{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:16:26Z","timestamp":1791220586128,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,1,2]],"date-time":"2003-01-02T00:00:00Z","timestamp":1041465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,1,2]],"date-time":"2003-01-02T00:00:00Z","timestamp":1041465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO J"],"published-print":{"date-parts":[[2003,1,2]]},"DOI":"10.1093\/emboj\/cdg016","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T11:58:57Z","timestamp":1041076737000},"page":"164-173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":129,"title":["Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase"],"prefix":"10.1038","volume":"22","author":[{"given":"Yuichiro","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigenori","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Sugasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,1,2]]},"reference":[{"key":"BFEMBJ7594926_CR1","doi-asserted-by":"crossref","first-page":"18665","DOI":"10.1074\/jbc.M100855200","volume":"276","author":"M Araki","year":"2001","unstructured":"Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, Ohkuma Y and Hanaoka F (2001) Centrosome protein centrin 2\/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem, 276, 18665\u201318672.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1101\/gad.14.3.349","volume":"14","author":"SJ Ara\u00fajo","year":"2000","unstructured":"Ara\u00fajo SJ, Tirode F, Coin F, Pospiech H, Syv\u00e4oja JE, Stucki M, H\u00fcbscher U, Egly J\u2010M and Wood RD (2000) Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH and modulation by CAK. Genes Dev, 14, 349\u2013359.","journal-title":"Genes Dev"},{"key":"BFEMBJ7594926_CR3","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1128\/MCB.21.7.2281-2291.2001","volume":"21","author":"SJ Ara\u00fajo","year":"2001","unstructured":"Ara\u00fajo SJ, Nigg EA and Wood RD (2001) Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol Cell Biol, 21, 2281\u20132291.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7594926_CR4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0092-8674(00)80904-6","volume":"92","author":"TE Barrett","year":"1998","unstructured":"Barrett TE, Savva R, Panayotou G, Barlow T, Brown T, Jiricny J and Pearl LH (1998) Crystal structure of a G:T\/U mismatch\u2010specific DNA glycosylase: mismatch recognition by complementary\u2010strand interactions. Cell, 92, 117\u2013129.","journal-title":"Cell"},{"key":"BFEMBJ7594926_CR5","doi-asserted-by":"crossref","first-page":"6599","DOI":"10.1093\/emboj\/18.23.6599","volume":"18","author":"TE Barrett","year":"1999","unstructured":"Barrett TE, Sch\u00e4rer OD, Savva R, Brown T, Jiricny J, Verdine GL and Pearl LH (1999) Crystal structure of a thwarted mismatch glycosylase DNA repair complex. EMBO J, 18, 6599\u20136609.","journal-title":"EMBO J"},{"key":"BFEMBJ7594926_CR6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/jmbi.2000.3857","volume":"300","author":"D Batty","year":"2000","unstructured":"Batty D, Rapic'\u2010Otrin V, Levine AS and Wood RD (2000) Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J Mol Biol, 300, 275\u2013290.","journal-title":"J Mol Biol"},{"key":"BFEMBJ7594926_CR7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/nar\/27.4.979","volume":"27","author":"T Bessho","year":"1999","unstructured":"Bessho T (1999) Nucleotide excision repair 3\u2032 endonuclease XPG stimulates the activity of base excision repair enzyme thymine glycol DNA glycosylase. Nucleic Acids Res, 27, 979\u2013983.","journal-title":"Nucleic Acids Res"},{"key":"BFEMBJ7594926_CR8","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/415655a","volume":"415","author":"KM Chou","year":"2002","unstructured":"Chou KM and Cheng YC (2002) An exonucleotic activity of human apurinic\/apyrimidinic endonuclease on 3\u2032 mispaired DNA. Nature, 415, 655\u2013659.","journal-title":"Nature"},{"key":"BFEMBJ7594926_CR9","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.275.5302.990","volume":"275","author":"PK Cooper","year":"1997","unstructured":"Cooper PK, Nouspikel T, Clarkson SG and Leadon SA (1997) Defective transcription\u2010coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science, 275, 990\u2013993.","journal-title":"Science"},{"key":"BFEMBJ7594926_CR10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1101\/gad.13.7.768","volume":"13","author":"WL de Laat","year":"1999","unstructured":"de Laat WL, Jaspers NGJ and Hoeijmakers JHJ (1999) Molecular mechanism of nucleotide excision repair. Genes Dev, 13, 768\u2013785.","journal-title":"Genes Dev"},{"key":"BFEMBJ7594926_CR11","volume-title":"DNA Repair and Mutagenesis","author":"EC Friedberg","year":"1995","unstructured":"Friedberg EC, Walker GC and Siede W (1995) DNA Repair and Mutagenesis. ASM Press, Washington, DC."},{"key":"BFEMBJ7594926_CR12","doi-asserted-by":"crossref","first-page":"20027","DOI":"10.1074\/jbc.274.28.20027","volume":"274","author":"Y Fujiwara","year":"1999","unstructured":"Fujiwara Y, Masutani C, Mizukoshi T, Kondo J, Hanaoka F and Iwai S (1999) Characterization of DNA recognition by the human UV\u2010damaged DNA\u2010binding protein. J Biol Chem, 274, 20027\u201320033.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR13","first-page":"4402","volume":"58","author":"G Giglia","year":"1998","unstructured":"Giglia G, Dumaz N, Drougard C, Avril MF, Daya\u2010Grosjean L and Sarasin A (1998) p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C. Cancer Res, 58, 4402\u20134409.","journal-title":"Cancer Res"},{"key":"BFEMBJ7594926_CR14","doi-asserted-by":"crossref","first-page":"33449","DOI":"10.1074\/jbc.M005095200","volume":"275","author":"U Hardeland","year":"2000","unstructured":"Hardeland U, Bentele M, Jiricny J and Sch\u00e4r P (2000) Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. J Biol Chem, 275, 33449\u201333456.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0079-6603(01)68103-0","volume":"68","author":"U Hardeland","year":"2001","unstructured":"Hardeland U, Bentele M, Lettieri T, Steinacher R, Jiricny J and Sch\u00e4r P (2001) Thymine DNA glycosylase. Prog Nucleic Acid Res Mol Biol, 68, 235\u2013253.","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"BFEMBJ7594926_CR16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","volume":"411","author":"JHJ Hoeijmakers","year":"2001","unstructured":"Hoeijmakers JHJ (2001) Genome maintenance mechanisms for preventing cancer. Nature, 411, 366\u2013374.","journal-title":"Nature"},{"key":"BFEMBJ7594926_CR17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1097-2765(00)80172-0","volume":"3","author":"A Klungland","year":"1999","unstructured":"Klungland A, H\u00f6ss M, Gunz D, Constantinou A, Clarkson SG, Doetsch PW, Bolton PH, Wood RD and Lindahl T (1999) Base excision repair of oxidative DNA damage activated by XPG protein. Mol Cell, 3, 33\u201342.","journal-title":"Mol Cell"},{"key":"BFEMBJ7594926_CR18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-5793(00)01674-4","volume":"476","author":"HE Krokan","year":"2000","unstructured":"Krokan HE, Nilsen H, Skorpen F, Otterlei M and Slupphaug G (2000) Base excision repair of DNA in mammalian cells. FEBS Lett, 476, 73\u201377.","journal-title":"FEBS Lett"},{"key":"BFEMBJ7594926_CR19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0921-8777(00)00082-3","volume":"485","author":"R Kusumoto","year":"2001","unstructured":"Kusumoto R, Masutani C, Sugasawa K, Iwai S, Araki M, Uchida A, Mizukoshi T and Hanaoka F (2001) Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro. Mutat Res, 485, 219\u2013227.","journal-title":"Mutat Res"},{"key":"BFEMBJ7594926_CR20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80827-2","volume":"101","author":"F Le Page","year":"2000","unstructured":"Le Page F, Kwoh EE, Avrutskaya A, Gentil A, Leadon SA, Sarasin A and Cooper PK (2000) Transcription\u2010coupled repair of 8\u2010oxoguanine: requirement for XPG, TFIIH and CSB and implications for Cockayne syndrome. Cell, 101, 159\u2013171.","journal-title":"Cell"},{"key":"BFEMBJ7594926_CR21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/jmbi.1998.1949","volume":"281","author":"RY Li","year":"1998","unstructured":"Li RY, Calsou P, Jones CJ and Salles B (1998) Interactions of the transcription\/DNA repair factor TFIIH and XP repair proteins with DNA lesions in a cell\u2010free repair assay. J Mol Biol, 281, 211\u2013218.","journal-title":"J Mol Biol"},{"key":"BFEMBJ7594926_CR22","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/j.1460-2075.1994.tb06452.x","volume":"13","author":"C Masutani","year":"1994","unstructured":"Masutani C, et al. (1994) Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J, 13, 1831\u20131843.","journal-title":"EMBO J"},{"key":"BFEMBJ7594926_CR23","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.1128\/MCB.17.12.6915","volume":"17","author":"C Masutani","year":"1997","unstructured":"Masutani C, et al. (1997) Identification and characterization of XPC\u2010binding domain of hHR23B. Mol Cell Biol, 17, 6915\u20136923.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7594926_CR24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.biochem.68.1.255","volume":"68","author":"AK McCullough","year":"1999","unstructured":"McCullough AK, Dodson ML and Lloyd RS (1999) Initiation of base excision repair: glycosylase mechanisms and structures. Annu Rev Biochem, 68, 255\u2013285.","journal-title":"Annu Rev Biochem"},{"key":"BFEMBJ7594926_CR25","doi-asserted-by":"crossref","first-page":"28433","DOI":"10.1074\/jbc.M001064200","volume":"275","author":"F Miao","year":"2000","unstructured":"Miao F, Bouziane M, Dammann R, Masutani C, Hanaoka F, Pfeifer G and O'Connor TR (2000) 3\u2010Methyladenine\u2010DNA glycosylase (MPG protein) interacts with human RAD23 proteins. J Biol Chem, 275, 28433\u201328438.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR26","doi-asserted-by":"crossref","first-page":"33569","DOI":"10.1074\/jbc.M104963200","volume":"276","author":"C Missero","year":"2001","unstructured":"Missero C, Pirro MT, Simeone S, Pischetola M and Di Lauro R (2001) The DNA glycosylase T:G mismatch\u2010specific thymine DNA glycosylase represses thyroid transcription factor\u20101\u2010activated transcription. J Biol Chem, 276, 33569\u201333575.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR27","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1074\/jbc.270.6.2415","volume":"270","author":"D Mu","year":"1995","unstructured":"Mu D, Park CH, Matsunaga T, Hsu DS, Reardon JT and Sancar A (1995) Reconstitution of human DNA repair excision nuclease in a highly defined system. J Biol Chem, 270, 2415\u20132418.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR28","doi-asserted-by":"crossref","first-page":"21218","DOI":"10.1016\/S0021-9258(19)36913-3","volume":"268","author":"P Neddermann","year":"1993","unstructured":"Neddermann P and Jiricny J (1993) The purification of a mismatch\u2010specific thymine\u2010DNA glycosylase from HeLa cells. J Biol Chem, 268, 21218\u201321224.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/carcin\/22.7.987","volume":"22","author":"H Nilsen","year":"2001","unstructured":"Nilsen H and Krokan HE (2001) Base excision repair in a network of defence and tolerance. Carcinogenesis, 22, 987\u2013998.","journal-title":"Carcinogenesis"},{"key":"BFEMBJ7594926_CR30","first-page":"1571","volume":"60","author":"AM Reis","year":"2000","unstructured":"Reis AM, Cheo DL, Meira LB, Greenblatt MS, Bond JP, Nahari D and Friedberg EC (2000) Genotype\u2010specific Trp53 mutational analysis in ultraviolet B radiation\u2010induced skin cancers in Xpc and Xpc Trp53 mutant mice. Cancer Res, 60, 1571\u20131579.","journal-title":"Cancer Res"},{"key":"BFEMBJ7594926_CR31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/1523-1747.ep12613504","volume":"104","author":"TM R\u00fcnger","year":"1995","unstructured":"R\u00fcnger TM, Epe B and M\u00f6ller K (1995) Repair of ultraviolet B and singlet oxygen\u2010induced DNA damage in xeroderma pigmentosum cells. J Invest Dermatol, 104, 68\u201373.","journal-title":"J Invest Dermatol"},{"key":"BFEMBJ7594926_CR32","doi-asserted-by":"crossref","first-page":"22749","DOI":"10.1016\/S0021-9258(17)31709-X","volume":"269","author":"MKK Shivji","year":"1994","unstructured":"Shivji MKK, Eker APM and Wood RD (1994) DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J Biol Chem, 269, 22749\u201322757.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR33","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1128\/MCB.16.9.4852","volume":"16","author":"K Sugasawa","year":"1996","unstructured":"Sugasawa K, Masutani C, Uchida A, Maekawa T, van der Spek PJ, Bootsma D, Hoeijmakers JHJ and Hanaoka F (1996) HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro. Mol Cell Biol, 16, 4852\u20134861.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7594926_CR34","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1128\/MCB.17.12.6924","volume":"17","author":"K Sugasawa","year":"1997","unstructured":"Sugasawa K, et al. (1997) Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol Cell Biol, 17, 6924\u20136931.","journal-title":"Mol Cell Biol"},{"key":"BFEMBJ7594926_CR35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1097-2765(00)80132-X","volume":"2","author":"K Sugasawa","year":"1998","unstructured":"Sugasawa K, Ng JMY, Masutani C, Iwai S, van der Spek PJ, Eker APM, Hanaoka F, Bootsma D and Hoeijmakers JHJ (1998) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell, 2, 223\u2013232.","journal-title":"Mol Cell"},{"key":"BFEMBJ7594926_CR36","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1101\/gad.866301","volume":"15","author":"K Sugasawa","year":"2001","unstructured":"Sugasawa K, Okamoto T, Shimizu Y, Masutani C, Iwai S and Hanaoka F (2001) A multistep damage recognition mechanism for global genomic nucleotide excision repair. Genes Dev, 15, 507\u2013521.","journal-title":"Genes Dev"},{"key":"BFEMBJ7594926_CR37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1568-7864(01)00008-8","volume":"1","author":"K Sugasawa","year":"2002","unstructured":"Sugasawa K, Shimizu Y, Iwai S and Hanaoka F (2002) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair, 1, 95\u2013107.","journal-title":"DNA Repair"},{"key":"BFEMBJ7594926_CR38","first-page":"641","volume":"58","author":"S Takeuchi","year":"1998","unstructured":"Takeuchi S, Nakatsu Y, Nakane H, Murai H, Hirota S, Kitamura Y, Okuyama A and Tanaka K (1998) Strand specificity and absence of hot spots for p53 mutations in ultraviolet B\u2010induced skin tumors of XPA\u2010deficient mice. Cancer Res, 58, 641\u2013646.","journal-title":"Cancer Res"},{"key":"BFEMBJ7594926_CR39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1097-2765(02)00453-7","volume":"9","author":"M Tini","year":"2002","unstructured":"Tini M, Benecke A, Um S, Torchia J, Evans RM and Chambon P (2002) Association of CBP\/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell, 9, 265\u2013277.","journal-title":"Mol Cell"},{"key":"BFEMBJ7594926_CR40","first-page":"4727","volume":"57","author":"S Tommasi","year":"1997","unstructured":"Tommasi S, Denissenko MF and Pfeifer GP (1997) Sunlight induces pyrimidine dimers preferentially at 5\u2010methylcytosine bases. Cancer Res, 57, 4727\u20134730.","journal-title":"Cancer Res"},{"key":"BFEMBJ7594926_CR41","doi-asserted-by":"crossref","first-page":"20728","DOI":"10.1074\/jbc.273.33.20728","volume":"273","author":"S Um","year":"1998","unstructured":"Um S, Harbers M, Benecke A, Pierrat B, Losson R and Chambon P (1998) Retinoic acid receptors interact physically and functionally with the T:G mismatch\u2010specific thymine\u2010DNA glycosylase. J Biol Chem, 273, 20728\u201320736.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR42","doi-asserted-by":"crossref","first-page":"20007","DOI":"10.1074\/jbc.273.32.20007","volume":"273","author":"TR Waters","year":"1998","unstructured":"Waters TR and Swann PF (1998) Kinetics of the action of thymine DNA glycosylase. J Biol Chem, 273, 20007\u201320014.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1074\/jbc.274.1.67","volume":"274","author":"TR Waters","year":"1999","unstructured":"Waters TR, Gallinari P, Jiricny J and Swann PF (1999) Human thymine DNA glycosylase binds to apurinic sites in DNA but is displaced by human apurinic endonuclease 1. J Biol Chem, 274, 67\u201374.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR47","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1038\/sj.onc.1203844","volume":"19","author":"SWP Wijnhoven","year":"2000","unstructured":"Wijnhoven SWP, Kool HJM, Mullenders LHF, van Zeeland AA, Friedberg EC, van der Horst GTJ, van Steeg H and Vrieling H (2000) Age\u2010dependent spontaneous mutagenesis in Xpc mice defective in nucleotide excision repair. Oncogene, 19, 5034\u20135037.","journal-title":"Oncogene"},{"key":"BFEMBJ7594926_CR44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0921-8777(01)00063-5","volume":"485","author":"DM Wilson III","year":"2001","unstructured":"Wilson DM,III and Barsky D (2001) The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA. Mutat Res, 485, 283\u2013307.","journal-title":"Mutat Res"},{"key":"BFEMBJ7594926_CR45","doi-asserted-by":"crossref","first-page":"9870","DOI":"10.1074\/jbc.275.13.9870","volume":"275","author":"M Yokoi","year":"2000","unstructured":"Yokoi M, Masutani C, Maekawa T, Sugasawa K, Ohkuma Y and Hanaoka F (2000) The xeroderma pigmentosum group C protein complex XPC\u2013HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA. J Biol Chem, 275, 9870\u20139875.","journal-title":"J Biol Chem"},{"key":"BFEMBJ7594926_CR46","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/emboj\/20.4.914","volume":"20","author":"J Zhou","year":"2001","unstructured":"Zhou J, Ahn J, Wilson SH and Prives C (2001) A role for p53 in base excision repair. EMBO J, 20, 914\u2013923.","journal-title":"EMBO J"}],"container-title":["The EMBO Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1093%2Femboj%2Fcdg016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/cdg016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1093\/emboj\/cdg016\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1093\/emboj\/cdg016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1093\/emboj\/cdg016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T19:13:31Z","timestamp":1779304411000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1093\/emboj\/cdg016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,2]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,2]]}},"alternative-id":["BFEMBJ7594926"],"URL":"https:\/\/doi.org\/10.1093\/emboj\/cdg016","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1011197.178314","asserted-by":"object"}]},"ISSN":["0261-4189","1460-2075"],"issn-type":[{"value":"0261-4189","type":"print"},{"value":"1460-2075","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,2]]},"assertion":[{"value":"11 July 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2002","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2002","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}