{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:07:28Z","timestamp":1740168448488,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000925","name":"John Templeton Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical University of Graz, Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The human embryo derives from fusion of oocyte and sperm, undergoes growth and differentiation, resulting in a blastocyst. To initiate implantation, the blastocyst hatches from the zona pellucida, allowing access from external inputs. Modelling of uterine sperm distribution indicates that 200\u20135000 sperm cells may reach the implantation-stage blastocyst following natural coitus. We show ultrastructural evidence of sperm cells intruding into trophectoderm cells of zona-free blastocysts obtained from the uterus of rhesus monkeys. Interaction between additional sperm and zona-free blastocyst could be an evolutionary feature yielding adaptive processes influencing the developmental fate of embryos. This process bears potential implications in pregnancy success, sperm competition and human health.<\/jats:p>","DOI":"10.1093\/emph\/eoad043","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T20:53:38Z","timestamp":1703364818000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Sperm intrusion into the implantation-stage blastocyst and its potential biological significance"],"prefix":"10.1093","volume":"12","author":[{"given":"Jayasree","family":"Sengupta","sequence":"first","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kroneis","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Histology & Embryology, Gottfried Schatz Research Center, Medical University of Graz , Graz , Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy 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