{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:01:22Z","timestamp":1781625682667,"version":"3.54.5"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>HPV-induced oropharyngeal cancer (HPV-OPC), caused by persistent infection with high-risk subtypes such as HPV16 and HPV18, poses a significant global health challenge. Epidemiological research on HPV-OPC focuses on prevention, detection, distribution, and disease incidence, revealing an increasing OPC burden related to HPV exposure. The objective of this study was to identify research hotspots and trends in HPV-OPC epidemiology, highlighting the role of epidemiology in guiding prevention and control strategies. A bibliometric analysis of 960 articles (published between 1987 and 2025) from the Web of Science Core Collection, SCOPUS, and PubMed Central was performed, using Python to assess collaborations across countries, institutions, and individuals, as well as literature citation, research timelines, and clustering. Results show a substantial increase in publications, especially from 2013 to 2025, with researchers in United States and China as leading contributors and identifies several prolific authors. Research has primarily focused on HPV vaccination, screening, attributable fraction, and incidence prediction, though challenges such as data quality, vaccination efficacy, limited resource, and modeling limitations also are foci. Future directions include improving data reliability, promoting early and direct vaccination, strengthening international funding, and integrating multiple models. This bibliometric study provides valuable insights into research hotspots and future directions in HPV-OPC, offering researchers and clinicians an overview of current situations and future developments in HPV-OPC epidemiology, potentially improving HPV vaccination and screening strategies and promoting preventive and diagnostic approaches to reduce OPC incidence.<\/jats:p>","DOI":"10.1093\/epirev\/mxag006","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:15:54Z","timestamp":1773404154000},"source":"Crossref","is-referenced-by-count":1,"title":["Current trends and future prospects of epidemiology of HPV-induced oropharyngeal cancer: a bibliometric analysis"],"prefix":"10.1093","volume":"48","author":[{"given":"Wenjing","family":"Guo","sequence":"first","affiliation":[{"name":"School of Stomatology, Southwest Medical University , Luzhou, Sichuan 646000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Southwest Medical University , Luzhou, Sichuan 646000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzhi","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Architectural Engineering, Beijing University of Technology , Beijing 100124 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"issue":"3","key":"2026051113453103500_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2537","article-title":"Human papillomavirus infection: epidemiology, biology, host interactions, cancer development, prevention, and therapeutics","volume":"34","author":"Wolf","year":"2024","journal-title":"Rev Med Virol"},{"issue":"4","key":"2026051113453103500_ref2","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1002\/ijc.30716","article-title":"Worldwide burden of cancer attributable to HPV by site, country and HPV type","volume":"141","author":"De Martel","year":"2017","journal-title":"Int J Cancer"},{"key":"2026051113453103500_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104736","article-title":"Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI","volume":"108","author":"Kreimer","year":"2020","journal-title":"Oral Oncol"},{"issue":"32","key":"2026051113453103500_ref4","doi-asserted-by":"publisher","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"Chaturvedi","year":"2011","journal-title":"J Clin Oncol"},{"issue":"16","key":"2026051113453103500_ref5","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.3390\/cancers15164080","article-title":"Human papillomavirus-associated oropharyngeal cancer: global epidemiology and public policy implications","volume":"15","author":"Ndon","year":"2023","journal-title":"Cancers."},{"issue":"5","key":"2026051113453103500_ref6","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41571-022-00603-7","article-title":"HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management","volume":"19","author":"Lechner","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"2026051113453103500_ref7","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1200\/JCO.2017.75.0141","article-title":"Effect of prophylactic human papillomavirus (HPV) vaccination on oral HPV infections among young adults in the United States","volume":"36","author":"Chaturvedi","year":"2018","journal-title":"J Clin Oncol"},{"key":"2026051113453103500_ref8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.15585\/mmwr.mm6526a1","article-title":"Human papillomavirus\u2013associated cancers\u2014United States, 2008\u20132012","author":"Viens","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"18","key":"2026051113453103500_ref9","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1200\/JCO.19.00370","article-title":"Evolution of the oropharynx cancer epidemic in the United States: moderation of increasing incidence in younger individuals and shift in the burden to older individuals","volume":"37","author":"Tota","year":"2019","journal-title":"J Clin Oncol"},{"issue":"7\u20138","key":"2026051113453103500_ref10","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1080\/21645515.2019.1600985","article-title":"HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection","volume":"15","author":"Timbang","year":"2019","journal-title":"Hum Vaccin Immunother"},{"issue":"8","key":"2026051113453103500_ref11","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/S1470-2045(10)70017-6","article-title":"HPV-associated head and neck cancer: a virus-related cancer epidemic","volume":"11","author":"Marur","year":"2010","journal-title":"Lancet Oncol"},{"key":"2026051113453103500_ref12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","article-title":"How to conduct a bibliometric analysis: an overview and guidelines","volume":"133","author":"Donthu","year":"2021","journal-title":"J Bus Res"},{"issue":"4","key":"2026051113453103500_ref13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.12720\/jait.12.4.287-295","article-title":"Saturated betweenness centrality sets of vertices in graphs","volume":"12","author":"Maier","year":"2021","journal-title":"J Adv Inf Technol"},{"issue":"3","key":"2026051113453103500_ref14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.joi.2009.03.004","article-title":"Towards an explanatory and computational theory of scientific discovery","volume":"3","author":"Chen","year":"2009","journal-title":"J Informet"},{"issue":"5","key":"2026051113453103500_ref15","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1145\/324133.324140","article-title":"Authoritative sources in a hyperlinked environment","volume":"46","author":"Kleinberg","year":"1999","journal-title":"J ACM"},{"issue":"1","key":"2026051113453103500_ref16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12874-022-01673-y","article-title":"Meta-analysis using Python: a hands-on tutorial","volume":"22","author":"Masoumi","year":"2022","journal-title":"BMC Med Res Methodol"},{"issue":"S1","key":"2026051113453103500_ref17","doi-asserted-by":"publisher","first-page":"E132","DOI":"10.1002\/mc.21882","article-title":"Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck","volume":"51","author":"Lu","year":"2012","journal-title":"Mol Carcinog"},{"issue":"14","key":"2026051113453103500_ref18","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1002\/cncr.28107","article-title":"Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers","volume":"119","author":"Gan","year":"2013","journal-title":"Cancer"},{"issue":"9","key":"2026051113453103500_ref19","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.oraloncology.2015.06.005","article-title":"Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior","volume":"51","author":"Dahlstrom","year":"2015","journal-title":"Oral Oncol"},{"issue":"1","key":"2026051113453103500_ref20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1365-2214.2010.01145_7.x","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"issue":"19","key":"2026051113453103500_ref21","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1056\/NEJMoa065497","article-title":"Case\u2013control study of human papillomavirus and oropharyngeal cancer","volume":"356","author":"D'Souza","year":"2007","journal-title":"N Engl J Med"},{"issue":"4","key":"2026051113453103500_ref22","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1200\/JCO.2007.14.1713","article-title":"Incidence trends for human papillomavirus\u2013related and\u2013unrelated oral squamous cell carcinomas in the United States","volume":"26","author":"Chaturvedi","year":"2008","journal-title":"J Clin Oncol"},{"issue":"36","key":"2026051113453103500_ref23","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1200\/JCO.2013.50.3870","article-title":"Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers","volume":"31","author":"Chaturvedi","year":"2013","journal-title":"J Clin Oncol"},{"issue":"29","key":"2026051113453103500_ref24","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1200\/JCO.2015.61.6995","article-title":"Epidemiology of human papillomavirus\u2013positive head and neck squamous cell carcinoma","volume":"33","author":"Gillison","year":"2015","journal-title":"J Clin Oncol"},{"issue":"4","key":"2026051113453103500_ref25","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus\u2013positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"2026051113453103500_ref26","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/jnci\/92.9.709","article-title":"Evidence for a causal association between human papillomavirus and a subset of head and neck cancers","volume":"92","author":"Gillison","year":"2000","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"2026051113453103500_ref27","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1158\/1055-9965.EPI-04-0551","article-title":"Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review","volume":"14","author":"Kreimer","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2026051113453103500_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvr.2022.200245","article-title":"HPV and head and neck cancers: towards early diagnosis and prevention","volume":"14","author":"Galati","year":"2022","journal-title":"Tumour Virus Res"},{"key":"2026051113453103500_ref29","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/bmj.h2016","article-title":"Direct benefit of vaccinating boys along with girls against oncogenic human papillomavirus: Bayesian evidence synthesis","author":"Bogaards","year":"2015","journal-title":"BMJ"},{"issue":"4","key":"2026051113453103500_ref30","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/OLQ.0000000000001923","article-title":"Sexual behavior and perceived risk for oropharyngeal cancer among men who have sex with men: a psychometric scale validation","volume":"51","author":"Bennis","year":"2024","journal-title":"Sex Transm Dis"},{"issue":"2","key":"2026051113453103500_ref31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000494710","article-title":"HPV infections in heterosexual couples: mechanisms and covariates of virus transmission","volume":"63","author":"Kero","year":"2019","journal-title":"Acta Cytol"},{"issue":"4","key":"2026051113453103500_ref32","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/cam4.424","article-title":"Current trends in the etiology and diagnosis of HPV-related head and neck cancers","volume":"4","author":"Chai","year":"2015","journal-title":"Cancer Med"},{"key":"2026051113453103500_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104475","article-title":"Two for the price of one: prevalence, demographics and treatment implications of multiple HPV mediated head and neck cancers","volume":"100","author":"Strober","year":"2020","journal-title":"Oral Oncol"},{"issue":"16","key":"2026051113453103500_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70133","article-title":"Trends in HPV-associated cancer incidence in Texas medically underserved regions","volume":"13","author":"Hoang","year":"2024","journal-title":"Cancer Med"},{"issue":"9","key":"2026051113453103500_ref35","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1002\/hed.26284","article-title":"Sociodemographic correlates of head and neck cancer survival among patients with metastatic disease","volume":"42","author":"Pannu","year":"2020","journal-title":"Head Neck"},{"issue":"S1","key":"2026051113453103500_ref36","doi-asserted-by":"publisher","first-page":"E54","DOI":"10.1002\/mc.21838","article-title":"Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck","volume":"51","author":"Zhou","year":"2012","journal-title":"Mol Carcinog"},{"issue":"4","key":"2026051113453103500_ref37","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/ijc.34023","article-title":"Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck","volume":"151","author":"Liu","year":"2022","journal-title":"Int J Cancer"},{"issue":"9","key":"2026051113453103500_ref38","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/cncr.34124","article-title":"Prevalence of human papillomavirus in head and neck cancers at tertiary care centers in the United States over time","volume":"128","author":"Scott-Wittenborn","year":"2022","journal-title":"Cancer"},{"issue":"4","key":"2026051113453103500_ref39","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/CEJ.0000000000000179","article-title":"Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium","volume":"25","author":"Boffetta","year":"2016","journal-title":"Eur J Cancer Prev"},{"issue":"9","key":"2026051113453103500_ref40","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1002\/lary.27153","article-title":"Short-and long-term outcomes of oropharyngeal cancer care in the elderly","volume":"128","author":"Motz","year":"2018","journal-title":"Laryngoscope"},{"issue":"10","key":"2026051113453103500_ref41","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1002\/cncr.31322","article-title":"Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals","volume":"124","author":"Fakhry","year":"2018","journal-title":"Cancer"},{"key":"2026051113453103500_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2025.107249","article-title":"Oral HPV incidence and risk factors for acquisition","volume":"163","author":"Dsouza","year":"2025","journal-title":"Oral Oncol"},{"issue":"3","key":"2026051113453103500_ref43","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1093\/infdis\/jiae004","article-title":"Association of oral microbiome with oral human papillomavirus infection: a population study of the national health and nutrition examination survey, 2009\u20132012","volume":"230","author":"Feng","year":"2024","journal-title":"J Infect Dis"},{"issue":"3","key":"2026051113453103500_ref44","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/jso.2930520316","article-title":"Oral cancer and human papillomaviruses: is there a link?","volume":"52","author":"Lakshmi","year":"1993","journal-title":"J Surg Oncol"},{"issue":"2","key":"2026051113453103500_ref45","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.canlet.2012.11.048","article-title":"Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx","volume":"330","author":"Guan","year":"2013","journal-title":"Cancer Lett"},{"issue":"6","key":"2026051113453103500_ref46","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1002\/cncr.26423","article-title":"Modifying effect of MDM4 variants on risk of HPV16-associated squamous cell carcinoma of oropharynx","volume":"118","author":"Yu","year":"2012","journal-title":"Cancer"},{"issue":"6","key":"2026051113453103500_ref47","doi-asserted-by":"publisher","first-page":"820","DOI":"10.3390\/cancers11060820","article-title":"Prevalence of human papillomavirus (HPV) infection and the association with survival in Saudi patients with head and neck squamous cell carcinoma","volume":"11","author":"Alsbeih","year":"2019","journal-title":"Cancers"},{"issue":"1","key":"2026051113453103500_ref48","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40463-016-0168-9","article-title":"Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer","volume":"45","author":"Idris","year":"2016","journal-title":"J Otolaryngol Head Neck Surg"},{"issue":"3","key":"2026051113453103500_ref49","doi-asserted-by":"publisher","first-page":"301","DOI":"10.2217\/bmm.16.2","article-title":"Salivary epigenetic biomarkers in head and neck squamous cell carcinomas","volume":"10","author":"Lim","year":"2016","journal-title":"Biomark Med"},{"key":"2026051113453103500_ref50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.oraloncology.2017.03.004","article-title":"Risk factors for oropharynx cancer in a cohort of HIV-infected veterans","volume":"68","author":"Chew","year":"2017","journal-title":"Oral Oncol"},{"issue":"5","key":"2026051113453103500_ref51","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/hed.21793","article-title":"Trends in the incidence of oral cavity and oropharyngeal cancers in Spain","volume":"34","author":"De Souza","year":"2012","journal-title":"Head Neck"},{"issue":"5","key":"2026051113453103500_ref52","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.oraloncology.2014.01.016","article-title":"International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site","volume":"50","author":"Simard","year":"2014","journal-title":"Oral Oncol"},{"issue":"1","key":"2026051113453103500_ref53","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1186\/1471-2407-13-333","article-title":"Trends of lip, oral cavity and oropharyngeal cancers in Australia 1982\u20132008: overall good news but with rising rates in the oropharynx","volume":"13","author":"Ariyawardana","year":"2013","journal-title":"BMC Cancer"},{"issue":"1","key":"2026051113453103500_ref54","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.canep.2013.12.004","article-title":"Comparison of oropharyngeal and oral cavity squamous cell cancer incidence and trends in New Zealand and Queensland, AUstralia","volume":"38","author":"Elwood","year":"2014","journal-title":"Cancer Epidemiol"},{"issue":"4","key":"2026051113453103500_ref55","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s10552-014-0348-8","article-title":"Human papillomavirus (HPV) 16 and the prognosis of head and neck cancer in a geographical region with a low prevalence of HPV infection","volume":"25","author":"L\u00f3pez","year":"2014","journal-title":"Cancer Causes Control"},{"issue":"7","key":"2026051113453103500_ref56","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1002\/lary.26972","article-title":"Oropharyngeal squamous cell carcinoma incidence and mortality trends in the United States, 1973\u20132013","volume":"128","author":"Megwalu","year":"2018","journal-title":"Laryngoscope"},{"issue":"1","key":"2026051113453103500_ref57","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1875-595x.2012.00131.x","article-title":"Oral cancer in India continues in epidemic proportions: evidence base and policy initiatives","volume":"63","author":"Gupta","year":"2013","journal-title":"Int Dent J"},{"issue":"6","key":"2026051113453103500_ref58","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.mcna.2014.08.005","article-title":"Oral and oropharyngeal cancer","volume":"98","author":"Huber","year":"2014","journal-title":"Med Clin North Am"},{"issue":"10","key":"2026051113453103500_ref59","doi-asserted-by":"publisher","first-page":"5567","DOI":"10.7314\/APJCP.2013.14.10.5567","article-title":"Epidemiology of oral cancer in Asia in the past decade-an update (2000-2012)","volume":"14","author":"Rao","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"issue":"15","key":"2026051113453103500_ref60","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.7314\/APJCP.2014.15.15.5983","article-title":"Emerging and established global life-style risk factors for cancer of the upper aero-digestive tract","volume":"15","author":"Gupta","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"issue":"11","key":"2026051113453103500_ref61","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.11410","article-title":"Sexual behaviour and human papillomavirus-positive oral cavity and oropharyngeal cancer: an Irish perspective","volume":"12","author":"Crotty","year":"2020","journal-title":"Cureus"},{"key":"2026051113453103500_ref62","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ebiom.2020.103123","article-title":"Characterization of human papillomavirus (HPV) 16 E6 seropositive individuals without HPV-associated malignancies after 10 years of follow-up in the UK Biobank","author":"Brenner","year":"2020","journal-title":"EBioMedicine"},{"issue":"13","key":"2026051113453103500_ref63","doi-asserted-by":"publisher","first-page":"5525","DOI":"10.7314\/APJCP.2015.16.13.5525","article-title":"Saliva-based screening of high-risk human papillomavirus strains: detection in female Indonesian and Thai dental students","volume":"16","author":"Wimardhani","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"issue":"65","key":"2026051113453103500_ref64","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22682","article-title":"Detection of HPV related oropharyngeal cancer in oral rinse specimens","volume":"8","author":"Rosenthal","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"2026051113453103500_ref65","doi-asserted-by":"publisher","first-page":"203","DOI":"10.14219\/jada.archive.2006.0146","article-title":"Disparities in oral and pharyngeal cancer incidence, mortality and survival among black and white Americans","volume":"137","author":"Morse","year":"2006","journal-title":"J Am Dent Assoc"},{"issue":"9","key":"2026051113453103500_ref66","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1080\/00016480601110162","article-title":"Recurrence in patients with oral and oropharyngeal squamous cell carcinoma: human papillomavirus and other risk factors","volume":"127","author":"Rosenquist","year":"2007","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"2026051113453103500_ref67","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.oraloncology.2013.06.007","article-title":"Prospects for prevention of HPV-driven oropharynx cancer","volume":"50","author":"Kreimer","year":"2014","journal-title":"Oral Oncol"},{"issue":"1","key":"2026051113453103500_ref68","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/cancers14010033","article-title":"Vaccine strategies for human papillomavirus-associated head and neck cancers","volume":"14","author":"Zhou","year":"2021","journal-title":"Cancers"},{"issue":"12","key":"2026051113453103500_ref69","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.3390\/cancers13123010","article-title":"Sensitivity and specificity of human papillomavirus (HPV) 16 early antigen serology for HPV-driven oropharyngeal cancer: a systematic literature review and meta-analysis","volume":"13","author":"Hibbert","year":"2021","journal-title":"Cancers"},{"issue":"4","key":"2026051113453103500_ref70","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/dj10040054","article-title":"Assessment of oral human papillomavirus prevalence in pediatric and adult patients within a multi-ethnic clinic population","volume":"10","author":"Kornhaber","year":"2022","journal-title":"Dent J (Basel)"},{"issue":"4","key":"2026051113453103500_ref71","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s13187-019-01512-7","article-title":"Educational interventions on human papillomavirus for oral health providers","volume":"35","author":"Pampena","year":"2020","journal-title":"J Cancer Educ"},{"issue":"2","key":"2026051113453103500_ref72","doi-asserted-by":"publisher","first-page":"61","DOI":"10.5603\/NJO.2019.0009","article-title":"Awareness and health-enhancing behavior of oral cancer among high school students","volume":"4","author":"Wnuk","year":"2019","journal-title":"Nowotwory J Oncol"},{"issue":"2","key":"2026051113453103500_ref73","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4103\/ijocr.ijocr_17_24","article-title":"Analyzing the effects of HPV vaccination programs on the incidence of oral cancers and other related pathologies","volume":"12","author":"Singh","year":"2024","journal-title":"Int J Oral Care Res"},{"issue":"1","key":"2026051113453103500_ref74","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1922\/CDH_00072Kaczmarczyk08","article-title":"The impact of HPV vaccination on the prevention of oropharyngeal cancer: a scoping review","volume":"39","author":"Kaczmarczyk","year":"2022","journal-title":"Community Dent Health"},{"issue":"10","key":"2026051113453103500_ref75","doi-asserted-by":"publisher","first-page":"e212907-e","DOI":"10.1001\/jamaoncol.2021.2907","article-title":"Projected association of human papillomavirus vaccination with oropharynx cancer incidence in the US, 2020-2045","volume":"7","author":"Zhang","year":"2021","journal-title":"JAMA Oncol"},{"issue":"3","key":"2026051113453103500_ref76","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3390\/vaccines8030391","article-title":"Human papillomavirus vaccines: an updated review","volume":"8","author":"Cheng","year":"2020","journal-title":"Vaccines"},{"issue":"7","key":"2026051113453103500_ref77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068329","article-title":"Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica","volume":"8","author":"Herrero","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"2026051113453103500_ref78","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/jop.13091","article-title":"The impact of HPV vaccination on the prevalence of oropharyngeal cancer (OPC) in a hospital-based population: A cross-sectional study of patient\u2019s registry","volume":"50","author":"Katz","year":"2021","journal-title":"J Oral Pathol Med"},{"issue":"8","key":"2026051113453103500_ref79","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1093\/cid\/ciy1081","article-title":"Human papillomavirus (HPV) vaccine effectiveness and potential herd immunity for reducing oncogenic oropharyngeal HPV-16 prevalence in the United Kingdom: a cross-sectional study","volume":"69","author":"Mehanna","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"8","key":"2026051113453103500_ref80","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/infdis\/jiw359","article-title":"Quadrivalent human papillomavirus (HPV) vaccine induces HPV-specific antibodies in the oral cavity: results from the mid-adult male vaccine trial","volume":"214","author":"Pinto","year":"2016","journal-title":"J Infect Dis"},{"issue":"1","key":"2026051113453103500_ref81","doi-asserted-by":"publisher","first-page":"djv302","DOI":"10.1093\/jnci\/djv302","article-title":"Multisite HPV16\/18 vaccine efficacy against cervical, anal, and oral HPV infection","volume":"108","author":"Beachler","year":"2016","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"2026051113453103500_ref82","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.3390\/v13071339","article-title":"The effect of prophylactic HPV vaccines on oral and oropharyngeal HPV infection\u2014a systematic review","volume":"13","author":"Nielsen","year":"2021","journal-title":"Viruses"},{"issue":"6","key":"2026051113453103500_ref83","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1080\/21645515.2015.1095415","article-title":"Morbidity, mortality and cost from HPV-related oropharyngeal cancer: Impact of 2-, 4-and 9-valent vaccines","volume":"12","author":"Ward","year":"2016","journal-title":"Hum Vaccin Immunother"},{"issue":"1","key":"2026051113453103500_ref84","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/ijc.32791","article-title":"Effectiveness of the AS04-adjuvanted HPV-16\/18 vaccine in reducing oropharyngeal HPV infections in young females\u2014Results from a community-randomized trial","volume":"147","author":"Lehtinen","year":"2020","journal-title":"Int J Cancer"},{"issue":"15","key":"2026051113453103500_ref85","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1002\/cncr.29992","article-title":"The potential impact of prophylactic human papillomavirus vaccination on oropharyngeal cancer","volume":"122","author":"Guo","year":"2016","journal-title":"Cancer"},{"issue":"1","key":"2026051113453103500_ref86","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S1470-2045(11)70286-8","article-title":"Overall efficacy of HPV-16\/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial","volume":"13","author":"Lehtinen","year":"2012","journal-title":"Lancet Oncol"},{"issue":"3","key":"2026051113453103500_ref87","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1017\/S0950268815002198","article-title":"Prophylactic HPV vaccination: past, present, and future","volume":"144","author":"Castle","year":"2016","journal-title":"Epidemiol Infect"},{"issue":"2","key":"2026051113453103500_ref88","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/joim.13010","article-title":"A global epidemic increase of an HPV-induced tonsil and tongue base cancer\u2013potential benefit from a pan-gender use of HPV vaccine","volume":"287","author":"N\u00e4sman","year":"2020","journal-title":"J Intern Med"},{"issue":"10","key":"2026051113453103500_ref89","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/S1473-3099(20)30687-3","article-title":"Prevalence of human papillomavirus in young men who have sex with men after the implementation of gender-neutral HPV vaccination: a repeated cross-sectional study","volume":"21","author":"Chow","year":"2021","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"2026051113453103500_ref90","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/jnci\/djad009","article-title":"Upper age limits for US male human papillomavirus vaccination for oropharyngeal cancer prevention: a microsimulation-based modeling study","volume":"115","author":"Landy","year":"2023","journal-title":"J Nat Cancer Institute"},{"issue":"30","key":"2026051113453103500_ref91","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1016\/j.vaccine.2020.05.031","article-title":"Cost-effectiveness analysis of a gender-neutral human papillomavirus vaccination program in the Netherlands","volume":"38","author":"Simons","year":"2020","journal-title":"Vaccine"},{"key":"2026051113453103500_ref92","volume-title":"Making choices in health: WHO guide to cost-effectiveness analysis","author":"Tan-Torres Edejer","year":"2003"},{"issue":"4","key":"2026051113453103500_ref93","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1177\/0194599817695806","article-title":"A survey of Wisconsin pediatricians\u2019 knowledge and practices regarding the human papillomavirus vaccine","volume":"156","author":"Rohrbach","year":"2017","journal-title":"Otolaryngology\u2013Head and Neck Surgery"},{"issue":"2","key":"2026051113453103500_ref94","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014255","article-title":"Parents' views of including young boys in the Swedish national school-based HPV vaccination programme: a qualitative study","volume":"7","author":"Gottvall","year":"2017","journal-title":"BMJ Open"},{"issue":"4","key":"2026051113453103500_ref95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195801","article-title":"Attitudes towards and knowledge about Human Papillomavirus (HPV) and the HPV vaccination in parents of teenage boys in the UK","volume":"13","author":"Sherman","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"2026051113453103500_ref96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291990","article-title":"Global perspectives of determinants influencing HPV vaccine introduction and scale-up in low-and middle-income countries","volume":"19","author":"Guillaume","year":"2024","journal-title":"PLoS One"},{"issue":"21","key":"2026051113453103500_ref97","doi-asserted-by":"publisher","first-page":"6998","DOI":"10.3390\/ijerph20216998","article-title":"Understanding HPV vaccination policymaking in Rwanda: a case of health prioritization and public-private-partnership in a low-resource setting","volume":"20","author":"Asempah","year":"2023","journal-title":"Int J Environ Res Public Health"},{"key":"2026051113453103500_ref98","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ijgo.12186","article-title":"Progress in HPV vaccination in low-and lower-middle-income countries","volume":"138","author":"Lamontagne","year":"2017","journal-title":"Int J Gynecol Obstet"},{"key":"2026051113453103500_ref99","doi-asserted-by":"publisher","first-page":"1197191","DOI":"10.3389\/fimmu.2023.1197191","article-title":"Effectiveness and cost-effectiveness of human papillomavirus vaccination strategies among men who have sex with men in China: a modeling study","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"2026051113453103500_ref100","doi-asserted-by":"publisher","first-page":"91","DOI":"10.18632\/oncoscience.541","article-title":"Determining the utility of a screening program to reduce the incidence of HPV driven oropharyngeal cancer","volume":"8","author":"Vasani","year":"2021","journal-title":"Oncoscience"},{"issue":"1","key":"2026051113453103500_ref101","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40463-016-0177-8","article-title":"Ultrasensitive detection of oncogenic human papillomavirus in oropharyngeal tissue swabs","volume":"46","author":"Isaac","year":"2017","journal-title":"J Otolaryngol Head Neck Surg"},{"issue":"11","key":"2026051113453103500_ref102","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1002\/hed.26830","article-title":"Current salivary biomarkers for detection of human papilloma virus-induced oropharyngeal squamous cell carcinoma","volume":"43","author":"Smith","year":"2021","journal-title":"Head Neck"},{"issue":"12","key":"2026051113453103500_ref103","doi-asserted-by":"publisher","first-page":"2748","DOI":"10.1002\/ijc.30697","article-title":"Sensitivity and specificity of antibodies against HPV16 E6 and other early proteins for the detection of HPV16-driven oropharyngeal squamous cell carcinoma","volume":"140","author":"Holzinger","year":"2017","journal-title":"Int J Cancer"},{"key":"2026051113453103500_ref104","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3389\/fonc.2020.00408","article-title":"An occult HPV-driven oropharyngeal squamous cell carcinoma discovered through a saliva test","volume":"10","author":"Tang","year":"2020","journal-title":"Front Oncol"},{"issue":"10","key":"2026051113453103500_ref105","doi-asserted-by":"publisher","first-page":"3854","DOI":"10.1111\/cas.14585","article-title":"Oral HPV16 DNA as a screening tool to detect early oropharyngeal squamous cell carcinoma","volume":"111","author":"Tang","year":"2020","journal-title":"Cancer Sci"},{"key":"2026051113453103500_ref106","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6057","article-title":"Saliva-based detection of oral HPV and oral cancer","author":"Izumchenko","year":"2024","journal-title":"Am Soc Clin Oncol"},{"issue":"10","key":"2026051113453103500_ref107","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1158\/1940-6207.CAPR-19-0185","article-title":"Evaluating the utility and prevalence of HPV biomarkers in oral rinses and serology for HPV-related oropharyngeal cancer","volume":"12","author":"D'Souza","year":"2019","journal-title":"Cancer Prev Res"},{"key":"2026051113453103500_ref108","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6064","article-title":"Multi-feature next-generation liquid biopsy for diagnosis and prognosis in HPV-associated head and neck cancer","author":"Aye","year":"2024","journal-title":"Am Soc Clin Oncol"},{"issue":"11","key":"2026051113453103500_ref109","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1001\/jamaoto.2023.1937","article-title":"Performance of liquid biopsy for diagnosis and surveillance of human papillomavirus\u2013associated oropharyngeal cancer","volume":"149","author":"Ferrandino","year":"2023","journal-title":"JAMA Otolaryngol\u2013Head Neck Surg"},{"issue":"12","key":"2026051113453103500_ref110","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1002\/cncr.30588","article-title":"Human papillomavirus in cervical cancer and oropharyngeal cancer: one cause, two diseases","volume":"123","author":"Berman","year":"2017","journal-title":"Cancer"},{"issue":"9","key":"2026051113453103500_ref111","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1007\/s10552-010-9564-z","article-title":"Tobacco and alcohol use increases the risk of both HPV-associated and HPV-independent head and neck cancers","volume":"21","author":"Smith","year":"2010","journal-title":"Cancer Causes Control"},{"issue":"21","key":"2026051113453103500_ref112","doi-asserted-by":"publisher","first-page":"6510","DOI":"10.3390\/jcm11216510","article-title":"Impact of alcohol and smoking on outcomes of HPV-related oropharyngeal cancer","volume":"11","author":"Lai","year":"2022","journal-title":"J Clin Med"},{"issue":"5","key":"2026051113453103500_ref113","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/lio2.877","article-title":"Does human papillomavirus modify the risk of oropharyngeal cancer related to smoking and alcohol drinking? A systematic review and meta-analysis","volume":"7","author":"Arif","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"1","key":"2026051113453103500_ref114","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1186\/s12885-023-10948-6","article-title":"Joint effect of human papillomavirus exposure, smoking and alcohol on risk of oral squamous cell carcinoma","volume":"23","author":"Yang","year":"2023","journal-title":"BMC Cancer"},{"key":"2026051113453103500_ref115","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.926555","article-title":"Trends in oropharyngeal cancer incidence among adult men and women in the United States from 2001 to 2018","volume":"12","author":"Guo","year":"2022","journal-title":"Front Oncol"},{"issue":"7","key":"2026051113453103500_ref116","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1080\/14737140.2022.2088514","article-title":"Is 2045 the best we can do? Mitigating the HPV-related oropharyngeal cancer epidemic","volume":"22","author":"Schuman","year":"2022","journal-title":"Expert Rev Anticancer Ther"},{"key":"2026051113453103500_ref117","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2022.40.16_suppl.10534","article-title":"Factors associated with the decreasing rate of oropharyngeal cancer in young adults in the United States","author":"Chan","year":"2022","journal-title":"Am Soc Clin Oncol"},{"issue":"3","key":"2026051113453103500_ref118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151098","article-title":"Age effects and temporal trends in HPV-related and HPV-unrelated oral cancer in the United States: a multistage carcinogenesis modeling analysis","volume":"11","author":"Brouwer","year":"2016","journal-title":"PloS One"},{"issue":"9","key":"2026051113453103500_ref119","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1002\/hed.25810","article-title":"Projected oropharyngeal carcinoma incidence among middle-aged US men","volume":"41","author":"Xu","year":"2019","journal-title":"Head Neck"},{"issue":"1","key":"2026051113453103500_ref120","doi-asserted-by":"publisher","first-page":"21048","DOI":"10.1038\/s41598-025-06700-8","article-title":"HPV cancer burden by anatomical site, country, and region in 2022","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci Rep"}],"container-title":["Epidemiologic Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/epirev\/advance-article-pdf\/doi\/10.1093\/epirev\/mxag006\/67369715\/mxag006.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/epirev\/article-pdf\/48\/1\/mxag006\/67369715\/mxag006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/epirev\/article-pdf\/48\/1\/mxag006\/67369715\/mxag006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:45:37Z","timestamp":1778521537000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/epirev\/article\/doi\/10.1093\/epirev\/mxag006\/8524841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,29]]}},"URL":"https:\/\/doi.org\/10.1093\/epirev\/mxag006","relation":{},"ISSN":["1478-6729"],"issn-type":[{"value":"1478-6729","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"mxag006"}}