase \u03b2 violates the\u2018A\u2010rule\u2019. J Biol Chem, 272, 2559\u20132569.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591767_CR9","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1128\/jvi.65.9.4874-4881.1991","volume":"65","author":"T Eki","year":"1991","unstructured":"Eki T, Enomoto T, Masutani C, Miyajima A, Takada R, Murakami Y, Ohno T, Hanaoka F and Ui M (1991) Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. J Virol, 65, 4874\u20134881.","journal-title":"J Virol"},{"key":"BFEMBJ7591767_CR10","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.1021\/bi972460j","volume":"37","author":"I Ensch\u2010Simon","year":"1998","unstructured":"Ensch\u2010Simon I, Burgers PMJ and Taylor J\u2010S (1998) Bypass of a site\u2010specific cis\u2013syn thymine dimer in an SV40 vector during in vitro replication by HeLa and XPV cell\u2010free extracts. Biochemistry, 37, 8218\u20138226.","journal-title":"Biochemistry"},{"key":"BFEMBJ7591767_CR11","first-page":"155","volume":"12","author":"K Fien","year":"1992","unstructured":"Fien K and Stillman B (1992) Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading\u2010strand DNA replication complex. Mol Cell Biol, 12, 155\u2013163.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591767_CR12","volume-title":"DNA repair and mutagenesis","author":"EC Friedberg","year":"1995","unstructured":"Friedberg EC, Walker GC and Siede W (1995) DNA repair and mutagenesis. ASM press, Washington, DC."},{"key":"BFEMBJ7591767_CR13","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1073\/pnas.95.12.6876","volume":"95","author":"PE Gibbs","year":"1998","unstructured":"Gibbs PE, McGregor WG, Maher VM, Nisson P and Lawrence CW (1998) A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase \u03b6. Proc Natl Acad Sci USA, 95, 6876\u20136880.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591767_CR14","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1073\/pnas.92.12.5356","volume":"92","author":"JS Hoffmann","year":"1995","unstructured":"Hoffmann JS, Pillaire MJ, Maga G, Podust V, Hubscher U and Villani G (1995) DNA polymerase \u03b2 bypasses in vitro a single d (GpG)\u2010cisplatin adduct placed on codon 13 of the HRAS gene. Proc Natl Acad Sci USA, 92, 5356\u20135360.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591767_CR15","doi-asserted-by":"crossref","first-page":"15386","DOI":"10.1074\/jbc.271.26.15386","volume":"271","author":"JS Hoffmann","year":"1996","unstructured":"Hoffmann JS, Pillaire MJ, Garacia Estefania D, Lapalu S and Villani G (1996) In vitro bypass replication of the cisplatin\u2010d(GpG) lesion by calf thymus DNA polymerase \u03b2 and human immunodeficiency virus type\u2010I reverse transcriptase is highly mutagenic. J Biol Chem, 271, 15386\u201315392.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591767_CR16","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1021\/ja9603158","volume":"118","author":"S Iwai","year":"1996","unstructured":"Iwai S, Shimizu M, Kamiya H and Ohtsuka E (1996) Synthesis of a phosphoramidite coupling unit of the pyrimidine (6\u20104) pyrimidone photoproduct and its incorporation into oligodeoxynucleotides. J Am Chem Soc, 118, 7642\u20137643.","journal-title":"J Am Chem Soc"},{"key":"BFEMBJ7591767_CR17","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.283.5404.1001","volume":"283","author":"RE Johnson","year":"1999","unstructured":"Johnson RE, Prakash S and Prakash L (1999) Efficient bypass of a thymine\u2013thymine dimer by yeast DNA polymerase, pol\u03b7. Science, 283, 1001\u20131004.","journal-title":"Science"},{"key":"BFEMBJ7591767_CR18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680\u2013685.","journal-title":"Nature"},{"key":"BFEMBJ7591767_CR19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/bies.950160408","volume":"16","author":"C Lawrence","year":"1994","unstructured":"Lawrence C (1994) The RAD6 DNA repair pathway in Saccharomyces cerevisiae: what does it do and how does it do it? BioEssays, 16, 253\u2013258.","journal-title":"BioEssays"},{"key":"BFEMBJ7591767_CR20","first-page":"21","volume":"28","author":"CW Lawrence","year":"1996","unstructured":"Lawrence CW and Hinkle DC (1996) DNA polymerase \u03b6 and the control of DNA damage induced mutagenesis in eukaryotes. Cancer Surv, 28, 21\u201331.","journal-title":"Cancer Surv"},{"key":"BFEMBJ7591767_CR21","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1016\/S0021-9258(18)86932-0","volume":"265","author":"C Masutani","year":"1990","unstructured":"Masutani C, Enomoto T, Suzuki M, Hanaoka F and Ui M (1990) DNA primase stimulatory factor from mouse FM3A cells has an RNase H activity. J Biol Chem, 265, 10210\u201310216.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7591767_CR22","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/genetics\/147.4.1557","volume":"147","author":"JP McDonald","year":"1997","unstructured":"McDonald JP, Levine AS and Woodgate R (1997) The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error\u2010free postreplication repair mechanism. Genetics, 147, 1557\u20131568.","journal-title":"Genetics"},{"key":"BFEMBJ7591767_CR23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/MCB.19.1.147","volume":"19","author":"WG McGregor","year":"1999","unstructured":"McGregor WG, Wei D, Maher VM and McCormick JJ (1999) Abnormal, error\u2010prone bypass of photoproducts by xeroderma pigmentosum variant cell extracts results in extreme strand bias for the kinds of mutations induced by UV light. Mol Cell Biol, 19, 147\u2013154.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591767_CR24","first-page":"1002","volume":"13","author":"RR Misra","year":"1993","unstructured":"Misra RR and Vos JM (1993) Defective replication of psoralen adducts detected at the gene\u2010specific level in xeroderma pigmentosum variant cells. Mol Cell Biol, 13, 1002\u20131012.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591767_CR25","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1073\/pnas.94.12.6126","volume":"94","author":"DJ Mozzherin","year":"1997","unstructured":"Mozzherin DJ, Shibutani S, Tan C\u2010K, Downey KM and Fisher PA (1997) Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase \u03b4. Proc Natl Acad Sci USA, 94, 6126\u20136131.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591767_CR26","doi-asserted-by":"crossref","first-page":"7279","DOI":"10.1093\/nar\/18.24.7279","volume":"18","author":"T Murata","year":"1990","unstructured":"Murata T, Iwai S and Ohtsuka E (1990) Synthesis and characterization of a substrate for T4 endonuclease V containing a phosphorodithioate linkage at the thymine dimer site. Nucleic Acids Res, 18, 7279\u20137286.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7591767_CR27","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1126\/science.272.5268.1646","volume":"272","author":"JR Nelson","year":"1996","unstructured":"Nelson JR, Lawrence CW and Hinkle DC (1996a) Thymine\u2013thymine dimer bypass by yeast DNA polymerase \u03b6. Science, 272, 1646\u20131649.","journal-title":"Science"},{"key":"BFEMBJ7591767_CR28","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/382729a0","volume":"382","author":"JR Nelson","year":"1996","unstructured":"Nelson JR, Lawrence CW and Hinkle DC (1996b) Deoxycytidyl transferase activity of yeast REV1 protein. Nature, 382, 729\u2013731.","journal-title":"Nature"},{"key":"BFEMBJ7591767_CR29","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1093\/nar\/20.20.5403","volume":"20","author":"CL O'Day","year":"1992","unstructured":"O'Day CL, Burgers PM and Taylor JS (1992) PCNA\u2010induced DNA synthesis past cis\u2013syn and trans\u2013syn\u2010I thymine dimers by calf thymus DNA polymerase \u03b4 in vitro. Nucleic Acids Res, 20, 5403\u20135406.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7591767_CR30","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/genetics\/96.4.819","volume":"96","author":"SK Quah","year":"1980","unstructured":"Quah SK, von Borstel RC and Hastings PJ (1980) The origin of spontaneous mutation in Saccharomyces cerevisiae. Genetics, 96, 819\u2013839.","journal-title":"Genetics"},{"key":"BFEMBJ7591767_CR31","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s004380050698","volume":"257","author":"AA Roush","year":"1998","unstructured":"Roush AA, Suarez M, Friedberg EC, Radman M and Siede W (1998) Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability. Mol Gen Genet, 257, 686\u2013692.","journal-title":"Mol Gen Genet"},{"key":"BFEMBJ7591767_CR32","doi-asserted-by":"crossref","first-page":"11975","DOI":"10.1073\/pnas.92.26.11975","volume":"92","author":"DL Svoboda","year":"1995","unstructured":"Svoboda DL and Vos J\u2010MH (1995) Differential replication of a single, UV\u2010induced lesion in the leading or lagging strand by a human cell extract: fork uncoupling or gap formation. Proc Natl Acad Sci USA, 92, 11975\u201311979.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591767_CR33","first-page":"2445","volume":"58","author":"DL Svoboda","year":"1998","unstructured":"Svoboda DL, Briley LP and Vos J\u2010MH (1998) Defective bypass replication of a leading strand cyclobutane thymine dimer in xeroderma pigmentosum variant cell extracts. Cancer Res, 58, 2445\u20132448.","journal-title":"Cancer Res"},{"key":"BFEMBJ7591767_CR34","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.biochem.67.1.721","volume":"67","author":"S Waga","year":"1998","unstructured":"Waga S and Stillman B (1998) The DNA replication fork in eukaryotic cells. Annu Rev Biochem, 67, 721\u2013751.","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ7591767_CR35","doi-asserted-by":"crossref","first-page":"7810","DOI":"10.1073\/pnas.88.17.7810","volume":"88","author":"YC Wang","year":"1991","unstructured":"Wang YC, Maher VM and McCormick JJ (1991) Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV\u2010irradiated plasmids. Proc Natl Acad Sci USA, 88, 7810\u20137814.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7591767_CR36","first-page":"4276","volume":"13","author":"Y\u2010C Wang","year":"1993","unstructured":"Wang Y\u2010C, Maher VM, Mitchell DL and McCormick JJ (1993) Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error\u2010prone replication on a template containing photoproducts. Mol Cell Biol, 13, 4276\u20137283.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7591767_CR37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/carcin\/18.4.605","volume":"18","author":"RD Wood","year":"1997","unstructured":"Wood RD and Shivji MKK (1997) Which DNA polymerases are used for DNA\u2010repair in eukaryotes? Carcinogenesis, 18, 605\u2013610.","journal-title":"Carcinogenesis"},{"key":"BFEMBJ7591767_CR38","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/carcin\/19.5.945","volume":"19","author":"W Xiao","year":"1998","unstructured":"Xiao W, Lechler T, Chow BL, Fontanie T, Agustus M, Carter KC and Wei YF (1998) Identification, chromosomal mapping and tissue\u2010specific expression of hREV3 encoding a putative human DNA polymerase \u03b6. Carcinogenesis, 19, 945\u2013949.","journal-title":"Carcinogenesis"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2F18.12.3491","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/18.12.3491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/18.12.3491\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/18.12.3491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/18.12.3491.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:15:01Z","timestamp":1779300901000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/18.12.3491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,15]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,6,15]]}},"alternative-id":["BFEMBJ7591767"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/18.12.3491","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6,15]]},"assertion":[{"value":"6 April 1999","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 1999","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 1999","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 1999","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}