{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:13:36Z","timestamp":1778523216384,"version":"3.51.4"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Stollery Children\u2019s Hospital Foundation as a Distinguished Researcher with the Stollery Science Lab"},{"name":"Canada Research Chair in Knowledge Synthesis and Translation"},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The large number of people infected by SARS-CoV-2 necessitates estimation of the future health care burdens. We updated a systematic review examining associations between SARS-CoV-2 infection and incidence of new diagnoses and exacerbations of chronic conditions. Updated searches were run September 4, 2024, in the MEDLINE and Embase databases for observational studies with a control group, adjustment by sex and comorbid conditions, and reporting age-stratified data for 1 or more chronic condition category (n\u00a0=\u00a012) or condition type (n\u00a0=\u00a046) of interest. Two human reviewers screened 50% of titles and abstracts, then DistillerAI acted as second reviewer. Two human reviewers assessed full texts of relevant studies for eligibility based on a priori criteria. One reviewer extracted data and assessed risk of bias using the JBI cohort studies checklist; a second reviewer verified results data and risk-of-bias assessments. Pooled hazard ratios (HRs) were estimated with inverse-variance weighting. Using the Grading of Recommendations, Assessment, Development, and Evaluation approach, 2 reviewers assessed certainty in conclusions of little to no association (ie, HR = 0.75-1.25), small to moderate association (ie, HR = 0.51-0.74 or 1.26-1.99), or large association (ie, HR \u2264\u20090.50 or\u00a0\u2265\u00a02.00). We identified 46 new studies and brought forward 23 studies from the original review. After SARS-CoV-2 infection, there is probably increased risk of new diagnoses for several chronic conditions, especially in adults. Most findings are based on data from earlier pandemic periods; their relevance to contemporary populations is uncertain due to differences in vaccination rates and circulating variants of concern.<\/jats:p>\n                  <jats:p>PROSPERO registration identifier CRD42024585278.<\/jats:p>","DOI":"10.1093\/epirev\/mxaf018","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:38:08Z","timestamp":1763645888000},"source":"Crossref","is-referenced-by-count":0,"title":["Risk of new diagnoses and exacerbations of chronic conditions after SARS-CoV-2 infection: a systematic review update"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-1749","authenticated-orcid":false,"given":"Lindsay A","family":"Gaudet","sequence":"first","affiliation":[{"name":"Alberta Research Center for Health Evidence, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-7229","authenticated-orcid":false,"given":"Jennifer","family":"Pillay","sequence":"additional","affiliation":[{"name":"Alberta Research Center for Health Evidence, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-1248","authenticated-orcid":false,"given":"Dianne","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Lifespan Chronic Diseases and Conditions Division, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada , Ottawa, ON ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-6998","authenticated-orcid":false,"given":"Sabrina","family":"Saba","sequence":"additional","affiliation":[{"name":"Alberta Research Center for Health Evidence, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-5251","authenticated-orcid":false,"given":"Ben","family":"Vandermeer","sequence":"additional","affiliation":[{"name":"Epidemiology Coordinating and Research Centre, Faculty of Medicine & Dentistry, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-3974","authenticated-orcid":false,"given":"Maria","family":"Tan","sequence":"additional","affiliation":[{"name":"Alberta Research Center for Health Evidence, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8341-3991","authenticated-orcid":false,"given":"Lisa","family":"Hartling","sequence":"additional","affiliation":[{"name":"Alberta Research Center for Health Evidence, University of Alberta , Edmonton, AB ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"issue":"5","key":"2026051113452999700_ref1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/10408363.2020.1860895","article-title":"COVID-19: from an acute to chronic disease? 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