{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:16:17Z","timestamp":1787224577230,"version":"build-2736575974"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203988"],"award-info":[{"award-number":["82203988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gastrointestinal (GI) diseases represent a significant global health burden, and emerging evidence suggests air pollution may be a risk factor. We reviewed relevant literature and performed a meta-analysis. We searched original studies investigated the associations between long- and short-term exposure to particulate matter (diameter\u00a0\u2264\u00a02.5 \u00b5m [PM2.5], \u2264\u200910 \u00b5m [PM10]) and gaseous pollutants (nitrogen dioxide, sulfur dioxide, carbon monoxide, and ozone [O3]) and GI diseases. DerSimonian and Laird random-effects meta-analyses were conducted when at least 2 studies were available for a given pollutant (per 10 \u03bcg m\u22123 increment) and a specific GI disease. A total of 70 studies were included. Long-term exposure to PM2.5 was significantly associated with increased mortality rate from all GI cancers (OR\u00a0=\u00a01.128; 95% CI, 1.019-1.248), with the strongest association observed for colorectal cancer (OR\u00a0=\u00a01.214; 95% CI, 1.061-1.389). For non-cancer GI diseases, long-term exposure to PM2.5 was significantly associated with increased risks of duodenal ulcer (OR\u00a0=\u00a01.073; 95% CI, 1.057-1.089) and irritable bowel syndrome (OR\u00a0=\u00a01.353; 95% CI, 1.222-1.497); PM10 was also linked to the latter (OR\u00a0=\u00a01.108; 95% CI, 1.012-1.213). Short-term exposure, particularly to PM2.5, PM10, and O3, was significantly associated with appendicitis hospitalization (OR\u00a0=\u00a01.003 [95% CI, 1.001-1.004]; OR\u00a0=\u00a01.017 [95% CI, 1.015-1.019]; and OR\u00a0=\u00a01.001 [95% CI, 1.000-1.003], respectively). PM2.5 was also associated with peptic ulcer bleeding (OR\u00a0=\u00a01.006; 95% CI, 1.001-1.011). Long- and short-term exposures to air pollution, especially PM2.5, are associated with increased risks of GI diseases.<\/jats:p>","DOI":"10.1093\/epirev\/mxag005","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:41:24Z","timestamp":1776253284000},"source":"Crossref","is-referenced-by-count":2,"title":["Exposure to air pollution and risk of gastrointestinal diseases: a systematic review and meta-analysis of epidemiological evidence"],"prefix":"10.1093","volume":"48","author":[{"given":"Meiqi","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou 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,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Pediatric General Surgery, Guangdong Women and Children Hospital , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-1650","authenticated-orcid":false,"given":"Yin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-9408","authenticated-orcid":false,"given":"Hualiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, Sun Yat-sen University , Guangzhou 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