{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:02:59Z","timestamp":1791216179048,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2002,3,1]]},"DOI":"10.1093\/emboj\/21.5.1092","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:37:51Z","timestamp":1027708671000},"page":"1092-1100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":177,"title":["Limited demethylation leaves mosaic\u2010type methylation states in cloned bovine pre\u2010implantation embryos"],"prefix":"10.1038","volume":"21","author":[{"given":"Yong\u2010Kook","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Sun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deog\u2010Bon","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun\u2010Uk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Kwang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Mahn","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"BFEMBJ7594327_CR1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/0092-8674(90)90195-K","volume":"61","author":"ND Allen","year":"1990","unstructured":"Allen ND, Norris ML and Surani MA (1990) Epigenetic control of transgene expression and imprinting by genotype\u2010specific modifiers. Cell, 61, 853\u2013861.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/1097-010X(20010201)289:2<139::AID-JEZ7>3.0.CO;2-6","volume":"289","author":"T Amano","year":"2001","unstructured":"Amano T, Tani T, Kato Y and Tsunoda Y (2001) Mouse cloned from embryonic stem (ES) cells synchronized in metaphase with nocodazole. J Exp Zool, 289, 139\u2013145.","journal-title":"J Exp Zool"},{"key":"BFEMBJ7594327_CR3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ng0395-312","volume":"9","author":"M Ariel","year":"1995","unstructured":"Ariel M, Robinson E, McCarrey JR and Cedar H (1995) Gamete\u2010specific methylation correlates with imprinting of the murine Xist gene. Nature Genet, 9, 312\u2013315.","journal-title":"Nature Genet"},{"key":"BFEMBJ7594327_CR4","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1086\/301891","volume":"62","author":"TH Bestor","year":"1998","unstructured":"Bestor TH (1998) Cytosine methylation and the unequal developmental potentials of the oocyte and sperm genomes. Am J Hum Genet, 62, 1269\u20131273.","journal-title":"Am J Hum Genet"},{"key":"BFEMBJ7594327_CR5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","volume":"321","author":"AP Bird","year":"1986","unstructured":"Bird AP (1986) CpG\u2010rich islands and the function of DNA methylation. Nature, 321, 209\u2013213.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR6","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0960-9822(01)00480-8","volume":"11","author":"D Bourc'his","year":"2001","unstructured":"Bourc'his D, Le Bourhis D, Patin D, Niveleau A, Comizzoli P, Renard J and Viegas\u2010Pequignot E (2001) Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos. Curr Biol, 11, 1542\u20131546.","journal-title":"Curr Biol"},{"key":"BFEMBJ7594327_CR7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/380064a0","volume":"380","author":"KH Campbell","year":"1996","unstructured":"Campbell KH, McWhir J, Ritchie WA and Wilmut I (1996) Sheep cloned by nuclear transfer from a cultured cell line. Nature, 380, 64\u201366.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0092-8674(91)90140-T","volume":"66","author":"JR Chaillet","year":"1991","unstructured":"Chaillet JR, Vogt TF, Beier DR and Leder P (1991) Parental\u2010specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell, 66, 77\u201383.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/307284a0","volume":"307","author":"V Chapman","year":"1984","unstructured":"Chapman V, Forrester L, Sanford J, Hastie N and Rossant J (1984) Cell lineage\u2010specific undermethylation of mouse repetitive DNA. Nature, 307, 284\u2013286.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR10","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1126\/science.280.5367.1256","volume":"280","author":"JB Cibelli","year":"1998","unstructured":"Cibelli JB, Stice SL, Golueke PJ, Kane JJ, Jerry J, Blackwell C, Ponce de Leon FA and Robl JM (1998) Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science, 280, 1256\u20131258.","journal-title":"Science"},{"key":"BFEMBJ7594327_CR11","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1073\/pnas.241522698","volume":"98","author":"W Dean","year":"2001","unstructured":"Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E and Reik W (2001) Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci USA, 98, 13734\u201313738.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7594327_CR12","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1073\/pnas.101118898","volume":"98","author":"K Eggan","year":"2001","unstructured":"Eggan K, Akutsu H, Loring J, Jackson\u2010Grusby L, Klemm M, Rideout WM,III, Yanagimachi R and Jaenisch R (2001) Hybrid vigor, fetal overgrowth and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc Natl Acad Sci USA, 98, 6209\u20136214.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMBJ7594327_CR13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/371333a0","volume":"371","author":"F Guillemot","year":"1994","unstructured":"Guillemot F, Nagy A, Auerbach A, Rossant J and Joyner AL (1994) Essential role of Mash\u20102 in extraembryonic development. Nature, 371, 333\u2013336.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/45429","volume":"402","author":"JB Gurdon","year":"1999","unstructured":"Gurdon JB and Colman A (1999) The future of cloning. Nature, 402, 743\u2013746.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR15","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0093-691X(99)00089-8","volume":"51","author":"JR Hill","year":"1999","unstructured":"Hill JR et al. (1999) Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies). Theriogenology, 51, 1451\u20131465.","journal-title":"Theriogenology"},{"key":"BFEMBJ7594327_CR16","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1095\/biolreprod62.5.1135","volume":"62","author":"JR Hill","year":"2000","unstructured":"Hill JR, Winger QA, Long CR, Looney CR, Thompson JA and Westhusin ME (2000) Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells. Biol Reprod, 62, 1135\u20131140.","journal-title":"Biol Reprod"},{"key":"BFEMBJ7594327_CR17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1242\/dev.113.1.119","volume":"113","author":"SK Howlett","year":"1991","unstructured":"Howlett SK and Reik W (1991) Methylation levels of maternal and paternal genomes during preimplantation development. Development, 113, 119\u2013127.","journal-title":"Development"},{"key":"BFEMBJ7594327_CR18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.1061402","volume":"293","author":"D Humpherys","year":"2001","unstructured":"Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM,III, Biniszkiewicz D, Yanagimachi R and Jaenisch R (2001) Epigenetic instability in ES cells and cloned mice. Science, 293, 95\u201397.","journal-title":"Science"},{"key":"BFEMBJ7594327_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(01)02472-3","volume":"498","author":"YK Kang","year":"2001","unstructured":"Kang YK, Koo D, Park JS, Choi Y, Lee K and Han Y (2001a) Differential inheritance modes of DNA methylation between euchromatic and heterochromatic DNA sequences in ageing fetal bovine fibroblasts. FEBS Lett, 498, 1\u20135.","journal-title":"FEBS Lett"},{"key":"BFEMBJ7594327_CR20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-5793(01)02514-5","volume":"499","author":"YK Kang","year":"2001","unstructured":"Kang YK, Koo D, Park JS, Choi Y, Lee K and Han Y (2001b) Influence of the oocyte nuclei on demethylation of donor genome in cloned bovine embryos. FEBS Lett, 499, 55\u201358.","journal-title":"FEBS Lett"},{"key":"BFEMBJ7594327_CR21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/88903","volume":"28","author":"YK Kang","year":"2001","unstructured":"Kang YK, Koo DB, Park JS, Choi YH, Chung AS, Lee KK and Han YM (2001c) Aberrant methylation of donor genome in cloned bovine embryos. Nature Genet, 28, 173\u2013177.","journal-title":"Nature Genet"},{"key":"BFEMBJ7594327_CR22","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.288.5466.665","volume":"288","author":"RP Lanza","year":"2000","unstructured":"Lanza RP et al. (2000) Extension of cell life\u2010span and telomere length in animals cloned from senescent somatic cells. Science, 288, 665\u2013669.","journal-title":"Science"},{"key":"BFEMBJ7594327_CR23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/HUMREP\/11.3.598","volume":"11","author":"G Leppens","year":"1996","unstructured":"Leppens G, Gardner DK and Sakkas D (1996) Co\u2010culture of 1\u2010cell outbred mouse embryos on bovine kidney epithelial cells: effect on development, glycolytic activity, inner cell mass:trophectoderm ratios and viability. Hum Reprod, 11, 598\u2013603.","journal-title":"Hum Reprod"},{"key":"BFEMBJ7594327_CR24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","volume":"69","author":"E Li","year":"1992","unstructured":"Li E, Bestor TH and Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell, 69, 915\u2013926.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1095\/biolreprod59.2.451","volume":"59","author":"Z Machaty","year":"1998","unstructured":"Machaty Z, Day BN and Prather RS (1998) Development of early porcine embryos in vitro and in vivo. Biol Reprod, 59, 451\u2013455.","journal-title":"Biol Reprod"},{"key":"BFEMBJ7594327_CR26","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/293589a0","volume":"293","author":"C Manes","year":"1981","unstructured":"Manes C and Menzel P (1981) Demethylation of CpG sites in DNA of early rabbit trophoblast. Nature, 293, 589\u2013590.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/35000656","volume":"403","author":"W Mayer","year":"2000","unstructured":"Mayer W, Niveleau A, Walter J, Fundele R and Haaf T (2000) Demethylation of the zygotic paternal genome. Nature, 403, 501\u2013502.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1242\/dev.99.3.371","volume":"99","author":"M Monk","year":"1987","unstructured":"Monk M, Boubelik M and Lehnert S (1987) Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development, 99, 371\u2013382.","journal-title":"Development"},{"key":"BFEMBJ7594327_CR29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/gene.1031","volume":"30","author":"J Ohgane","year":"2001","unstructured":"Ohgane J, Wakayama T, Kogo Y, Senda S, Hattori N, Tanaka S, Yanagimachi R and Shiota K (2001) DNA methylation variation in cloned mice. Genesis, 30, 45\u201350.","journal-title":"Genesis"},{"key":"BFEMBJ7594327_CR30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","volume":"99","author":"M Okano","year":"1999","unstructured":"Okano M, Bell DW, Haber DA and Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, 247\u2013257.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1095\/biolreprod64.1.44","volume":"64","author":"Y Ono","year":"2001","unstructured":"Ono Y, Shimozawa N, Ito M and Kono T (2001) Cloned mice from fetal fibroblast cells arrested at metaphase by a serial nuclear transfer. Biol Reprod, 64, 44\u201350.","journal-title":"Biol Reprod"},{"key":"BFEMBJ7594327_CR32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0960-9822(00)00448-6","volume":"10","author":"J Oswald","year":"2000","unstructured":"Oswald J, Engemann S, Lane N, Mayer W, Olek A, Fundele R, Dean W, Reik W and Walter J (2000) Active demethylation of the paternal genome in the mouse zygote. Curr Biol, 10, 475\u2013478.","journal-title":"Curr Biol"},{"key":"BFEMBJ7594327_CR33","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1210\/endo.134.1.8275935","volume":"134","author":"S Pampfer","year":"1994","unstructured":"Pampfer S, Wuu YD, Vanderheyden I and De Hertogh R (1994) Expression of tumor necrosis factor\u2010\u03b1 (TNF \u03b1) receptors and selective effect of TNF \u03b1 on the inner cell mass in mouse blastocysts. Endocrinology, 134, 206\u2013212.","journal-title":"Endocrinology"},{"key":"BFEMBJ7594327_CR34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(94)90208-9","volume":"77","author":"A Razin","year":"1994","unstructured":"Razin A and Cedar H (1994) DNA methylation and genomic imprinting. Cell, 77, 473\u2013476.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR35","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/hmg\/4.suppl_1.1751","volume":"4","author":"A Razin","year":"1995","unstructured":"Razin A and Shemer R (1995) DNA methylation in early development. Hum Mol Genet, 4, 1751\u20131755.","journal-title":"Hum Mol Genet"},{"key":"BFEMBJ7594327_CR36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0012-1606(89)90319-9","volume":"133","author":"LJ Regenstreif","year":"1989","unstructured":"Regenstreif LJ and Rossant J (1989) Expression of the c\u2010fms proto\u2010oncogene and of the cytokine, CSF\u20101, during mouse embryogenesis. Dev Biol, 133, 284\u2013294.","journal-title":"Dev Biol"},{"key":"BFEMBJ7594327_CR37","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780199636266.001.0001","volume-title":"Genomic Imprinting","author":"W Reik","year":"1997","unstructured":"Reik W and Surani A (1997) Genomic Imprinting. IRL Press, Oxford, UK."},{"key":"BFEMBJ7594327_CR38","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1242\/dev.119.3.933","volume":"119","author":"W Reik","year":"1993","unstructured":"Reik W, Romer I, Barton SC, Surani MA, Howlett SK and Klose J (1993) Adult phenotype in the mouse can be affected by epigenetic events in the early embryo. Development, 119, 933\u2013942.","journal-title":"Development"},{"key":"BFEMBJ7594327_CR39","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1095\/biolreprod49.3.459","volume":"49","author":"Jr CF Rosenkrans","year":"1993","unstructured":"Rosenkrans CF,Jr, Zeng GQ, McNamara GT, Schoff PK and First NL (1993) Development of bovine embryos in vitro as affected by energy substrates. Biol Reprod, 49, 459\u2013462.","journal-title":"Biol Reprod"},{"key":"BFEMBJ7594327_CR40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0012-1606(86)90325-8","volume":"117","author":"J Rossant","year":"1986","unstructured":"Rossant J, Sanford JP, Chapman VM and Andrews GK (1986) Undermethylation of structural gene sequences in extraembryonic lineages of the mouse. Dev Biol, 117, 567\u2013573.","journal-title":"Dev Biol"},{"key":"BFEMBJ7594327_CR41","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1101\/gad.12.14.2108","volume":"12","author":"N Rougier","year":"1998","unstructured":"Rougier N, Bourc'his D, Gomes DM, Niveleau A, Plachot M, Paldi A and Viegas\u2010Pequignot E (1998) Chromosome methylation patterns during mammalian preimplantation development. Genes Dev, 12, 2108\u20132113.","journal-title":"Genes Dev"},{"key":"BFEMBJ7594327_CR42","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1242\/dev.107.1.165","volume":"107","author":"C Sapienza","year":"1989","unstructured":"Sapienza C, Paquette J, Tran TH and Peterson A (1989) Epigenetic and genetic factors affect transgene methylation imprinting. Development, 107, 165\u2013168.","journal-title":"Development"},{"key":"BFEMBJ7594327_CR43","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1126\/science.278.5346.2130","volume":"278","author":"AE Schnieke","year":"1997","unstructured":"Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M, Wilmut I, Colman A and Campbell KH (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science, 278, 2130\u20132133.","journal-title":"Science"},{"key":"BFEMBJ7594327_CR44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/35042066","volume":"1","author":"D Solter","year":"2000","unstructured":"Solter D (2000) Mammalian cloning: advances and limitations. Nature Rev Genet, 1, 199\u2013207.","journal-title":"Nature Rev Genet"},{"key":"BFEMBJ7594327_CR45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0092-8674(93)90160-R","volume":"73","author":"R Stoger","year":"1993","unstructured":"Stoger R, Kubicka P, Liu CG, Kafri T, Razin A, Cedar H and Barlow DP (1993) Maternal\u2010specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell, 73, 61\u201371.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR46","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0092-8674(92)90503-5","volume":"71","author":"S Strickland","year":"1992","unstructured":"Strickland S and Richards WG (1992) Invasion of the trophoblasts. Cell, 71, 355\u2013357.","journal-title":"Cell"},{"key":"BFEMBJ7594327_CR47","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng0495-407","volume":"9","author":"KD Tremblay","year":"1995","unstructured":"Tremblay KD, Saam JR, Ingram RS, Tilghman SM and Bartolomei MS (1995) A paternal\u2010specific methylation imprint marks the alleles of the mouse H19 gene. Nature Genet, 9, 407\u2013413.","journal-title":"Nature Genet"},{"key":"BFEMBJ7594327_CR48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jez.1402400115","volume":"240","author":"Y Tsunoda","year":"1986","unstructured":"Tsunoda Y, Yasui T, Nakamura K, Uchida T and Sugie T (1986) Effect of cutting the zona pellucida on the pronuclear transplantation in the mouse. J Exp Zool, 240, 119\u2013125.","journal-title":"J Exp Zool"},{"key":"BFEMBJ7594327_CR49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1242\/dev.102.1.127","volume":"102","author":"S Varmuza","year":"1988","unstructured":"Varmuza S, Prideaux V, Kothary R and Rossant J (1988) Polytene chromosomes in mouse trophoblast giant cells. Development, 102, 127\u2013134.","journal-title":"Development"},{"key":"BFEMBJ7594327_CR50","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/28615","volume":"394","author":"T Wakayama","year":"1998","unstructured":"Wakayama T, Perry AC, Zuccotti M, Johnson KR and Yanagimachi R (1998) Full\u2010term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature, 394, 369\u2013374.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR51","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1093\/nar\/25.21.4422","volume":"25","author":"PM Warnecke","year":"1997","unstructured":"Warnecke PM, Stirzaker C, Melki JR, Millar DS, Paul CL and Clark SJ (1997) Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite\u2010treated DNA. Nucleic Acids Res, 25, 4422\u20134426.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7594327_CR52","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/geno.1998.5371","volume":"51","author":"PM Warnecke","year":"1998","unstructured":"Warnecke PM, Mann JR, Frommer M and Clark SJ (1998) Bisulfite sequencing in preimplantation embryos: DNA methylation profile of the upstream region of the mouse imprinted H19 gene. Genomics, 51, 182\u2013190.","journal-title":"Genomics"},{"key":"BFEMBJ7594327_CR53","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1095\/biolreprod57.2.385","volume":"57","author":"DN Wells","year":"1997","unstructured":"Wells DN, Misica PM, Day TA and Tervit HR (1997) Production of cloned lambs from an established embryonic cell line: a comparison between in vivo\u2010 and in vitro\u2010matured cytoplasts. Biol Reprod, 57, 385\u2013393.","journal-title":"Biol Reprod"},{"key":"BFEMBJ7594327_CR54","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/385810a0","volume":"385","author":"I Wilmut","year":"1997","unstructured":"Wilmut I, Schnieke AE, McWhir J, Kind AJ and Campbell KH (1997) Viable offspring derived from fetal and adult mammalian cells. Nature, 385, 810\u2013813.","journal-title":"Nature"},{"key":"BFEMBJ7594327_CR55","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0093-691X(99)00263-0","volume":"53","author":"LE Young","year":"2000","unstructured":"Young LE and Fairburn HR (2000) Improving the safety of embryo technologies: possible role of genomic imprinting. Theriogenology, 53, 627\u2013648.","journal-title":"Theriogenology"},{"key":"BFEMBJ7594327_CR56","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/84769","volume":"27","author":"LE Young","year":"2001","unstructured":"Young LE et al. (2001) Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nature Genet, 27, 153\u2013154.","journal-title":"Nature Genet"},{"key":"BFEMBJ7594327_CR57","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng0395-316","volume":"9","author":"M Zuccotti","year":"1995","unstructured":"Zuccotti M and Monk M (1995) Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X\u2010inactivation. Nature Genet, 9, 316\u2013320.","journal-title":"Nature Genet"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2F21.5.1092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/21.5.1092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/21.5.1092\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/21.5.1092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/21.5.1092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:00:22Z","timestamp":1779303622000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/21.5.1092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["BFEMBJ7594327"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/21.5.1092","relation":{},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]},"assertion":[{"value":"16 October 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2002","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}