{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:06:51Z","timestamp":1774476411378,"version":"3.50.1"},"reference-count":76,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":183,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Nausea and vomiting in pregnancy (NVP) have been proposed to have a prophylactic function. In this review, I re-examine NVP from an evolutionary perspective in light of new research on NVP. First, current evidence suggests that the observed characteristics of NVP does not align well with a prophylactic function. Further, NVP is typically associated with high costs for pregnant women, while moderate-to-severe NVP is associated with increased risks of poorer foetal\/birth outcomes. In contrast, mild NVP limited to early pregnancy may associate with improved foetal outcomes\u2014indicating a potential evolutionary benefit. Second, researchers have recently identified growth differentiation factor 15 (GDF15) to cause NVP, with implications that low-levels of pre-conception GDF15 (associated with lower cellular stress\/inflammation) may increase risks\/symptoms of NVP. If so, NVP in contemporary post-industrialized populations may be more severe due to environmental mismatch, and the current symptomology of NVP in such populations should not be viewed as a typical experience of pregnancy.<\/jats:p>","DOI":"10.1093\/emph\/eoae012","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T20:48:51Z","timestamp":1719866931000},"page":"97-104","source":"Crossref","is-referenced-by-count":5,"title":["Re-examining the adaptive function of nausea and vomiting in pregnancy"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4862-179X","authenticated-orcid":false,"given":"Emily H","family":"Emmott","sequence":"first","affiliation":[{"name":"University College London UCL Anthropology, , London WC1H 0BW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"2024071609010320600_CIT0001","first-page":"e171","article-title":"Quantifying the global rates of nausea and vomiting of pregnancy: a meta analysis","volume":"20","author":"Einarson","year":"2013","journal-title":"J Popul Therap Clin Pharmacol"},{"key":"2024071609010320600_CIT0002","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1067\/mob.2002.122600","article-title":"Psychological factors in the etiology and treatment of severe nausea and vomiting in pregnancy","volume":"186","author":"Buckwalter","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"2024071609010320600_CIT0003","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41572-019-0110-3","article-title":"Nausea and vomiting of pregnancy and hyperemesis gravidarum","volume":"5","author":"Fejzo","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2024071609010320600_CIT0004","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41586-023-06921-9","article-title":"GDF15 linked to maternal risk of nausea and vomiting during pregnancy","volume":"625","author":"Fejzo","year":"2023","journal-title":"Nature"},{"key":"2024071609010320600_CIT0005","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00424-020-02459-1","article-title":"GDF15, an update of the physiological and pathological roles it plays: a review","volume":"472","author":"Assadi","year":"2020","journal-title":"Pflugers Archiv"},{"key":"2024071609010320600_CIT0006","doi-asserted-by":"crossref","first-page":"S190","DOI":"10.1067\/mob.2002.122593","article-title":"Nausea and vomiting of pregnancy in an evolutionary perspective","volume":"186","author":"Sherman","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"2024071609010320600_CIT0007","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1471-0528.2008.01891.x","article-title":"Nausea and vomiting of pregnancy: What about quality of life","volume":"115","author":"Lacasse","year":"2008","journal-title":"BJOG"},{"key":"2024071609010320600_CIT0008","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/ajo.12714","article-title":"Nausea and vomiting of pregnancy: effects on quality of life and day-to-day function","volume":"58","author":"Tan","year":"2018","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2024071609010320600_CIT0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/01674820701733697","article-title":"Nausea and vomiting in early pregnancy: relationship with anxiety and depression","volume":"29","author":"K\u00f6ken","year":"2008","journal-title":"J Psychosom Obstet Gynaecol"},{"key":"2024071609010320600_CIT0010","doi-asserted-by":"crossref","first-page":"e039715","DOI":"10.1136\/bmjopen-2020-039715","article-title":"Association between hyperemesis gravidarum and psychological symptoms, psychosocial outcomes and infant bonding: a two-point prospective case\u2013control multicentre survey study in an inner city setting","volume":"10","author":"Mitchell-Jones","year":"2020","journal-title":"BMJ Open"},{"key":"2024071609010320600_CIT0011","doi-asserted-by":"crossref","first-page":"12861","DOI":"10.3390\/ijerph191912861","article-title":"Transition to motherhood: a study on the association between somatic symptoms during pregnancy and post-partum anxiety and depression symptoms","volume":"19","author":"Tambelli","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"2024071609010320600_CIT0012","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jpag.2015.06.010","article-title":"Nausea and vomiting in early pregnancy of adolescents: relationship with depressive symptoms","volume":"29","author":"Yilmaz","year":"2016","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"2024071609010320600_CIT0013","first-page":"e149","article-title":"Economic burden of nausea and vomiting of pregnancy in the USA","volume":"20","author":"Piwko","year":"2013","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"2024071609010320600_CIT0014","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1086\/324128","article-title":"Reproductive immunosuppression and diet: an evolutionary perspective on pregnancy sickness and meat consumption","volume":"43","author":"Fessler","year":"2002","journal-title":"Curr Anthropol"},{"key":"2024071609010320600_CIT0015","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.evolhumbehav.2004.12.001","article-title":"Elevated disgust sensitivity in the first trimester of pregnancy: evidence supporting the compensatory prophylaxis hypothesis","volume":"26","author":"Fessler","year":"2005","journal-title":"Evol Hum Behav"},{"key":"2024071609010320600_CIT0016","first-page":"779","article-title":"Nausea and vomiting in early pregnancy: its role in placental development","volume":"95","author":"Huxley","year":"2000","journal-title":"Obstet Gynecol"},{"key":"2024071609010320600_CIT0017","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/oso\/9780195060232.003.0009","article-title":"Pregnancy sickness as adaptation: a deterrent to maternal ingestion of teratogens","volume-title":"The Adapted Mind: Evolutionary Psychology and the Generation of Culture","author":"Profet","year":"1992"},{"key":"2024071609010320600_CIT0018","first-page":"177","article-title":"The evolution of pregnancy sickness as protection to the embryo against Pleistocene teratogens","volume":"8","author":"Profet","year":"1988","journal-title":"Evol Theory"},{"key":"2024071609010320600_CIT0019","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1086\/393377","article-title":"Morning sickness: a mechanism for protecting mother and embryo","volume":"75","author":"Flaxman","year":"2000","journal-title":"Q Rev Biol"},{"key":"2024071609010320600_CIT0020","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-59745-112-3","volume-title":"Handbook of Nutrition and Pregnancy","author":"Lammi-Keefe","year":"2008"},{"key":"2024071609010320600_CIT0021","first-page":"2675","article-title":"Rates of nausea and vomiting in pregnancy and dietary characteristics across populations","volume":"273","author":"Pepper","year":"2006","journal-title":"Proc Biol Sci"},{"key":"2024071609010320600_CIT0022","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1001\/jamainternmed.2016.5641","article-title":"Association of nausea and vomiting during pregnancy with pregnancy loss: a secondary analysis of a randomized clinical trial","volume":"176","author":"Hinkle","year":"2016","journal-title":"JAMA Intern Med"},{"key":"2024071609010320600_CIT0023","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2014.05.012","article-title":"The protective effects of nausea and vomiting of pregnancy against adverse fetal outcome\u2014a systematic review","volume":"47","author":"Koren","year":"2014","journal-title":"Reprod Toxicol"},{"key":"2024071609010320600_CIT0024","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12884-018-1911-1","article-title":"Nausea and vomiting during pregnancy associated with lower incidence of preterm births: the Japan Environment and Children\u2019s Study (JECS)","volume":"18","author":"Mitsuda","year":"2018","journal-title":"BMC Pregnancy Childbirth"},{"key":"2024071609010320600_CIT0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12884-015-0580-6","article-title":"Pregnancy complications and birth outcomes among women experiencing nausea only or nausea and vomiting during pregnancy in the Norwegian Mother and Child Cohort Study","volume":"15","author":"Chortatos","year":"2015","journal-title":"BMC Preg Childbirth"},{"key":"2024071609010320600_CIT0026","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/1471-0528.12406","article-title":"Nausea and vomiting in pregnancy: associations with maternal gestational diet and lifestyle factors in the Norwegian Mother and Child Cohort Study","volume":"120","author":"Chortatos","year":"2013","journal-title":"BJOG"},{"key":"2024071609010320600_CIT0027","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-277X.2009.01019.x","article-title":"Dietary and clinical impacts of nausea and vomiting during pregnancy","volume":"23","author":"Latva-Pukkila","year":"2010","journal-title":"J Hum Nutr Diet"},{"key":"2024071609010320600_CIT0028","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3390\/nu15040933","article-title":"Nausea and vomiting during early pregnancy among Chinese women and its association with nutritional intakes","volume":"15","author":"Zhu","year":"2023","journal-title":"Nutrients"},{"key":"2024071609010320600_CIT0029","doi-asserted-by":"crossref","first-page":"e12389","DOI":"10.1111\/mcn.12389","article-title":"Nausea and vomiting in early pregnancy: Effects on food intake and diet quality","volume":"13","author":"Crozier","year":"2017","journal-title":"Matern Child Nutr"},{"key":"2024071609010320600_CIT0030","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-3016.2012.01281.x","article-title":"Effect of women\u2019s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review","volume":"26","author":"Ramakrishnan","year":"2012","journal-title":"Paediatr Perinat Epidemiol"},{"key":"2024071609010320600_CIT0031","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.3390\/nu12061799","article-title":"Associations between first trimester maternal nutritional score, early markers of placental function, and pregnancy outcome","volume":"12","author":"Parisi","year":"2020","journal-title":"Nutrients"},{"key":"2024071609010320600_CIT0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/197140091302600106","article-title":"Wernicke\u2019s encephalopathy following hyperemesis gravidarum: a report of three cases","volume":"26","author":"Kotha","year":"2013","journal-title":"Neuroradiol J"},{"key":"2024071609010320600_CIT0033","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/humupd\/dmv041","article-title":"The role of infection in miscarriage","volume":"22","author":"Giakoumelou","year":"2016","journal-title":"Hum Reprod Update"},{"key":"2024071609010320600_CIT0034","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/B978-0-12-384947-2.00491-8","article-title":"Nutrition and infection","volume-title":"Encyclopedia of Food and Health","author":"Rodriguez-Morales","year":"2016"},{"key":"2024071609010320600_CIT0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/09513590.2013.852531","article-title":"The immune system and aging: a review","volume":"30","author":"Castelo-Branco","year":"2014","journal-title":"Gynecol Endocrinol"},{"key":"2024071609010320600_CIT0036","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1053\/beog.2000.0123","article-title":"Epidemiology and the medical causes of miscarriage","volume":"14","author":"Regan","year":"2000","journal-title":"Bailliere's Best Pract Res Clin Obstetr Gynaecol"},{"key":"2024071609010320600_CIT0037","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3109\/00016347909154905","article-title":"Maternal alcohol and tobacco consumption and their association with nausea and vomiting during pregnancy","volume":"58","author":"Little","year":"1979","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2024071609010320600_CIT0038","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/oxfordjournals.aje.a114831","article-title":"The association of reproductive history, demographic factors, and alcohol and tobacco consumption with the risk of developing nausea and vomiting in early pregnancy","volume":"127","author":"Weigel","year":"1988","journal-title":"Am J Epidemiol"},{"key":"2024071609010320600_CIT0039","doi-asserted-by":"crossref","first-page":"J258","DOI":"10.1016\/j.jaut.2009.12.003","article-title":"Effects of tobacco smoke on immunity, inflammation and autoimmunity","volume":"34","author":"Arnson","year":"2010","journal-title":"J Autoimmun"},{"key":"2024071609010320600_CIT0040","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/aje\/kwt334","article-title":"Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy","volume":"179","author":"Pineles","year":"2014","journal-title":"Am J Epidemiol"},{"key":"2024071609010320600_CIT0041","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1440-1843.2003.00483.x","article-title":"History of tobacco and health","volume":"8","author":"Musk","year":"2003","journal-title":"Respirology"},{"key":"2024071609010320600_CIT0042","first-page":"245","article-title":"A prospective study of nausea and vomiting during pregnancy","volume":"43","author":"Gadsby","year":"1993","journal-title":"Br J Gen Pract"},{"key":"2024071609010320600_CIT0043","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1479-828X.2000.tb01167.x","article-title":"The impact of nausea and vomiting on women: a burden of early pregnancy","volume":"40","author":"Smith","year":"2000","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2024071609010320600_CIT0044","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/pch\/9.8.575","article-title":"Maternal depression and child development","volume":"9","author":"Bernard-Bonnin","year":"2004","journal-title":"Paediatr Child Health"},{"key":"2024071609010320600_CIT0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1753495X19843015","article-title":"Antenatal depression and offspring health outcomes","volume":"13","author":"Smith","year":"2020","journal-title":"Obstet Med"},{"key":"2024071609010320600_CIT0046","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00787-014-0582-3","article-title":"Antenatal depression and children\u2019s developmental outcomes: potential mechanisms and treatment options","volume":"23","author":"Waters","year":"2014","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"2024071609010320600_CIT0047","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1365-3016.2004.00568.x","article-title":"Association between severe nausea and vomiting in pregnancy and lower rate of preterm births","volume":"18","author":"Czeizel","year":"2004","journal-title":"Paediatr Perinat Epidemiol"},{"key":"2024071609010320600_CIT0048","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41467-018-03258-0","article-title":"Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum","volume":"9","author":"Fejzo","year":"2018","journal-title":"Nat Commun"},{"key":"2024071609010320600_CIT0049","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3109\/01443615.2013.767788","article-title":"Pregnancy outcomes in severe hyperemesis gravidarum in a multi-ethnic population","volume":"33","author":"Vlachodimitropoulou-Koumoutsea","year":"2013","journal-title":"J Obstet Gynaecol"},{"key":"2024071609010320600_CIT0050","doi-asserted-by":"crossref","first-page":"102472","DOI":"10.1016\/j.canep.2023.102472","article-title":"Hyperemesis gravidarum and the risk of childhood cancer\u2014a case-control study in Denmark","volume":"87","author":"Orimoloye","year":"2023","journal-title":"Cancer Epidemiol"},{"key":"2024071609010320600_CIT0051","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0039-1696670","article-title":"Autism spectrum disorders in children exposed in utero to hyperemesis gravidarum","volume":"38","author":"Getahun","year":"2021","journal-title":"Am J Perinatol"},{"key":"2024071609010320600_CIT0052","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/ppul.26817","article-title":"The impact of maternal hyperemesis gravidarum on early childhood respiratory morbidity","volume":"59","author":"Hazan","year":"2024","journal-title":"Pediatr Pulmonol"},{"key":"2024071609010320600_CIT0053","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12884-024-06293-6","article-title":"Offspring of women with hyperemesis gravidarum are more likely to have cardiovascular abnormalities","volume":"24","author":"Fan","year":"2024","journal-title":"BMC Preg Childbirth"},{"key":"2024071609010320600_CIT0054","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12916-020-01701-y","article-title":"Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children","volume":"18","author":"Wang","year":"2020","journal-title":"BMC Med"},{"key":"2024071609010320600_CIT0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12884-018-1786-1","article-title":"Vomiting in pregnancy is associated with a higher risk of low birth weight: a cohort study","volume":"18","author":"Petry","year":"2018","journal-title":"BMC Preg Childbirth"},{"key":"2024071609010320600_CIT0056","doi-asserted-by":"crossref","first-page":"e017309","DOI":"10.1136\/bmjopen-2017-017309","article-title":"Association between vomiting in the first trimester and preterm birth: a retrospective birth cohort study in Wuhan, China","volume":"7","author":"Hu","year":"2017","journal-title":"BMJ Open"},{"key":"2024071609010320600_CIT0057","doi-asserted-by":"crossref","first-page":"e2334","DOI":"10.1002\/bdr2.2334","article-title":"The timing, duration, and severity of nausea and vomiting of pregnancy and adverse birth outcomes among controls without birth defects in the National Birth Defects Prevention Study","volume":"116","author":"Schrager","year":"2024","journal-title":"Birth Defects Res"},{"key":"2024071609010320600_CIT0058","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/1471-0528.12132","article-title":"Hyperemesis gravidarum and risks of placental dysfunction disorders: a population-based cohort study","volume":"120","author":"Bolin","year":"2013","journal-title":"BJOG"},{"key":"2024071609010320600_CIT0059","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0143-4004(98)90105-9","article-title":"Compensatory placental growth after restricted maternal nutrition in early pregnancy","volume":"19","author":"Lunney","year":"1998","journal-title":"Placenta"},{"key":"2024071609010320600_CIT0060","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1113\/EP090442","article-title":"Placental adaptations supporting fetal growth during normal and adverse gestational environments","volume":"108","author":"Sferruzzi-Perri","year":"2023","journal-title":"Exp Physiol"},{"key":"2024071609010320600_CIT0061","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/AOG.0b013e318253d3df","article-title":"Placental weight for gestational age and adverse perinatal outcomes","volume":"119","author":"Hutcheon","year":"2012","journal-title":"Obstet Gynecol"},{"key":"2024071609010320600_CIT0062","doi-asserted-by":"crossref","first-page":"809270","DOI":"10.3389\/fmed.2021.809270","article-title":"Emerging progress in nausea and vomiting of pregnancy and hyperemesis gravidarum: challenges and opportunities","volume":"8","author":"Liu","year":"2022","journal-title":"Front Med"},{"key":"2024071609010320600_CIT0063","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/humupd\/dmi021","article-title":"Hyperemesis gravidarum, a literature review","volume":"11","author":"Verberg","year":"2005","journal-title":"Hum Reprod Update"},{"key":"2024071609010320600_CIT0064","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejogrb.2017.12.015","article-title":"Maternal human chorionic gonadotrophin concentrations in very early pregnancy and risk of hyperemesis gravidarum: a retrospective cohort study of 4372 pregnancies after in vitro fertilization","volume":"221","author":"Dypvik","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2024071609010320600_CIT0065","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molmet.2017.12.016","article-title":"Exercise increases circulating GDF15 in humans","volume":"9","author":"Kleinert","year":"2018","journal-title":"Mol Metab"},{"key":"2024071609010320600_CIT0066","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12020-023-03377-9","article-title":"Growth differentiation factor 15 (GDF-15) in endocrinology","volume":"81","author":"Iglesias","year":"2023","journal-title":"Endocrine"},{"key":"2024071609010320600_CIT0067","doi-asserted-by":"crossref","first-page":"e13514","DOI":"10.1111\/cpr.13514","article-title":"Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion","volume":"56","author":"Lyu","year":"2023","journal-title":"Cell Prolif"},{"key":"2024071609010320600_CIT0068","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-019-1911-y","article-title":"GDF15 mediates the effects of metformin on body weight and energy balance","volume":"578","author":"Coll","year":"2020","journal-title":"Nature"},{"key":"2024071609010320600_CIT0069","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/1471-0528.17129","article-title":"Whole-exome sequencing uncovers new variants in GDF15 associated with hyperemesis gravidarum","volume":"129","author":"Fejzo","year":"2022","journal-title":"BJOG"},{"key":"2024071609010320600_CIT0070","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cmet.2018.12.016","article-title":"GDF15 Provides an endocrine signal of nutritional stress in mice and humans","volume":"29","author":"Patel","year":"2019","journal-title":"Cell Metab"},{"key":"2024071609010320600_CIT0071","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12016-011-8285-8","article-title":"Hygiene hypothesis and autoimmune diseases","volume":"42","author":"Rook","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"2024071609010320600_CIT0072","doi-asserted-by":"crossref","first-page":"e22919","DOI":"10.1002\/ajhb.22919","article-title":"Physical activity patterns and biomarkers of cardiovascular disease risk in hunter-gatherers","volume":"29","author":"Raichlen","year":"2017","journal-title":"Am J Hum Biol"},{"key":"2024071609010320600_CIT0073","doi-asserted-by":"crossref","first-page":"e23205","DOI":"10.1002\/ajhb.23205","article-title":"High levels of objectively measured physical activity across adolescence and adulthood among the Pokot pastoralists of Kenya","volume":"31","author":"Sayre","year":"2019","journal-title":"Am J Hum Biol"},{"key":"2024071609010320600_CIT0074","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ajpa.24075","article-title":"Sex differences in daily activity intensity and energy expenditure and their relationship to cortisol among","volume":"172","author":"Sarma","year":"2020","journal-title":"Am J Phys Anthropol"},{"key":"2024071609010320600_CIT0075","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/03630242.2023.2219749","article-title":"The far-reaching burden of Hyperemesis Gravidarum\u2014an exploration of women\u2019s experiences and perceptions of healthcare support","volume":"63","author":"Beirne","year":"2023","journal-title":"Women Health"},{"key":"2024071609010320600_CIT0076","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/1742-6723.13909","article-title":"Review article: management of hyperemesis gravidarum and nausea and vomiting in pregnancy","volume":"34","author":"Lowe","year":"2022","journal-title":"Emerg Med Australas"}],"container-title":["Evolution, Medicine, and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/emph\/advance-article-pdf\/doi\/10.1093\/emph\/eoae012\/58390417\/eoae012.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/emph\/article-pdf\/12\/1\/97\/58552894\/eoae012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/emph\/article-pdf\/12\/1\/97\/58552894\/eoae012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T09:02:01Z","timestamp":1721120521000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/emph\/article\/12\/1\/97\/7702671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/emph\/eoae012","relation":{},"ISSN":["2050-6201"],"issn-type":[{"value":"2050-6201","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024,1,1]]}}}